Compound

Collagen

Pinned after ADR-0012 found it: collagen was on the 'unrepresentable' list purely because nobody looked it up. 'Collagen peptides' is hydrolysed collagen — a PREPARATION recorded on the edge, not a separate node.

CHEBI:3815ChEBI

Studied for

1 endpoint, 1 finding, from 1 paper.

Stratum corneum hydration (corneometry)raisesGrade B, Likely. Human evidence, limited replication or design limits.

Every finding, with the quotes

Structure

Two-dimensional depiction. Bond angles are a drawing convention, not geometry.

Class: Structural class, not a single molecule
Formula: C4H6N2O3R2(C7H9N2O2R)n
SMILES: *C(N)C(=O)N[C@H](*)C(=O)N1CCC[C@H]1C(=O)NC(*)C(=O)O
Look it up: ChEBI

Identity from ChEBI. Not evidence — none of it carries a grade.

What the evidence says

How to read these marks

1 finding across 1 endpoint, from 1 paper, strongest first.

Heavier lines are better evidence, and a line with a gap in the middle is an inference rather than a reported result. Two lines arriving at one endpoint are two findings of it, marked ×2. How a grade is computed.

What moved

1 finding

Increases stratum corneum hydration (corneometry)
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding
“The overall pooled effect size of 0.63 (95% CI 0.38, 0.88) indicated that HC supplementation significantly improved skin hydration (z = 4.94, p < 0.00001).”
Quoted verbatim from Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis..
Study

meta-analysis
Population

healthy adults, pooled across 18 of 26 included RCTs of oral hydrolyzed collagen (HC) supplementation, for skin hydration
Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis.2023PMID:37432180