Index

Compounds

Compounds with at least one graded finding, ordered by how much has been read about them. Grade ranges span every finding on the page, not the best one.

Studied

16 compounds

16 compounds carry at least one graded finding, from 96 papers across 138 endpoints. 13 of them hold findings that disagree about how strong the evidence is, which is why the badge shows a range rather than a mark.

177 reported finding76 null result

curcuminCompoundCHEBI:3962A β-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.Grade B, Likely. Human evidence, limited replication or design limits.39 findings26 endpoints13 papers
B to C across 39 findings
melatoninCompoundCHEBI:16796A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.Grade A, Well established. Replicated human trial evidence, consistent direction.29 findings19 endpoints13 papers
A to C across 29 findings
creatineCompoundCHEBI:16919Nitrogenous organic acid; substrate of the creatine kinase phosphagen system. Supplement forms are recorded on the edge, not as separate nodes.Grade A, Well established. Replicated human trial evidence, consistent direction.13 findings10 endpoints10 papers
A to C across 13 findings
resveratrolCompoundCHEBI:27881A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.Grade A, Well established. Replicated human trial evidence, consistent direction.13 findings13 endpoints8 papers
A to F across 13 findings
coenzyme Q10CompoundCHEBI:46245Pinned: ChEBI labels the entry by its common name, so the systematic form missed. Ubiquinol is the reduced form and a separate node if a trial doses it — products sell both and they are not interchangeable.Grade A, Well established. Replicated human trial evidence, consistent direction.13 findings12 endpoints4 papers
A to C across 13 findings
nitrateCompoundCHEBI:17632A nitrogen oxoanion formed by loss of a proton from nitric acid. Principal species present at pH 7.3.Grade B, Likely. Human evidence, limited replication or design limits.12 findings9 endpoints8 papers
B to D across 12 findings
magnesium(2+)ElementCHEBI:18420The cation, and a DELIBERATE divergence from the phosphocreatine precedent that chose a neutral parent. Neutral phosphocreatine is a real species in equilibrium with its anion; a neutral magnesium ATOM (CHEBI:25107) is elemental metal, which nobody ingests and which no trial doses. The entity present in every salt and in plasma is Mg(2+). Glycinate, citrate and oxide are FORMS in dose_regimen — bioavailability differs sharply between them, which is why the form must be on every edge.Grade B, Likely. Human evidence, limited replication or design limits.11 findings10 endpoints7 papers
B to D across 11 findings
L-glutamineCompoundCHEBI:18050An optically active form of glutamine having L-configuration.Grade A, Well established. Replicated human trial evidence, consistent direction.10 findings7 endpoints8 papers
A to B across 10 findings
caffeineCompoundCHEBI:27732A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.Grade B, Likely. Human evidence, limited replication or design limits.10 findings8 endpoints7 papers
B to C across 10 findings
methylene blueCompoundCHEBI:6872An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.Grade A, Well established. Replicated human trial evidence, consistent direction.5 findings4 endpoints3 papers
A to B across 5 findings
L-arginineCompoundCHEBI:16467An L-α-amino acid that is the L-isomer of arginine.Grade B, Likely. Human evidence, limited replication or design limits.5 findings5 endpoints4 papers
berberineCompoundCHEBI:16118Grade B, Likely. Human evidence, limited replication or design limits.5 findings5 endpoints4 papers
B to D across 5 findings

Show the remaining 4

Where compounds go

228 compounds

No paper has been read for these, so none carries a finding or a grade. What is known is where they go: 27 reach a single region and 8 are ubiquitous carriers that reach nearly everywhere, which is a fact about the carrier rather than about the compound.

Show the remaining 216

2,716 further compounds are resolved in the graph with neither a graded finding nor a known route, largely metabolic intermediates carried in from the reference sources. Their pages exist and state their own absence.