Compound
L-asparagine
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from aspartic acid and ammonia by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C4H8N2O3
- Mass
- 132.119 g/mol
- Charge
- 0
- InChIKey
- DCXYFEDJOCDNAF-REOHCLBHSA-N
- SMILES
- NC(=O)C[C@H]([NH3+])C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
28 entities
28 entities reached.
0 reported hops28 assembled from the scaffold
- SLC38A2ProteinUNIPROT:Q96QD8transported byInferred only594 paths198 endpoints
- SLC1A5ProteinUNIPROT:Q15758transported byInferred only540 paths44 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only129 paths8 endpoints
- SLC38A1ProteinUNIPROT:Q9H2H9transported byInferred only114 paths38 endpoints
- SLC1A4ProteinUNIPROT:P43007transported byInferred only87 paths29 endpoints
- SLC7A9ProteinUNIPROT:P82251transported byInferred only45 paths9 endpoints
- SLC38A5ProteinUNIPROT:Q8WUX1transported byInferred only42 paths14 endpoints
- SLC7A6ProteinUNIPROT:Q92536transported byInferred only34 paths2 endpoints
- SLC43A1ProteinUNIPROT:O75387transported byInferred only33 paths33 endpoints
- ASNSProteinUNIPROT:P08243substrate ofInferred only29 paths29 endpoints
- NARS1ProteinUNIPROT:O43776substrate ofInferred only22 paths11 endpoints
- SLC7A8ProteinUNIPROT:Q9UHI5transported byInferred only18 paths18 endpoints
Show the remaining 16
- SLC7A7ProteinUNIPROT:Q9UM01transported byInferred only16 paths16 endpoints
- ASRGL1ProteinUNIPROT:Q7L266substrate ofInferred only12 paths4 endpoints
- SLC3A2ProteinUNIPROT:P08195transported byInferred only12 paths12 endpoints
- NAGSProteinUNIPROT:Q8N159substrate ofInferred only11 paths11 endpoints
- ASPGProteinUNIPROT:Q86U10substrate ofInferred only9 paths3 endpoints
- SLC38A4ProteinUNIPROT:Q969I6transported byInferred only6 paths2 endpoints
- SLC3A1ProteinUNIPROT:Q07837transported byInferred only5 paths1 endpoint
- NARS2ProteinUNIPROT:Q96I59substrate ofInferred only5 paths5 endpoints
- SLC36A1ProteinUNIPROT:Q7Z2H8transported byInferred only4 paths2 endpoints
- SLC6A14ProteinUNIPROT:Q9UN76transported byInferred only4 paths2 endpoints
- ASPAProteinUNIPROT:P45381substrate ofInferred only4 paths4 endpoints
- ACY3ProteinUNIPROT:Q96HD9substrate ofInferred only3 paths3 endpoints
- SLC38A3ProteinUNIPROT:Q99624transported byInferred only2 paths1 endpoint
- SLC6A15ProteinUNIPROT:Q9H2J7transported byInferred only2 paths1 endpoint
- SLC38A9ProteinUNIPROT:Q8NBW4transported byInferred only1 path1 endpoint
- CLTRNProteinUNIPROT:Q9HBJ8transported byInferred only1 path1 endpoint
What the reference databases state
Statements
111 statements
111 statements · 2 reference databases · Subject: L-asparagine · Sources: Human-GEM, Rhea
- 2-oxosuccinamate is converted to L-asparagineCompoundRhea RHEA:61224Inferred only
- L-asparagine is converted to 2-oxosuccinamateCompoundRhea RHEA:61224Inferred only
- L-asparagine is converted to 2-oxosuccinamateCompoundRhea RHEA:52528Inferred only
- 2-oxosuccinamate is converted to L-asparagineCompoundRhea RHEA:52528Inferred only
- L-asparagine is converted to L-aspartateCompoundHuman-GEM MAR03862Inferred only
- L-asparagine is converted to L-aspartateCompoundRhea RHEA:11372Inferred only
- L-asparagine is converted to L-aspartateCompoundRhea RHEA:21016Inferred only
- L-aspartate is converted to L-asparagineCompoundRhea RHEA:11372Inferred only
- L-asparagine is converted to L-aspartateCompoundHuman-GEM MAR04172Inferred only
- L-asparagine is converted to L-aspartateCompoundRhea RHEA:14197Inferred only
- L-aspartate is converted to L-asparagineCompoundRhea RHEA:14197Inferred only
- L-asparagine is a substrate of ACY3ProteinHuman-GEM MAR06969Inferred only
Show the remaining 99
- L-asparagine is a substrate of ASNSProteinRhea RHEA:12228Inferred only
- L-asparagine is a substrate of ASPAProteinHuman-GEM MAR06969Inferred only
- L-asparagine is a substrate of ASPGProteinRhea RHEA:21016Inferred only
- L-asparagine is a substrate of ASPGProteinHuman-GEM MAR03862Inferred only
- L-asparagine is a substrate of ASPGProteinHuman-GEM MAR04172Inferred only
- L-asparagine is a substrate of ASRGL1ProteinHuman-GEM MAR03862Inferred only
- L-asparagine is a substrate of ASRGL1ProteinHuman-GEM MAR04172Inferred only
- L-asparagine is a substrate of ASRGL1ProteinRhea RHEA:21016Inferred only
- L-asparagine is a substrate of NAGSProteinHuman-GEM MAR06968Inferred only
