Compound
taurocholate
The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C26H44NO7S
- Mass
- 514.705 g/mol
- Charge
- -1
- InChIKey
- WBWWGRHZICKQGZ-HZAMXZRMSA-M
- SMILES
- [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CCC(=O)NCCS(=O)(=O)[O-])[C@]1([H])[C@H](O)C2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
16 entities
16 entities reached.
0 reported hops16 assembled from the scaffold
- ABCA8ProteinUNIPROT:O94911transported byInferred only147 paths48 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only66 paths30 endpoints
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only24 paths24 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only20 paths10 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only18 paths9 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only17 paths2 endpoints
- SLCO4A1ProteinUNIPROT:Q96BD0transported byInferred only12 paths4 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only10 paths5 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only8 paths3 endpoints
- SLC10A1ProteinUNIPROT:Q14973transported byInferred only6 paths2 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only6 paths2 endpoints
- SLC10A2ProteinUNIPROT:Q12908transported byInferred only4 paths2 endpoints
Show the remaining 4
What the reference databases state
Statements
45 statements
45 statements · 2 reference databases · Subject: taurocholate · Sources: Human-GEM, Rhea
- taurocholate is metabolised by SULT2A1ProteinHuman-GEM MAR12286Inferred only
- taurocholate is transported by ABCA8ProteinRhea RHEA:65964Inferred only
- taurocholate is transported by ABCA8ProteinHuman-GEM MAR09906Inferred only
- taurocholate is transported by ABCA8ProteinRhea RHEA:50052Inferred only
- taurocholate is transported by ABCB11ProteinHuman-GEM MAR01870Inferred only
- taurocholate is transported by ABCB11ProteinRhea RHEA:50052Inferred only
- taurocholate is transported by ABCC11ProteinRhea RHEA:50052Inferred only
- taurocholate is transported by ABCC11ProteinHuman-GEM MAR01870Inferred only
- taurocholate is transported by ABCC3ProteinRhea RHEA:50052Inferred only
- taurocholate is transported by ABCC3ProteinHuman-GEM MAR01870Inferred only
- taurocholate is transported by ABCC4ProteinHuman-GEM MAR01870Inferred only
- taurocholate is transported by ABCC4ProteinRhea RHEA:66404Inferred only
Show the remaining 33
- taurocholate is transported by SLC10A1ProteinRhea RHEA:71875Inferred only
- taurocholate is transported by SLC10A1ProteinHuman-GEM MAR01855Inferred only
- taurocholate is transported by SLC10A1ProteinHuman-GEM MAR01865Inferred only
- taurocholate is transported by SLC10A2ProteinRhea RHEA:71875Inferred only
- taurocholate is transported by SLC10A2ProteinHuman-GEM MAR01865Inferred only
- taurocholate is transported by SLC22A24ProteinRhea RHEA:72159Inferred only
- taurocholate is transported by SLC22A8ProteinRhea RHEA:72547Inferred only
- taurocholate is transported by SLC22A8ProteinRhea RHEA:72159Inferred only
- taurocholate is transported by SLC46A3ProteinRhea RHEA:75507Inferred only
- taurocholate is transported by SLC51AProteinHuman-GEM MAR01870Inferred only
- taurocholate is transported by SLC51AProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLC51BProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLC51BProteinHuman-GEM MAR01870Inferred only
- taurocholate is transported by SLCO1A2ProteinHuman-GEM MAR01889Inferred only
- taurocholate is transported by SLCO1A2ProteinHuman-GEM MAR01891Inferred only
- taurocholate is transported by SLCO1A2ProteinHuman-GEM MAR01890Inferred only
- taurocholate is transported by SLCO1A2ProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLCO1A2ProteinHuman-GEM MAR01878Inferred only
- taurocholate is transported by SLCO1A2ProteinHuman-GEM MAR01877Inferred only
- taurocholate is transported by SLCO1B1ProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLCO1B1ProteinHuman-GEM MAR01878Inferred only
- taurocholate is transported by SLCO1B3ProteinHuman-GEM MAR01891Inferred only
- taurocholate is transported by SLCO1B3ProteinHuman-GEM MAR01889Inferred only
- taurocholate is transported by SLCO1B3ProteinHuman-GEM MAR01890Inferred only
- taurocholate is transported by SLCO1B3ProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLCO1B3ProteinHuman-GEM MAR01877Inferred only
- taurocholate is transported by SLCO1B3ProteinHuman-GEM MAR01878Inferred only
- taurocholate is transported by SLCO1B3-SLCO1B7ProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLCO2B1ProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLCO3A1ProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLCO4A1ProteinHuman-GEM MAR01878Inferred only
- taurocholate is transported by SLCO4A1ProteinRhea RHEA:71703Inferred only
- taurocholate is transported by SLCO4A1ProteinRhea RHEA:72307Inferred only
Reactions
42 reactions
CHEBI:15519+taurineCHEBI:1146900+taurocholate
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65peroxisome
Human-GEM MAR01667CC BY 4.0Reference data
CHEBI:15519+taurineCHEBI:1146900+taurocholate
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65cytosol
Human-GEM MAR01668CC BY 4.0Reference data
Reaction pageReversibleBalancedEC 6.2.1.5extracellular space, cytosol
Human-GEM MAR01731CC BY 4.0Reference data
Reaction pageReversibleBalancedEC 3.2.1.26peroxisome, cytosol
Human-GEM MAR01732CC BY 4.0Reference data
sodium(1+)+taurocholatesodium(1+)+taurocholate
Transported by SLC10A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01855CC BY 4.0Reference data
2ATP+2water+taurocholate2ADP+2proton+2phosphate(3-)+taurocholate
Reaction pageLeft to rightBalancedperoxisome, extracellular space
Human-GEM MAR01857CC BY 4.0Reference data
2sodium(1+)+taurocholate2sodium(1+)+taurocholate
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01865CC BY 4.0Reference data
ATP+water+taurocholateADP+proton+phosphate(3-)+taurocholate
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01870CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+taurocholateCHEBI:16856+hydrogencarbonate+taurocholate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01877CC BY 4.0Reference data
hydrogencarbonate+taurocholatehydrogencarbonate+taurocholate
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01878CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+taurocholateMAM01980e+hydrogencarbonate+taurocholate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR01889CC BY 4.0Reference data
hydrogencarbonate+2,4-dinitrophenyl-S-glutathione+taurocholatehydrogencarbonate+2,4-dinitrophenyl-S-glutathione+taurocholate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01890CC BY 4.0Reference data
Where it reaches
9 systems, 24 regions, 81 tissues, 119 transporter routes — routes, not measurements: transporters known to carry taurocholate are expressed there, and no source reports it arriving.
Loading the model…
Other names
2 names
Resolves to: taurocholate
- Systematic name
- 2-[(3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonate2-[(3α,7α,12α-trihydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonate