Compound
D-galactose
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (galactose-1-phosphate uridyl-transferase deficiency disease) causes an error in galactose metabolism called galactosemia, resulting in elevations of galactose in the blood.
Structure
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- Class
- Organic compound
- Formula
- C6H12O6
- Mass
- 180.156 g/mol
- Charge
- 0
- InChIKey
- WQZGKKKJIJFFOK-SVZMEOIVSA-N
- SMILES
- OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- SLC2A3ProteinUNIPROT:P11169transported byInferred only22 paths22 endpoints
- AKR1B1ProteinUNIPROT:P15121substrate ofInferred only22 paths22 endpoints
- SLC2A2ProteinUNIPROT:P11168transported byInferred only6 paths5 endpoints
- SLC45A1ProteinUNIPROT:Q9Y2W3transported byInferred only5 paths5 endpoints
- SLC5A1ProteinUNIPROT:P13866transported byInferred only5 paths4 endpoints
- DHDHProteinUNIPROT:Q9UQ10substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
17 statements
17 statements · 1 reference database · Subject: D-galactose · Sources: Rhea
- alpha-D-galactose 1-phosphate is converted to D-galactoseCompoundRhea RHEA:29315Inferred only
- D-galactono-1,5-lactone is converted to D-galactoseCompoundRhea RHEA:59312Inferred only
- D-galactose is converted to D-galactono-1,5-lactoneCompoundRhea RHEA:18625Inferred only
- D-galactose is converted to D-galactono-1,5-lactoneCompoundRhea RHEA:42392Inferred only
- D-galactose is converted to D-galactono-1,5-lactoneCompoundRhea RHEA:59312Inferred only
- D-galactono-1,5-lactone is converted to D-galactoseCompoundRhea RHEA:18625Inferred only
- D-galactono-1,5-lactone is converted to D-galactoseCompoundRhea RHEA:42392Inferred only
- galactitol is converted to D-galactoseCompoundRhea RHEA:37963Inferred only
- galactitol is converted to D-galactoseCompoundRhea RHEA:37967Inferred only
- D-galactose is converted to galactitolCompoundRhea RHEA:37963Inferred only
- D-galactose is converted to galactitolCompoundRhea RHEA:37967Inferred only
- D-galactose is a substrate of AKR1B1ProteinRhea RHEA:37967Inferred only
Show the remaining 5
- D-galactose is a substrate of DHDHProteinRhea RHEA:18625Inferred only
- D-galactose is transported by SLC2A2ProteinRhea RHEA:34915Inferred only
- D-galactose is transported by SLC2A3ProteinRhea RHEA:34915Inferred only
- D-galactose is transported by SLC45A1ProteinRhea RHEA:29019Inferred only
- D-galactose is transported by SLC5A1ProteinRhea RHEA:70499Inferred only
Reactions
33 reactions
a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine+waterD-galactose+an N-acylsphing-4-enine
Catalysed by GBA1 or GALC or GBA3 or GBA2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:14297CC BY 4.0Reference data
D-galactose+NADP(3-)D-galactono-1,5-lactone+NADPH(4-)+hydron
Catalysed by DHDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:18625CC BY 4.0Reference data
a globoside Gb3Cer (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+D-galactose
Catalysed by GLA
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21112CC BY 4.0Reference data
D-galactose+NAD(1-)CHEBI:15895+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:21296CC BY 4.0Reference data
D-galactose+dioxygenCHEBI:16222+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:24160CC BY 4.0Reference data
CHEBI:28053+waterD-galactose+D-glucose
Reaction pageDirection not assertedBalanced
Rhea RHEA:28663CC BY 4.0Reference data
D-galactose+hydronD-galactose+hydron
Transported by SLC45A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:29019CC BY 4.0Reference data
alpha-D-galactose 1-phosphate+waterD-galactose+hydrogenphosphate
Catalysed by IMPA1
Reaction pageLeft to rightBalanced
Rhea RHEA:29315CC BY 4.0Reference data
Transported by SLC2A2 or SLC2A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:34915CC BY 4.0Reference data
galactitol+NAD(1-)D-galactose+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:37963CC BY 4.0Reference data
galactitol+NADP(3-)D-galactose+NADPH(4-)+hydron
Catalysed by AKR1B1
Reaction pageDirection not assertedBalanced
Rhea RHEA:37967CC BY 4.0Reference data
D-galactose+NAD(1-)D-galactono-1,5-lactone+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:42392CC BY 4.0Reference data
Where it reaches
7 systems, 13 regions, 31 tissues, 34 transporter routes — routes, not measurements: transporters known to carry D-galactose are expressed there, and no source reports it arriving.
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Other names
1 name
Resolves to: D-galactose
- Systematic name
- D-galactopyranose