Compound
prostaglandin D2
The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C20H31O5
- Mass
- 351.463 g/mol
- Charge
- -1
- InChIKey
- BHMBVRSPMRCCGG-OUTUXVNYSA-M
- SMILES
- CCCCC[C@H](O)/C=C/[C@H]1C(=O)C[C@H](O)[C@@H]1C/C=CCCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only105 paths35 endpoints
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only56 paths13 endpoints
- PTGDSProteinUNIPROT:P41222substrate ofInferred only23 paths23 endpoints
- CBR1ProteinUNIPROT:P16152substrate ofInferred only22 paths22 endpoints
- AKR1C2ProteinUNIPROT:P52895substrate ofInferred only16 paths16 endpoints
- HPGDSProteinUNIPROT:O60760substrate ofInferred only11 paths11 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only9 paths2 endpoints
- SLCO2B1ProteinUNIPROT:O94956transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
32 statements
32 statements · 2 reference databases · Subject: prostaglandin D2 · Sources: Human-GEM, Rhea
- prostaglandin D2 is converted to 11beta-prostaglandin F2CompoundRhea RHEA:45316Inferred only
- prostaglandin D2 is converted to 15-oxoprostaglandin D2CompoundRhea RHEA:20744Inferred only
- prostaglandin D2 is converted to 15-oxoprostaglandin D2CompoundHuman-GEM MAR01336Inferred only
- 15-oxoprostaglandin D2 is converted to prostaglandin D2CompoundHuman-GEM MAR01336Inferred only
- prostaglandin D2 is converted to prostaglandin F2alphaCompoundHuman-GEM MAR01329Inferred only
- prostaglandin F2alpha is converted to prostaglandin D2CompoundHuman-GEM MAR01329Inferred only
- prostaglandin D2 is converted to prostaglandin F2alphaCompoundRhea RHEA:10140Inferred only
- prostaglandin H2 is converted to prostaglandin D2CompoundHuman-GEM MAR01330Inferred only
- prostaglandin H2 is converted to prostaglandin D2CompoundHuman-GEM MAR08559Inferred only
- prostaglandin H2 is converted to prostaglandin D2CompoundRhea RHEA:10600Inferred only
- prostaglandin D2 is converted to prostaglandin H2CompoundHuman-GEM MAR08559Inferred only
- prostaglandin J2 is converted to prostaglandin D2CompoundRhea RHEA:50556Inferred only
Show the remaining 20
- prostaglandin D2 is converted to prostaglandin J2CompoundHuman-GEM MAR01333Inferred only
- prostaglandin D2 is converted to prostaglandin J2CompoundRhea RHEA:50556Inferred only
- prostaglandin D2 is converted to prostaglandin J2CompoundHuman-GEM MAR01332Inferred only
- prostaglandin J2 is converted to prostaglandin D2CompoundHuman-GEM MAR01332Inferred only
- prostaglandin J2 is converted to prostaglandin D2CompoundHuman-GEM MAR01333Inferred only
- prostaglandin D2 is a substrate of AKR1C2ProteinRhea RHEA:45316Inferred only
- prostaglandin D2 is a substrate of AKR1C3ProteinHuman-GEM MAR01329Inferred only
- prostaglandin D2 is a substrate of AKR1C3ProteinRhea RHEA:10140Inferred only
- prostaglandin D2 is a substrate of AKR1C3ProteinRhea RHEA:45316Inferred only
- prostaglandin D2 is a substrate of CBR1ProteinRhea RHEA:20744Inferred only
- prostaglandin D2 is a substrate of HPGDSProteinHuman-GEM MAR08559Inferred only
- prostaglandin D2 is a substrate of PTGDSProteinHuman-GEM MAR08559Inferred only
- prostaglandin D2 is transported by SLCO1B1ProteinHuman-GEM MAR06185Inferred only
- prostaglandin D2 is transported by SLCO1B1ProteinHuman-GEM MAR06184Inferred only
- prostaglandin D2 is transported by SLCO1B1ProteinHuman-GEM MAR06186Inferred only
- prostaglandin D2 is transported by SLCO2A1ProteinHuman-GEM MAR08932Inferred only
- prostaglandin D2 is transported by SLCO2A1ProteinRhea RHEA:74403Inferred only
- prostaglandin D2 is transported by SLCO2A1ProteinHuman-GEM MAR06231Inferred only
- prostaglandin D2 is transported by SLCO2A1ProteinHuman-GEM MAR06266Inferred only
- prostaglandin D2 is transported by SLCO2B1ProteinRhea RHEA:50976Inferred only
Reactions
27 reactions
proton+NADPH(4-)+prostaglandin D2NADP(3-)+prostaglandin F2alpha
Catalysed by AKR1C3
Reaction pageReversibleBalancedEC 1.1.1.188cytosol
Human-GEM MAR01329CC BY 4.0Reference data
prostaglandin H2prostaglandin D2
Reaction pageLeft to rightBalancedEC 5.3.99.2cytosol
Human-GEM MAR01330CC BY 4.0Reference data
prostaglandin D2prostaglandin D2
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR01331CC BY 4.0Reference data
water+prostaglandin J2prostaglandin D2
Reaction pageReversibleBalancedcytosol
Human-GEM MAR01332CC BY 4.0Reference data
water+prostaglandin J2prostaglandin D2
Reaction pageReversibleBalancedendoplasmic reticulum
Human-GEM MAR01333CC BY 4.0Reference data
MAM00384c+waterprostaglandin D2
Reaction pageReversibleBalancedcytosol
Human-GEM MAR01334CC BY 4.0Reference data
MAM01662r+waterprostaglandin D2
Reaction pageReversibleBalancedendoplasmic reticulum
Human-GEM MAR01335CC BY 4.0Reference data
15-oxoprostaglandin D2+proton+NADPH(4-)NADP(3-)+prostaglandin D2
Reaction pageReversibleBalancedcytosol
Human-GEM MAR01336CC BY 4.0Reference data
MAM00382c+waterprostaglandin D2
Reaction pageReversibleBalancedcytosol
Human-GEM MAR01338CC BY 4.0Reference data
MAM01234c+water2proton+prostaglandin D2
Reaction pageReversibleUnbalancedcytosol
Human-GEM MAR01383CC BY 4.0Reference data
2proton+prostaglandin D2MAM01234r+water
Reaction pageReversibleUnbalancedEC 1.13.11.34endoplasmic reticulum
Human-GEM MAR03962CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin D2MAM01980e+hydrogencarbonate+prostaglandin D2
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR06184CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 15 tissues, 17 transporter routes — routes, not measurements: transporters known to carry prostaglandin D2 are expressed there, and no source reports it arriving.
Loading the model…
Other names
4 names
Resolves to: prostaglandin D2
- Also called
- PGD2prostaglandin D2 anion
- Systematic name
- (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dien-1-oate(5Z,13E,15S)-9α,15-dihydroxy-11-oxoprosta-5,13-dien-1-oate