Boron

Formula: H₃BO₃
Molar mass: 61.833 g/mol
ChEBI: CHEBI:33118
InChIKey: KGBXLFKZBHKPEV-UHFFFAOYSA-N

5findings
4endpoints
5papers
1no difference

↓ lowered 4 findings in 4 endpoints · – no difference found 1 in 1

01 · the evidence, ordered

What the evidence says

: Strong; 0
: Moderate; 0
: Limited; 1
: Very limited; 3
: Insufficient; 1

How to read these marks

Fig. 2 Boron CHEBI:33118 4 endpoints 5 findings

×1.60

Labels

CompoundInspector

Boron

Most findings

Prostate cancer incidence×2
All-cause mortality×1
Bleeding on probing×1
Lung cancer incidence×1

36 compounds on the outer ring, not drawn

Keys

← → round a ring↑ ↓ out and inEnter selecte the outer ringf fit to view+ − zoomEsc clearclick a node to select it

All-cause mortality
Prostate cancer incidencecontested
Bleeding on probing
Lung cancer incidence

fig. 3 · 4 endpoints · 5 findingscontested · an endpoint whose findings disagree

02 · contested · 1 endpoint

Where the findings disagree

012 findings
Prostate cancer incidence
↓ lowered
1
– no difference found
1

03 · findings

What boron moved, and by how much

Dose studied: as its paper gave it.
Evidence strength: computed from the study. How it is computed
Industry funding: named on its row.

Direction

Strength, at least

5 shown

All-cause mortalityMoved: lowersEvidence: LimitedPaper: PMID 346776812022Industry funded
Who
693 stable kidney transplant recipients (mean age 53), TransplantLines cohort; tertiles 2 and 3 of 24 h urinary boron excretion versus tertile 1, crude (unadjusted) hazard ratios
Dose studied
not reported
Patients in tertiles 2 and 3 of boron excretion had lower risk of mortality (HR: 0.59, 95% CI: 0.41 to 0.86, and HR: 0.36, 95% CI: 0.24 to 0.56, respectively) compared with patients in tertile 1 (Table 3).”
Quoted verbatim from Boron Intake and decreased risk of mortality in kidney transplant recipients.cohortPermalink
Lung cancer incidenceMoved: lowersEvidence: Very limitedPaper: PMID 183438802008
Who
Women in a Houston, Texas case-control study, 763 with lung cancer and 838 matched healthy controls; dietary boron intake by quartile
Dose studied
not reported
Boron intake was inversely associated with lung cancer in women, whereas women who consumed low boron and did not use HRT were at substantial increased odds.”
Quoted verbatim from Dietary boron and hormone replacement therapy as risk factors for lung cancer in women.case-controlPermalink
Bleeding on probingMoved: lowersEvidence: Very limitedPaper: PMID 231214602013
Who
45 systemically healthy adults with chronic periodontitis, scaling and root planing in all three arms plus 0.75% boric acid irrigation, chlorhexidine irrigation or saline irrigation; whole-mouth value at 1 month only · n = 45
Dose studied
0.75% boric acid subgingival irrigation
BOP (percentage) was significantly lower in the B group compared with the CHX and C groups in the first month after treatment (P <0.001).”
Quoted verbatim from Boric acid irrigation as an adjunct to mechanical periodontal therapy in patients with chronic periodontitis: a randomized clinical trial.RCT · 4 weeksPermalink
Prostate cancer incidencecontestedMoved: no difference foundEvidence: Very limitedPaper: PMID 178517702007
Who
Men in the VITAL cohort who completed the baseline supplement and food frequency questionnaire
Dose studied
not reported
Dietary boron intake and total boron intake from diet plus multivitamins were not associated with prostate cancer risk.”
Quoted verbatim from Boron intake and prostate cancer risk.cohortPermalink
Prostate cancer incidencecontestedMoved: lowersEvidence: InsufficientPaper: PMID 150108902004
Who
US men in NHANES III, 95 prostate cancer cases and 8,720 male controls, cross-sectional case-control design
Dose studied
not reported
After controlling for age, race, education, smoking, body mass index, dietary caloric intake, and alcohol consumption, increased dietary boron intake was associated with a decreased risk of prostate cancer with a dose-response pattern.”
Quoted verbatim from Dietary boron intake and prostate cancer risk.case-controlPermalink

No dose is advised.

Dose studied: as its paper gave it.
Evidence strength: computed from the study. How it is computed
Industry funding: named on its row.

04 · identity

Structure

fig. 4Boron · 2D structure · ChEBI’s SMILES

Charge: 0
SMILES: [H]OB(O[H])O[H]

05 · on the label · 4,044 products

Labelled products

Source: NIH DSLD · Ingredient: boric acid · 4,044 products · Declared amount per serving (the first 1,000 shown): 0–222 mg

915 labels of the first 1,000 shown state an amount85 do not

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21st Century600+D3 plus Minerals Fruit PunchBoron, as Sodium Borate250 µgper 1 tabletDSLD:206824
21st CenturyArthri-Flex Advantage + Vitamin D3amount not statedper 2 tabletsDSLD:207404
21st CenturyCalcium PlusBoron, as Sodium Borate500 µgper 2 capletsDSLD:11140
21st CenturyDiabetic Support FormulaBoron, as Borates150 µgper 3 tabletsDSLD:11189
21st CenturyEstro Support ESBoron, as Boron Amino Acid Chelate1.5 mgper 1 tabletDSLD:207388
21st CenturyGlucosamine Chondroitin Complex plus MSM Advanced Triple StrengthBoron, as Sodium Borate3 mgper 2 tabletsDSLD:206833
21st CenturyOne Daily ActiveBoron, as Borates150 µgper 1 tabletDSLD:11548
21st CenturyOne Daily Cholesterol Health With PolicosanolBoron, as Sodium Borate150 µgper 1 tabletDSLD:11550
21st CenturyOne Daily EnergyBoron, as Sodium Borate150 µgper 1 tabletDSLD:11552
21st CenturyOne Daily MaximumBoron, as Borates150 µgper 1 tabletDSLD:11558
21st CenturySentry AdultsBoron, as Sodium Borate75 µgper 1 tabletDSLD:207458
21st CenturySentry EnergyBoron, as Borate60 µgper 1 tabletDSLD:207442