Compound
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
The pentaanion of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Definition from ChEBI (CHEBI:58456), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Structural class, not a single molecule
- Formula
- C11H14O19P3R2
- Mass
- 543.139 g/mol
- Charge
- -5
- SMILES
- *C(=O)OC[C@]([H])(COP(=O)([O-])O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)([O-])[O-])[C@H]1O)OC(*)=O
- Look it up
- ChEBI
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
31 entities
31 entities reached.
0 reported hops31 assembled from the scaffold
- PIK3CAProteinUNIPROT:P42336substrate ofInferred only259 paths259 endpoints
- PLCG1ProteinUNIPROT:P19174substrate ofInferred only220 paths220 endpoints
- PIK3CDProteinUNIPROT:O00329substrate ofInferred only110 paths110 endpoints
- PIK3CBProteinUNIPROT:P42338substrate ofInferred only86 paths86 endpoints
- PIK3CGProteinUNIPROT:P48736substrate ofInferred only84 paths84 endpoints
- PLCG2ProteinUNIPROT:P16885substrate ofInferred only63 paths63 endpoints
- PLCB3ProteinUNIPROT:Q01970substrate ofInferred only58 paths58 endpoints
- PLCB1ProteinUNIPROT:Q9NQ66substrate ofInferred only56 paths56 endpoints
- PLCB2ProteinUNIPROT:Q00722substrate ofInferred only56 paths56 endpoints
- INPP5DProteinUNIPROT:Q92835substrate ofInferred only38 paths38 endpoints
- PLCB4ProteinUNIPROT:Q15147substrate ofInferred only31 paths31 endpoints
- PIK3C2AProteinUNIPROT:O00443substrate ofInferred only30 paths30 endpoints
Show the remaining 19
- OCRLProteinUNIPROT:Q01968substrate ofInferred only28 paths28 endpoints
- SYNJ1ProteinUNIPROT:O43426substrate ofInferred only21 paths21 endpoints
- PLCD1ProteinUNIPROT:P51178substrate ofInferred only17 paths17 endpoints
- PIP4P1ProteinUNIPROT:Q86T03substrate ofInferred only12 paths12 endpoints
- PLCE1ProteinUNIPROT:Q9P212substrate ofInferred only12 paths12 endpoints
- SYNJ2ProteinUNIPROT:O15056substrate ofInferred only11 paths11 endpoints
- INPP5EProteinUNIPROT:Q9NRR6substrate ofInferred only10 paths10 endpoints
- INPP5JProteinUNIPROT:Q15735substrate ofInferred only8 paths8 endpoints
- FIG4ProteinUNIPROT:Q92562substrate ofInferred only8 paths8 endpoints
- PLCD4ProteinUNIPROT:Q9BRC7substrate ofInferred only8 paths8 endpoints
- PLCH1ProteinUNIPROT:Q4KWH8substrate ofInferred only7 paths7 endpoints
- PLCD3ProteinUNIPROT:Q8N3E9substrate ofInferred only7 paths7 endpoints
- INPP5KProteinUNIPROT:Q9BT40substrate ofInferred only7 paths7 endpoints
- PLCZ1ProteinUNIPROT:Q86YW0substrate ofInferred only6 paths6 endpoints
- OSBPL2ProteinUNIPROT:Q9H1P3transported byInferred only6 paths6 endpoints
- INPP5BProteinUNIPROT:P32019substrate ofInferred only6 paths6 endpoints
- PLCH2ProteinUNIPROT:O75038substrate ofInferred only5 paths5 endpoints
- IPMKProteinUNIPROT:Q8NFU5substrate ofInferred only3 paths3 endpoints
- OSBP2ProteinUNIPROT:Q969R2transported byInferred only1 path1 endpoint
What the reference databases state
Statements
37 statements
37 statements · 1 reference database · Subject: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) · Sources: Rhea
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is converted to a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)CompoundRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) is converted to a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)CompoundRhea RHEA:14425Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) is converted to a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)CompoundRhea RHEA:25674Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is converted to a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)CompoundRhea RHEA:25674Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) is converted to a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)CompoundRhea RHEA:12280Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of FIG4ProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of INPP5BProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of INPP5DProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of INPP5EProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of INPP5JProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of INPP5KProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of IPMKProteinRhea RHEA:21292Inferred only
Show the remaining 25
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of OCRLProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PIK3C2AProteinRhea RHEA:21292Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PIK3CAProteinRhea RHEA:21292Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PIK3CBProteinRhea RHEA:21292Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PIK3CDProteinRhea RHEA:21292Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PIK3CGProteinRhea RHEA:21292Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PIP4P1ProteinRhea RHEA:25674Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PIP4P2ProteinRhea RHEA:25674Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCB1ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCB2ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCB3ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCB4ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCD1ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCD3ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCD4ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCE1ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCG1ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCG2ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCH1ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCH2ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of PLCZ1ProteinRhea RHEA:33179Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of SYNJ1ProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is a substrate of SYNJ2ProteinRhea RHEA:22764Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is transported by OSBP2ProteinRhea RHEA:84879Inferred only
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) is transported by OSBPL2ProteinRhea RHEA:84879Inferred only
Reactions
9 reactions
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATP(4-)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+ADP(3-)+hydron
Catalysed by PIP4K2A or PIP4K2B or PIP4K2C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12280CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ATP(4-)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+ADP(3-)+hydron
Catalysed by PIP5K1B or PIP5K1C or PIP5K1A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:14425CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+ATP(4-)CHEBI:57836+ADP(3-)+hydron
Catalysed by PIK3CD or PIK3C2A or PIK3CA or PIK3CB or PIK3CG or IPMK
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21292CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5J or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22764CC BY 4.0Reference data
CHEBI:57836+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+hydrogenphosphate
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:25017CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+hydrogenphosphate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:25674CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+water1D-myo-inositol 1,4,5-trisphosphate+a 1,2-diacyl-sn-glycerol+hydron
Catalysed by PLCH2 or PLCG2 or PLCG1 or PLCD1 or PLCB2 or PLCB3 or PLCB4 or PLCH1 or PLCZ1 or PLCD3 or PLCD4 or PLCB1 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33179CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+cholesterola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+cholesterol
Transported by OSBP2 or OSBPL2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:84879CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:85915CC BY 4.0Reference data
Where it reaches
4 systems, 4 regions, 7 tissues, 7 transporter routes — routes, not measurements: transporters known to carry a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
- Also called
- 1,2-diacyl-sn-glycero-3-phospho-1D-myo-inositol-4,5-bisphosphatePIP2[4,5]
- Systematic name
- 2,3-bis(alkanoyloxy)propyl (1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonatooxy)cyclohexyl phosphate