Compound
guanine
A 2-aminopurine carrying a 6-oxo substituent.
Definition from ChEBI (CHEBI:16235), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound
- Formula
- C5H5N5O
- Mass
- 151.129 g/mol
- Charge
- 0
- InChIKey
- UYTPUPDQBNUYGX-UHFFFAOYSA-N
- SMILES
- Nc1nc(=O)c2ncnc2n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- PNPProteinUNIPROT:P00491substrate ofInferred only108 paths36 endpoints
- HPRT1ProteinUNIPROT:P00492substrate ofInferred only54 paths27 endpoints
- SLC29A1ProteinUNIPROT:Q99808transported byInferred only43 paths43 endpoints
- SLC43A3ProteinUNIPROT:Q8NBI5transported byInferred only8 paths8 endpoints
- GDAProteinUNIPROT:Q9Y2T3substrate ofInferred only8 paths4 endpoints
- SLC29A2ProteinUNIPROT:Q14542transported byInferred only6 paths3 endpoints
- QTRT1ProteinUNIPROT:Q9BXR0substrate ofInferred only6 paths3 endpoints
- QTRT2ProteinUNIPROT:Q9H974substrate ofInferred only3 paths3 endpoints
What the reference databases state
Chemical structure
- acyclovir has the functional parent guanineCompoundChEBI CHEBI:2453Inferred only
- guanosine has the functional parent guanineCompoundChEBI CHEBI:16750Inferred only
Statements
17 statements
17 statements · 2 reference databases · Subject: guanine · Sources: Human-GEM, Rhea
- guanine is converted to xanthineCompoundRhea RHEA:14665Inferred only
- guanine is converted to xanthineCompoundHuman-GEM MAR04518Inferred only
- guanine is a substrate of GDAProteinHuman-GEM MAR04518Inferred only
- guanine is a substrate of GDAProteinRhea RHEA:14665Inferred only
- guanine is a substrate of HPRT1ProteinHuman-GEM MAR04452Inferred only
- guanine is a substrate of HPRT1ProteinRhea RHEA:25424Inferred only
- guanine is a substrate of PNPProteinRhea RHEA:27738Inferred only
- guanine is a substrate of PNPProteinHuman-GEM MAR04603Inferred only
- guanine is a substrate of PNPProteinHuman-GEM MAR04651Inferred only
- guanine is a substrate of QTRT1ProteinRhea RHEA:16633Inferred only
- guanine is a substrate of QTRT1ProteinHuman-GEM MAR09518Inferred only
- guanine is a substrate of QTRT2ProteinHuman-GEM MAR09518Inferred only
Show the remaining 5
- guanine is transported by SLC29A1ProteinRhea RHEA:71531Inferred only
- guanine is transported by SLC29A2ProteinHuman-GEM MAR04985Inferred only
- guanine is transported by SLC29A2ProteinRhea RHEA:71531Inferred only
- guanine is transported by SLC29A3ProteinRhea RHEA:71531Inferred only
- guanine is transported by SLC43A3ProteinRhea RHEA:71531Inferred only
Reactions
23 reactions
guanine+5-phospho-alpha-D-ribose 1-diphosphateGMP+diphosphate(3-)
Catalysed by HPRT1
Reaction pageLeft to rightBalancedEC 2.4.2.8cytosol
Human-GEM MAR04452CC BY 4.0Reference data
guanine+waterammonium+xanthine
Catalysed by GDA
Reaction pageLeft to rightBalancedEC 3.5.4.3cytosol
Human-GEM MAR04518CC BY 4.0Reference data
MAM00639c+guanine2'-deoxyguanosine+phosphate(3-)
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1, 2.4.2.4cytosol
Human-GEM MAR04603CC BY 4.0Reference data
guanosine+phosphate(3-)guanine+D-ribose 1-phosphate
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.15, 2.4.2.1cytosol
Human-GEM MAR04651CC BY 4.0Reference data
Transported by SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04985CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09353CC BY 4.0Reference data
guanine+MAM03086cqueuine+MAM03084c
Reaction pageReversibleBalance undeterminableEC 2.4.2.29cytosol
Human-GEM MAR09518CC BY 4.0Reference data
guanosine+hydrogenphosphatealpha-D-ribose 1-phosphate+guanine
Reaction pageLeft to rightBalanced
Rhea RHEA:13233CC BY 4.0Reference data
guanine+water+hydronxanthine+ammonium
Catalysed by GDA
Reaction pageLeft to rightBalanced
Rhea RHEA:14665CC BY 4.0Reference data
CHEBI:74269+queuineCHEBI:194431+guanine
Catalysed by QTRT1
Reaction pageDirection not assertedBalanced
Rhea RHEA:16633CC BY 4.0Reference data
guanine+ATP(4-)+waterguanine+ADP(3-)+hydrogenphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:20832CC BY 4.0Reference data
CHEBI:58703+CHEBI:74269CHEBI:82833+guanine
Reaction pageDirection not assertedBalanced
Rhea RHEA:24104CC BY 4.0Reference data
Where it reaches
6 systems, 16 regions, 46 tissues, 51 transporter routes — routes, not measurements: transporters known to carry guanine are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: guanine
- Also called
- 2-Amino-6-hydroxypurine2-amino-6-oxopurineGua
- Systematic name
- 2-amino-1,9-dihydro-6H-purin-6-one