Endpoint
Serum adiponectin
A 30-kDa complement C1Q-related protein, the most abundant gene product secreted by FAT cells of the white adipose tissue. Adiponectin modulates several physiological processes, such as metabolism of glucose and fatty acids, and immune responses. Decreased plasma adiponectin levels are associated with insulin resistance; type 2 diabetes mellitus; obesity; and atherosclerosis.
CAT:outcome/serum-adiponectinreported in micrograms/mL9 findings from 6 compounds
What moved it
How to read these marks9 findings · 6 compounds · 2 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| atorvastatin | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| pravastatin | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| curcumin | up | 3 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| resveratrol | no effect 1 · up 1 | 2 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| (-)-epigallocatechin 3-gallate | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| bisphenol A | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
7 findings
pravastatin — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“By pooling the results of the nine included comparisons, our meta-analysis showed that pravastatin treatment was associated with a significant increased level of circulating adiponectin as compared with controls (WMD =0.63 µg/mL; 95% CI, 0.17–1.09 µg/mL; P=0.007; Figure 2A), with moderate heterogeneity among the included studies (P for Cochrane’s Q test =0.20, I =28%).”
Quoted verbatim from Effect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Eight randomized controlled trials (nine comparisons) of patients with various disease statuses (hyperlipidemia, type 2 diabetes, metabolic syndrome, coronary artery disease), pravastatin versus control; total adiponectin measured by ELISA or radioimmunoassay
Effect 0.63 mean difference, 95% CI 0.17 to 1.09
Effect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials.2019PMID:31190742Permalink
curcumin — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001).”
Quoted verbatim from The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- adults, pooled across 6 RCTs (652 subjects) of curcumin supplementation vs placebo
Effect 0.82 standardised mean difference, 95% CI 0.33 to 1.3
The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials.2019PMID:31425942Permalink
curcumin — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“Our results showed that curcumin intervention significantly reduced pulse wave velocity, increased level of serum adiponectin and decreased level of leptin.”
Quoted verbatim from Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial.. - Study
- RCT
- Duration
- 6 months
- Population
- adults with type 2 diabetes
Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial.2014PMID:24445038Permalink
(-)-epigallocatechin 3-gallate — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Adiponectin presented a significantly higher level in the HFE group as compared with the HFW group (p = 0.031) and in the CE group as compared with the CW group (p = 0.046).”
Quoted verbatim from Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.. - Study
- animal · not in humans
- Duration
- 4 months
- Dose
- green tea extract 98% EGCG, 50 mg/kg/day by gavage
- Population
- Male Swiss mice after 16 weeks, 12-hour fasted; green tea extract versus water by gavage in both high-fat-diet mice (HFE vs HFW) and control-diet mice (CE vs CW)
Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.2015PMID:26536464Permalink
resveratrol — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Resveratrol significantly improves adiponectin but does not affect leptin concentrations.”
Quoted verbatim from Resveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Meta-analysis pooling 10 of 11 treatment arms from 9 randomized placebo-controlled trials of resveratrol supplementation
Resveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.2017PMID:28089943Permalink
bisphenol A — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Compared to negative controls, males in the BPA-5, BPA-50 and BPA-5000 groups had significantly lower serum adiponectin, with maximal reduction in the BPA-50 group.”
Quoted verbatim from Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.. - Study
- animal · not in humans
- Dose
- 5, 50 and 5000 ug/kg body weight/day to pregnant dams, GD 9 to 18
- Population
- Adult male CD-1 mice (19 weeks) exposed in utero via dams fed BPA once daily GD 9-18 in corn oil; dose strata BPA-5, BPA-50 and BPA-5000 ug/kg/day versus oil-only controls (the 500 and 50,000 ug/kg/day strata not significant); fed-state radioimmunoassay, 6-7 animals per group
Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.2013PMID:23892310Permalink
Show the remaining 1
curcumin — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“In conclusion, curcumin supplementation significantly increased circulating adiponectin and decreased leptin levels in adults.”
Quoted verbatim from The effect of curcumin supplementation on circulating adiponectin and leptin concentration in adults: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- adults
The effect of curcumin supplementation on circulating adiponectin and leptin concentration in adults: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials.2024PMID:37980942Permalink
Measured, no effect detected
2 findings
atorvastatin — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Meta-analysis with a random-effect model showed that atorvastatin did not significantly affect circulating adiponectin as compared with controls (WMD = − 0.27 μg/mL, 95% CI: − 0.89 to 0.35 μg/mL, p = 0.39; Fig. 2a).”
