Endpoint
Stool frequency
CAT:outcome/stool-frequencyreported in stools/day1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-glutamine | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
L-glutamine — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Glutamine also (i) reduced daily bowel movement frequency (p<0.0001), (ii) improved stool form on the Bristol Stool Scale (p<0.0001), and (iii) normalized intestinal hyperpermeability (where hyperpermeability is defined as an elevated urinary lactulose/mannitol ratio > 0.07) (p<0.0001).”
Quoted verbatim from Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.. - Study
- RCT
- Participants
- 106
- Duration
- 8 weeks
- Dose
- glutamine powder 5 g orally three times daily for 8 weeks
- Population
- adults with post-infectious diarrhoea-predominant IBS (IBS-D) and intestinal hyperpermeability
Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.2019PMID:30108163Permalink
How it is measured
Number of stools passed per 24 hours, recorded in a participant- or caregiver-completed bowel diary over a stated observation period. The diary duration, and whether stool form was scored separately on the Bristol Stool Form Scale, are recorded with each finding.
Measured, not recorded
- Subject
- stool frequency
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
stool frequency
increases, p = 0.006
Stool frequency was moderately increased in the isomalt phase (P=0.006)
PMID:16197583 · one of two readings recorded this
Sources cited
1 paper
- Subject
- stool frequency
- Findings
- 1
- Papers
- 1