Skip to content
Catalyst

knowcompoundssulfonyldimethane

Specimen compound organic compoundPlate I

Sulfonyldimethane

Nested hairline contours trace the electron density of one computed shape of sulfonyldimethane, teal at the edge warming to amber over the atoms.
fig. 1Sulfonyldimethane · electron density · PubChem CID 6213, computed 3D conformer
Formula
C2H6O2S
Molar mass
94.135 g/mol
ChEBI
CHEBI:9349
PubChem CID
6213
InChIKey
HHVIBTZHLRERCL-UHFFFAOYSA-N

↑ raised 1 finding in 1 endpoint · ↓ lowered 4 in 4 · – no difference found 3 in 3

01 · the evidence, ordered

What the evidence says

Strong
0
Moderate
2
Limited
2
Very limited
4
Insufficient
0

How to read these marks

Fig. 2 Sulfonyldimethane CHEBI:9349 6 endpoints 8 findings
×1.60
Labels
CompoundInspector

Sulfonyldimethane

Most findings

  • C-reactive protein concentration×2
  • Total antioxidant capacity×2
  • Interleukin-6 concentration×1
  • Malondialdehyde (circulating)×1
  • WOMAC pain subscale×1
  • WOMAC physical function subscale×1

36 compounds on the outer ring, not drawn

Keys

← → round a ring↑ ↓ out and inEnter selecte the outer ringf fit to view+ − zoomEsc clearclick a node to select it

  1. C-reactive protein concentrationcontested
  2. Interleukin-6 concentration
  3. Total antioxidant capacitycontested
  4. Malondialdehyde (circulating)
  5. WOMAC pain subscale
  6. WOMAC physical function subscale
fig. 3 · 6 endpoints · 8 findingscontested · an endpoint whose findings disagree

02 · contested · 2 endpoints

Where the findings disagree

  1. 012 findings

    C-reactive protein concentration

    ↓ lowered
    1
    – no difference found
    1

  2. 022 findings

    Total antioxidant capacity

    – no difference found
    1
    ↑ raised
    1

03 · findings

What sulfonyldimethane moved, and by how much

  • Dose studied: as its paper gave it.
  • Evidence strength: computed from the study. How it is computed
  • Industry funding: named on its row.
Direction
Strength, at least

8 shown

  1. Interleukin-6 concentrationMoved: no difference foundEvidence: ModeratePaper: PMID 374473222023
    Who
    Healthy Japanese adults with mild knee pain (Kellgren-Lawrence grade 0 or 1); per-protocol set; change from baseline at each visit up to 12 weeks
    Dose studied
    10 tablets per day, 200 mg MSM per tablet, vs lactose tablets

    There was also no significant difference in the amount of change in IL-1 beta, IL-6, and Hs-CRP between the MSM and placebo groups during any week of comparison (Supplementary Table S2).”

    Quoted verbatim from Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.RCT · 3 monthsPermalink
  2. C-reactive protein concentrationcontestedMoved: no difference foundEvidence: ModeratePaper: PMID 374473222023
    Who
    Healthy Japanese adults with mild knee pain (Kellgren-Lawrence grade 0 or 1); per-protocol set; change from baseline at each visit up to 12 weeks
    Dose studied
    10 tablets per day, 200 mg MSM per tablet, vs lactose tablets

    There was also no significant difference in the amount of change in IL-1 beta, IL-6, and Hs-CRP between the MSM and placebo groups during any week of comparison (Supplementary Table S2).”

    Quoted verbatim from Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.RCT · 3 monthsPermalink
  3. C-reactive protein concentrationcontestedMoved: lowersEvidence: LimitedPaper: PMID 346846212021Industry funded
    Who
    Healthy overweight or obese adults (BMI 25 or above), 22 completers; week 16 timepoint
    Dose studied
    3 g/day MSM (OptiMSM) vs placebo capsules of white rice flour

    CRP was significantly lower in MSM compared to placebo at week 16 (p = 0.04).”

    Quoted verbatim from The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial.RCT · 4 monthsPermalink
  4. Total antioxidant capacitycontestedMoved: no difference foundEvidence: LimitedPaper: PMID 346846212021Industry funded
    Who
    Healthy overweight or obese adults (BMI 25 or above), 22 completers
    Dose studied
    3 g/day MSM (OptiMSM) vs placebo capsules of white rice flour

    The total antioxidant capacity of the serum was not different between the MSM and placebo group (Table 3).”