Quoted verbatim from Effect of atorvastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 10 to 80 mg/day, 4 to 30 weeks
- Population
- Patients with various conditions (hyperlipidaemia, type 2 diabetes, hypertension, coronary artery disease, rheumatoid arthritis) in ten randomised trials, 14 datasets, oral atorvastatin versus placebo or blank control
Effect -0.27 mean difference, 95% CI -0.89 to 0.35
Effect of atorvastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials.2019PMID:31870381Permalink
resveratrol — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“We found no significant effect of resveratrol administration on leptin (SMD = -0.20; 95% CI, -0.68, 0.27; P = 0.40; I2: 85.3) and adiponectin levels (SMD = 0.08; 95% CI, -0.39, 0.55; P = 0.74; I2: 91.0).”
Quoted verbatim from The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Adults across 36 pooled randomized controlled trials of resveratrol supplementation
Effect 0.08 standardised mean difference, 95% CI -0.39 to 0.55
The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials.2020PMID:30421960Permalink
How it is measured
Circulating adiponectin concentration in serum or plasma by immunoassay (ELISA). Whether the assay measures total adiponectin or the high-molecular-weight oligomer is recorded with each finding, along with species and fasting state.
Measured, not recorded
- Subject
- serum adiponectin
- Measurements
- 9 measurements
- Recorded as a finding
- No
Show what was measured
serum adiponectin
increases, gradually elevated, significantly different from placebo by final visit
Levels of adiponectin, an anti-inflammatory cytokine, in the placebo-treated group were virtually unchanged, whereas those of the curcumin-treated group were gradually elevated and became significantly different from that of placebo-treated group at the final visit (9 months) (Table 2).
PMID:22773702 · both readings recorded this
serum adiponectin
no effect
Adiponectin levels were similar for wild-type, AMPKα1−/−, and AMPKα2−/− mice and were not changed by resveratrol
PMID:19934007 · one of two readings recorded this
serum adiponectin
decreases
Compared to negative controls, males in the BPA-5, BPA-50 and BPA-5000 groups had significantly lower serum adiponectin, with maximal reduction in the BPA-50 group
PMID:23892310 · one of two readings recorded this
serum adiponectin
decreases
The level of TNF-α in the serum was increased while the Adip content decreased significantly, and there was an inverse relationship between the content of TNF-α and Adip
PMID:25703252 · one of two readings recorded this
Serum adiponectin
Adiponectin(μg/mL) | 8.38 ± 0.47 | 10.38 ± 0.66 * | 6.90 ± 1.01 | 8.73 ± 0.73 #
PMID:26536464 · one of two readings recorded this
Serum adiponectin
no effect
no change was seen in caffeine trials.
PMID:28967799 · one of two readings recorded this
serum adiponectin
increases
The changes in serum adiponectin levels were significantly higher in the "Yabukita" group at weeks 8 and 12 than in the placebo group.
PMID:29734777 · one of two readings recorded this
serum adiponectin
increases, SMD 1.44 (95% CI -0.13, 3.00)
Interestingly, pooled estimates showed that CoQ10 supplementation in individuals with metabolic syndrome increased adiponectin levels when compared to those on placebo (SMD: 1.44 [95% CI: −0.13, 3.00]; I2 = 96%, p < 0.00001).
PMID:32375340 · one of two readings recorded this
serum adiponectin
decreases, decrease at 'pre' point, significant within Ashwagandha group, n = 38
Analysis of the changes in adiponectin concentration induced by 8-week HIIT showed a significant interaction of time and term (p < 0.05).
PMID:41156498 · one of two readings recorded this
Sources cited
9 papers
- Subject
- serum adiponectin
- Findings
- 9
- Papers
- 9
The effect of curcumin supplementation on circulating adiponectin and leptin concentration in adults: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials.record2024PMID:379809421 finding
The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials.record2020PMID:304219601 finding
Effect of atorvastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials.record2019PMID:318703811 finding
Effect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials.record2019PMID:311907421 finding
The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials.record2019PMID:314259421 finding
Resveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.record2017PMID:280899431 finding
Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.record2015PMID:265364641 finding
Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial.record2014PMID:244450381 finding
Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.record2013PMID:238923101 finding