Compound
CHEBI:18095
A hydroxylated form of the imino acid proline. A deficiency in ascorbic acid can result in impaired hydroxyproline formation.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- PYCR1ProteinUNIPROT:P32322substrate ofInferred only64 paths16 endpoints
- SLC1A4ProteinUNIPROT:P43007transported byInferred only32 paths32 endpoints
- PYCR3ProteinUNIPROT:Q53H96substrate ofInferred only20 paths5 endpoints
- PYCR2ProteinUNIPROT:Q96C36substrate ofInferred only20 paths5 endpoints
- CLTRNProteinUNIPROT:Q9HBJ8transported byInferred only1 path1 endpoint
- SLC6A20ProteinUNIPROT:Q9NP91transported byInferred only1 path1 endpoint
What the reference databases state
Statements
22 statements
22 statements · 1 reference database · Subject: CHEBI:18095 · Sources: Human-GEM
- CHEBI:18095 is converted to (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateCompoundHuman-GEM MAR04778Inferred only
- CHEBI:18095 is converted to (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateCompoundHuman-GEM MAR04779Inferred only
- CHEBI:18095 is converted to (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateCompoundHuman-GEM MAR04780Inferred only
- CHEBI:18095 is converted to (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateCompoundHuman-GEM MAR04781Inferred only
- CHEBI:17203 is converted to CHEBI:18095CompoundHuman-GEM MAR01649Inferred only
- CHEBI:17203 is converted to CHEBI:18095CompoundHuman-GEM MAR04776Inferred only
- CHEBI:17203 is converted to CHEBI:18095CompoundHuman-GEM MAR04777Inferred only
- CHEBI:18095 is a substrate of PYCR1ProteinHuman-GEM MAR04781Inferred only
- CHEBI:18095 is a substrate of PYCR1ProteinHuman-GEM MAR04779Inferred only
- CHEBI:18095 is a substrate of PYCR1ProteinHuman-GEM MAR04780Inferred only
- CHEBI:18095 is a substrate of PYCR1ProteinHuman-GEM MAR04778Inferred only
- CHEBI:18095 is a substrate of PYCR2ProteinHuman-GEM MAR04781Inferred only
Show the remaining 10
- CHEBI:18095 is a substrate of PYCR2ProteinHuman-GEM MAR04778Inferred only
- CHEBI:18095 is a substrate of PYCR2ProteinHuman-GEM MAR04780Inferred only
- CHEBI:18095 is a substrate of PYCR2ProteinHuman-GEM MAR04779Inferred only
- CHEBI:18095 is a substrate of PYCR3ProteinHuman-GEM MAR04781Inferred only
- CHEBI:18095 is a substrate of PYCR3ProteinHuman-GEM MAR04778Inferred only
- CHEBI:18095 is a substrate of PYCR3ProteinHuman-GEM MAR04780Inferred only
- CHEBI:18095 is a substrate of PYCR3ProteinHuman-GEM MAR04779Inferred only
- CHEBI:18095 is transported by CLTRNProteinHuman-GEM MAR06860Inferred only
- CHEBI:18095 is transported by SLC1A4ProteinHuman-GEM MAR07753Inferred only
- CHEBI:18095 is transported by SLC6A20ProteinHuman-GEM MAR06860Inferred only
Reactions
11 reactions
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HB & P4HA1 or P4HA2 & P4HB
Reaction pageLeft to rightBalancedEC 1.14.11.2GO:0005783
Human-GEM MAR01649CC BY 4.0Reference data
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HA2 or P4HA1 or P4HA3
Reaction pageLeft to rightBalancedEC 1.14.11.2GO:0005829
Human-GEM MAR04776CC BY 4.0Reference data
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HA2 or P4HA1 or P4HA3
Reaction pageLeft to rightBalancedEC 1.14.11.2GO:0005759
Human-GEM MAR04777CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2GO:0005829
Human-GEM MAR04778CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2GO:0005759
Human-GEM MAR04779CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2GO:0005829
Human-GEM MAR04780CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2GO:0005759
Human-GEM MAR04781CC BY 4.0Reference data
chlorine(.)+2sodium(1+)+CHEBI:18095chlorine(.)+2sodium(1+)+CHEBI:18095
Transported by CLTRN & SLC6A20
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR06860CC BY 4.0Reference data
L-alanine+sodium(1+)+CHEBI:18095L-alanine+sodium(1+)+CHEBI:18095
Transported by SLC1A4
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR07753CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR08386CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005615, GO:0005759
Human-GEM MAR09002CC BY 4.0Reference data
Where it reaches
8 systems, 15 regions, 31 tissues, 31 transporter routes — routes, not measurements: transporters known to carry CHEBI:18095 are expressed there, and no source reports it arriving.
Loading the model…
Other names
14 names
Resolves to: CHEBI:18095
- Also called
- (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid(2S,4R)-trans-4-hydroxyprolinedelta-hydroxyprolineHydroxy-L-prolineHydroxyprolineHypHyproL-4-HydroxyprolineL-threo-4-hydroxyprolinetrans-4-hydroxy-L-prolinetrans-Hydroxyprolinetrans-L-Hydroxyprolineδ-hydroxyproline
- Systematic name
- (4R)-4-hydroxy-L-proline