    Quoted verbatim from The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial.RCT · 4 monthsPermalink
  5. WOMAC pain subscaleMoved: lowersEvidence: Very limitedPaper: PMID 163099282006
    Who
    Fifty men and women, 40-76 years of age with knee osteoarthritis pain; WOMAC visual analogue scale format · n = 50
    Dose studied
    MSM 3 g twice a day (6 g/day total) for 12 weeks

    Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05).”

    Quoted verbatim from Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.RCT · 3 monthsPermalink
  6. WOMAC physical function subscaleMoved: lowersEvidence: Very limitedPaper: PMID 163099282006
    Who
    Fifty men and women, 40-76 years of age with knee osteoarthritis pain; WOMAC visual analogue scale format · n = 50
    Dose studied
    MSM 3 g twice a day (6 g/day total) for 12 weeks

    Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05).”

    Quoted verbatim from Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.RCT · 3 monthsPermalink
  7. Total antioxidant capacitycontestedMoved: raisesEvidence: Very limitedPaper: PMID 225256532012
    Who
    Eighteen healthy, non-smoking, active young men who ran 14 km after 10 days of supplementation; result at 2 h and 24 h after exercise · n = 18
    Dose studied
    50 mg/kg MSM in 200 mL water daily for 10 days

    TAC showed significant increase in M group 2 and 24 h after exercise compared to P group (P=0.014 and P=0.033, respectively).”

    Quoted verbatim from Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity.RCT · 10 daysPermalink
  8. Malondialdehyde (circulating)Moved: lowersEvidence: Very limitedPaper: PMID 218995442011
    Who
    Eighteen untrained healthy young men who ran 14 km after 10 days of supplementation; serum MDA after exercise · n = 18
    Dose studied
    MSM prepared in water at 50 mg/kg body weight daily for 10 days

    MSM supplementation maintained PC, MDA and GSSG at lower levels after exercise than the placebo.”

    Quoted verbatim from Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men.RCT · 10 daysPermalink

No dose is advised.

  • Dose studied: as its paper gave it.
  • Evidence strength: computed from the study. How it is computed
  • Industry funding: named on its row.

04 · identity

Structure

fig. 4Sulfonyldimethane · 2D structure · ChEBI’s SMILES
Charge
0
SMILES
CS(C)(=O)=O

05 · on the label · 1,824 products

Labelled products

Source: NIH DSLD · Ingredient: sulfonyldimethane · 1,824 products · Declared amount per serving (the first 1,000 shown): 6–240,000 mg · 1 amount above the serving weight, left out

812 labels of the first 1,000 shown state an amount188 do not

  • 1 BodyHair Skin & Nails300 mgper 2 vegan capsulesDSLD:257257
  • 1 BodyJoint Support100 mgper 3 tabletsDSLD:257252
  • 1st PhormHair Skin Nail Essentials240 mgper 3 vegan capsulesDSLD:242797
  • 21st CenturyArthri-Flex Advantage + Vitamin D31,500 mgper 2 tabletsDSLD:207404
  • 21st CenturyGlucosamine & Chondroitin plus Hyaluronic Acid + MSM500 mgper 1 tabletDSLD:207477
  • 21st CenturyGlucosamine Chondroitin Advanced plus 1500 mg MSM1,500 mgper 3 tabletsDSLD:207411
  • 21st CenturyGlucosamine Chondroitin Complex plus MSM Advanced Triple Strengthamount not statedper 2 tabletsDSLD:206833
  • 21st CenturyMaximum Strength Glucosamine & Chondroitin Plus500 mgper 1 tabletDSLD:11284
  • 21st CenturyMaximum Strength Glucosamine & Chondroitin Plus500 mgper 1 tabletDSLD:11286
  • 21st CenturyMSM1,000 mgper 1 tabletDSLD:233576
  • 21st CenturyMSM 1000 mg1,000 mgper 1 tabletDSLD:258476
  • 365 Everyday ValueGlucosamine Chondroitin & MSM500 mgper 3 capsulesDSLD:207602
Show the remaining 1,812Show the first 12
Every product, as data

Label record: NIH Office of Dietary Supplements · CC0

06 · the record

Sources

25

papers screened for sulfonyldimethane

admitted
6
read and discarded
11
not read yet
8

The screening record, every paper and why

Documented interactions
None reported

Sources cited

5 papers · 8 findings

1 admitted at screening, no finding yet

Show every paper citedHide the papers cited
244Endpoints measured, not recorded as findingsEvery row, on one page
18Papers indexed under sulfonyldimethane