- L-asparagine is a substrate of NARS1ProteinHuman-GEM MAR05133Inferred only
- L-asparagine is a substrate of NARS1ProteinRhea RHEA:11180Inferred only
- L-asparagine is a substrate of NARS2ProteinRhea RHEA:11180Inferred only
- L-asparagine is transported by CLTRNProteinHuman-GEM MAR09872Inferred only
- L-asparagine is transported by SLC1A4ProteinRhea RHEA:84367Inferred only
- L-asparagine is transported by SLC1A4ProteinRhea RHEA:84355Inferred only
- L-asparagine is transported by SLC1A4ProteinHuman-GEM MAR05717Inferred only
- L-asparagine is transported by SLC1A5ProteinRhea RHEA:70891Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05612Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05627Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05642Inferred only
- L-asparagine is transported by SLC1A5ProteinRhea RHEA:70859Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05793Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05764Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05760Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05755Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05754Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05753Inferred only
- L-asparagine is transported by SLC1A5ProteinHuman-GEM MAR05717Inferred only
- L-asparagine is transported by SLC36A1ProteinHuman-GEM MAR05049Inferred only
- L-asparagine is transported by SLC36A1ProteinHuman-GEM MAR05088Inferred only
- L-asparagine is transported by SLC38A1ProteinRhea RHEA:71383Inferred only
- L-asparagine is transported by SLC38A1ProteinHuman-GEM MAR06382Inferred only
- L-asparagine is transported by SLC38A1ProteinHuman-GEM MAR05311Inferred only
- L-asparagine is transported by SLC38A2ProteinRhea RHEA:71383Inferred only
- L-asparagine is transported by SLC38A2ProteinHuman-GEM MAR05311Inferred only
- L-asparagine is transported by SLC38A2ProteinHuman-GEM MAR06382Inferred only
- L-asparagine is transported by SLC38A3ProteinHuman-GEM MAR05313Inferred only
- L-asparagine is transported by SLC38A3ProteinRhea RHEA:71131Inferred only
- L-asparagine is transported by SLC38A4ProteinHuman-GEM MAR05311Inferred only
- L-asparagine is transported by SLC38A4ProteinRhea RHEA:71383Inferred only
- L-asparagine is transported by SLC38A4ProteinHuman-GEM MAR06382Inferred only
- L-asparagine is transported by SLC38A5ProteinHuman-GEM MAR06382Inferred only
- L-asparagine is transported by SLC38A5ProteinHuman-GEM MAR05313Inferred only
- L-asparagine is transported by SLC38A5ProteinRhea RHEA:71131Inferred only
- L-asparagine is transported by SLC38A7ProteinRhea RHEA:71383Inferred only
- L-asparagine is transported by SLC38A9ProteinRhea RHEA:73423Inferred only
- L-asparagine is transported by SLC3A1ProteinHuman-GEM MAR05934Inferred only
- L-asparagine is transported by SLC3A1ProteinHuman-GEM MAR05950Inferred only
- L-asparagine is transported by SLC3A1ProteinHuman-GEM MAR05966Inferred only
- L-asparagine is transported by SLC3A1ProteinHuman-GEM MAR05982Inferred only
- L-asparagine is transported by SLC3A1ProteinHuman-GEM MAR05918Inferred only
- L-asparagine is transported by SLC3A2ProteinHuman-GEM MAR05088Inferred only
- L-asparagine is transported by SLC43A1ProteinHuman-GEM MAR05088Inferred only
- L-asparagine is transported by SLC6A14ProteinRhea RHEA:71323Inferred only
- L-asparagine is transported by SLC6A14ProteinHuman-GEM MAR06865Inferred only
- L-asparagine is transported by SLC6A15ProteinHuman-GEM MAR05311Inferred only
- L-asparagine is transported by SLC6A15ProteinRhea RHEA:71383Inferred only
- L-asparagine is transported by SLC6A18ProteinHuman-GEM MAR09872Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05545Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05537Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05528Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05518Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05507Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05495Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05482Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05552Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05088Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05672Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05657Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05571Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05570Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05569Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05568Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05563Inferred only
- L-asparagine is transported by SLC7A5ProteinHuman-GEM MAR05558Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05882Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05657Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05687Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05702Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05732Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05752Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05755Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05764Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05823Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05883Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05884Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05885Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05918Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05934Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05950Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05966Inferred only
- L-asparagine is transported by SLC7A6ProteinHuman-GEM MAR05982Inferred only
- L-asparagine is transported by SLC7A7ProteinHuman-GEM MAR05088Inferred only
- L-asparagine is transported by SLC7A8ProteinHuman-GEM MAR05088Inferred only
- L-asparagine is transported by SLC7A9ProteinHuman-GEM MAR05950Inferred only
- L-asparagine is transported by SLC7A9ProteinHuman-GEM MAR05982Inferred only
- L-asparagine is transported by SLC7A9ProteinHuman-GEM MAR05934Inferred only
- L-asparagine is transported by SLC7A9ProteinHuman-GEM MAR05966Inferred only
- L-asparagine is transported by SLC7A9ProteinHuman-GEM MAR05918Inferred only
Reactions
158 reactions
L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
L-asparagine+waterL-aspartate+proton+ammonium
Reaction pageLeft to rightBalancedEC 3.4.19.5mitochondrial matrix
Human-GEM MAR03862CC BY 4.0Reference data
L-aspartate+ATP+L-glutamine+waterAMP+L-asparagine+L-glutamate(1-)+proton+diphosphate(3-)
Catalysed by ASNS
Reaction pageLeft to rightBalancedEC 6.3.5.4cytosol
Human-GEM MAR03903CC BY 4.0Reference data
L-asparagine+waterL-aspartate+proton+ammonium
Reaction pageLeft to rightBalancedEC 3.5.1.1, 3.5.1.38cytosol
Human-GEM MAR04172CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
Transported by SLC36A1
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR05049CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05088CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05096CC BY 4.0Reference data
L-asparagine+ATP+MAM03065cAMP+Asn-tRNA(Asn)+diphosphate(3-)
Catalysed by NARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.22cytosol
Human-GEM MAR05133CC BY 4.0Reference data
MAM01308c+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by ALB
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05258CC BY 4.0Reference data
MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05259CC BY 4.0Reference data
MAM01343c+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05260CC BY 4.0Reference data
On the label
Labelled products
7 products
Source: NIH DSLD · Ingredient: L-asparagine · 7 products · Declared amount per serving: 4–2,230 mg (6 products)
6 labels state an amount1 does not
- Biotics Research CorporationAmino Sport4.5 mgper 3 Capsule(s)DSLD:21470
- Douglas LaboratoriesL-Asparagine 400 mg400 mgper 1 Capsule(s)DSLD:9146
- Drucker LabsintraMAX 2.0 Peach Mango Flavoramount not statedper 1 fl. Oz.DSLD:236722
- KirkmanAmino Support Powder90 mgper 1 tspDSLD:23882
- Mt. CapraDouble Bonded Protein Chocolate2,230 mgper 33.5 Gram(s)DSLD:19314
- Seeking HealthOptimal Amino Blend4 mgper 1 Capsule(s)DSLD:210883
- SuperSmartRehab100 mgper 2 Capsule(s)DSLD:332491
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
10 systems, 28 regions, 221 tissues, 404 transporter routes — routes, not measurements: transporters known to carry L-asparagine are expressed there, and no source reports it arriving.
Loading the model…
Other names
4 names
Resolves to: L-asparagine
- Also called
- (2S)-2-ammonio-3-carbamoylpropanoate(2S)-2-azaniumyl-3-carbamoylpropanoate(2S)-4-amino-2-ammonio-4-oxobutanoate
- Systematic name
- (2S)-4-amino-2-azaniumyl-4-oxobutanoate