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Catalyst

knowcompounds2-oxoglutaric acid

Specimen compound organic compoundPlate I

2-oxoglutaric acid

Nested hairline contours trace the electron density of one computed shape of 2-oxoglutaric acid, teal at the edge warming to amber over the atoms.
fig. 12-oxoglutaric acid · electron density · PubChem CID 51, computed 3D conformer
Formula
C5H6O5
Molar mass
146.098 g/mol
PubChem CID
51
InChIKey
KPGXRSRHYNQIFN-UHFFFAOYSA-N

↓ lowered

01 · the evidence, ordered

What the evidence says

Fig. 2 2-oxoglutaric acid CHEBI:30915 1 endpoint its finding
×1.60
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2-oxoglutaric acid

8 compounds on the outer ring, not drawn

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02 · findings

What 2-oxoglutaric acid moved, and by how much

  • Dose studied: as its paper gave it.
  • Evidence strength: computed from the study. How it is computed
  1. Serum albuminMoved: lowersEvidence: Very limitedPaper: PMID 122972062002
    Who
    Patients after elective abdominal surgery receiving enteral nutrition for 5 days; both arms received enteral nutrition, the intervention arm's solution enriched with alpha-ketoglutarate
    Dose studied
    alpha-ketoglutarate enrichment of enteral formula, 5 days postoperatively; amount not stated in abstract

    Transthyretin decreased by 25% in both groups, and albumin decreased significantly in the enriched group compared with the standard nutrition.”

    Quoted verbatim from Alpha-ketoglutarate-supplemented enteral nutrition: effects on postoperative nitrogen balance and muscle catabolism.RCT · 5 daysPermalink

No dose is advised.

  • Dose studied: as its paper gave it.
  • Evidence strength: computed from the study. How it is computed

03 · identity

Structure

fig. 32-oxoglutaric acid · 2D structure · ChEBI’s SMILES
Charge
0
SMILES
O=C(O)CCC(=O)C(=O)O

04 · on the label · 125 products

Labelled products

Source: NIH DSLD · Ingredient: 2-oxoglutaric acid · 125 products · Declared amount per serving: 2–1,330 mg

61 labels state an amount64 do not

  • All American EFXNytric EFX ProArginine Alpha-Ketoglutarate1 gper 1 tabletDSLD:629
  • Allergy Research GroupNTFactor Advanced Physicians Formula300 mgper 5 tabletsDSLD:233555
  • Allergy Research GroupNTFactor Healthy Aging50 mgper 2 tabletsDSLD:233416
  • Beachbody NutritionalsActiVit Body Toning Formula2 mgper 2 tabletsDSLD:6828
  • Beachbody NutritionalsActiVit Metabolism Formula2 mgper 2 tabletsDSLD:6824
  • Beverly InternationalMuscle Synergy Lemonamount not statedper 27 gDSLD:332850
  • Beyond HealthNatural Amino hGHamount not statedper 7 capsulesDSLD:306896
  • BulkSupplements.comAAKG (L-Arginine Alpha-Ketoglutarate)739 mgper 2500 mgDSLD:312823
  • BulkSupplements.comAAKG (L-Arginine Alpha-Ketoglutarate)739 mgper 2500 mgDSLD:312824
  • BulkSupplements.comAAKG (L-Arginine Alpha-Ketoglutarate)739 mgper 2500 mgDSLD:312825
  • BulkSupplements.comAAKG (L-Arginine Alpha-Ketoglutarate)739 mgper 2500 mgDSLD:312826
  • Cardiovascular ResearchHepagen40 mgper 1 capsuleDSLD:304390
Show the remaining 113Show the first 12

Label record: NIH Office of Dietary Supplements · CC0

05 · the record

Sources

10

papers screened for 2-oxoglutaric acid

admitted
1
read and discarded
8
not read yet
1

The screening record, every paper and why

Documented interactions
None reported

Sources cited

1 paper · 1 finding

Show every paper citedHide the papers cited
65Endpoints measured, not recorded as findingsEvery row, on one page
9Papers indexed under 2-oxoglutaric acid