Endpoint
Sequential Organ Failure Assessment (SOFA) total score
CAT:outcome/sofa-total-scorereported in points1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-citrulline | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Every finding here is a null result.
Measured, no effect detected
1 finding
L-citrulline — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Overall, there was no significant difference in organ dysfunction as assessed by the SOFA score on day 7 after enrollment (4 [IQR, 2-6] in the L-citrulline group vs. 4 [IQR, 2-7] in the placebo group; Mann‒Whitney U test, p = 0.9).”
Quoted verbatim from Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial.. - Study
- RCT
- Dose
- 5 g enteral L-citrulline every 12 h for 5 days versus isonitrogenous, isocaloric placebo
- Population
- Mechanically ventilated medical ICU adults without sepsis or septic shock, four French ICUs
Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial.2023PMID:37784110Permalink
How it is measured
Total score on the Sequential Organ Failure Assessment, summing six organ-system subscores (respiration, coagulation, liver, cardiovascular, central nervous system, renal) each rated 0 to 4, giving a total of 0 to 24, in critically ill patients. The study day on which it was scored, and how missing values after death or ICU discharge were handled, are recorded with each finding.
Sources cited
1 paper
- Subject
- sequential organ failure assessment (sofa) total score
- Findings
- 1
- Papers
- 1