Endpoint

Serum or plasma lutein concentration

CAT:outcome/serum-lutein-concentrationreported in micromol/L2 findings from 1 compound

What moved it

2 findings · 1 compound · by evidence strength

Compound	Direction	Findings	Strongest evidence
lutein	up	2	Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.

Reported to move it

2 findings

lutein — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1
“Total lutein + zeaxanthin concentrations were greater in the low- and high-dose-supplemented groups than in the placebo group in breast milk (140% and 250%, respectively; P < 0.0001), maternal plasma (170% and 250%, respectively; P < 0.0001), and infant plasma (180% and 330%, respectively; P < 0.05).”
Quoted verbatim from Lutein supplementation increases breast milk and plasma lutein concentrations in lactating women and infant plasma concentrations but does not affect other carotenoids..
Study

RCT
Population

Lactating women 4-6 weeks postpartum given lutein supplement at low dose or high dose versus placebo; the claim is the maternal plasma concentration, lutein and zeaxanthin reported as a combined figure
Lutein supplementation increases breast milk and plasma lutein concentrations in lactating women and infant plasma concentrations but does not affect other carotenoids.2014PMID:24899160Permalink
lutein — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1
“A statistically significant increase in plasma lutein and zeaxanthin was shown in the L + Z group after 3 months and 6 months of treatment compared with the placebo group.”
Quoted verbatim from Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial..
Study

RCT
Duration

6 months
Dose

2 daily dietary supplementation capsules
Population

First-generation offspring of parents with neovascular AMD (LIMPIA trial); lutein and zeaxanthin reported as a combined plasma figure.
Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial.2017PMID:28973076Permalink

How it is measured

Lutein concentration in serum or plasma by high-performance liquid chromatography, fasting state and matrix recorded with each finding. Where a study reports lutein and zeaxanthin as a combined figure that is recorded as such, since the two are separated by most but not all assays.

Sources cited

2 papers

Subject: serum or plasma lutein concentration
Findings: 2
Papers: 2

Compound

Direction

Findings

Strongest evidence

lutein