Compound
prostaglandin E1
A potent vasodilator agent that increases peripheral blood flow.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C20H33O5
- Mass
- 353.479 g/mol
- Charge
- -1
- InChIKey
- GMVPRGQOIOIIMI-DWKJAMRDSA-M
- SMILES
- CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
11 entities
11 entities reached.
0 reported hops11 assembled from the scaffold
- PTGES3ProteinUNIPROT:Q15185substrate ofInferred only62 paths31 endpoints
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only56 paths13 endpoints
- CBR1ProteinUNIPROT:P16152substrate ofInferred only44 paths22 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only20 paths10 endpoints
- HPGDProteinUNIPROT:P15428substrate ofInferred only17 paths17 endpoints
- PTGESProteinUNIPROT:O14684substrate ofInferred only13 paths13 endpoints
- PTGES2ProteinUNIPROT:Q9H7Z7substrate ofInferred only11 paths11 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only9 paths2 endpoints
- CBR3ProteinUNIPROT:O75828substrate ofInferred only9 paths9 endpoints
- DHRS4ProteinUNIPROT:Q9BTZ2substrate ofInferred only7 paths7 endpoints
- SLCO3A1ProteinUNIPROT:Q9UIG8transported byInferred only6 paths3 endpoints
What the reference databases state
Statements
33 statements
33 statements · 2 reference databases · Subject: prostaglandin E1 · Sources: Human-GEM, Rhea
- prostaglandin E1 is converted to 15-oxoprostaglandin E1CompoundHuman-GEM MAR08546Inferred only
- prostaglandin E1 is converted to 15-oxoprostaglandin E1CompoundRhea RHEA:11636Inferred only
- prostaglandin E1 is converted to 15-oxoprostaglandin E1CompoundRhea RHEA:16477Inferred only
- 15-oxoprostaglandin E1 is converted to prostaglandin E1CompoundHuman-GEM MAR08546Inferred only
- prostaglandin E1 is converted to prostaglandin F1CompoundRhea RHEA:68612Inferred only
- prostaglandin E1 is converted to prostaglandin H1CompoundHuman-GEM MAR01394Inferred only
- prostaglandin E1 is converted to prostaglandin H1CompoundHuman-GEM MAR03985Inferred only
- prostaglandin H1 is converted to prostaglandin E1CompoundHuman-GEM MAR03985Inferred only
- prostaglandin H1 is converted to prostaglandin E1CompoundRhea RHEA:50436Inferred only
- prostaglandin E1 is converted to prostaglandin H1CompoundRhea RHEA:50436Inferred only
- prostaglandin H1 is converted to prostaglandin E1CompoundHuman-GEM MAR01394Inferred only
- prostaglandin E1 is a substrate of CBR1ProteinRhea RHEA:11636Inferred only
Show the remaining 21
- prostaglandin E1 is a substrate of CBR1ProteinHuman-GEM MAR08546Inferred only
- prostaglandin E1 is a substrate of CBR3ProteinHuman-GEM MAR08546Inferred only
- prostaglandin E1 is a substrate of DHRS1ProteinRhea RHEA:68612Inferred only
- prostaglandin E1 is a substrate of DHRS4ProteinHuman-GEM MAR08546Inferred only
- prostaglandin E1 is a substrate of HPGDProteinRhea RHEA:16477Inferred only
- prostaglandin E1 is a substrate of PTGESProteinHuman-GEM MAR01394Inferred only
- prostaglandin E1 is a substrate of PTGES2ProteinHuman-GEM MAR01394Inferred only
- prostaglandin E1 is a substrate of PTGES3ProteinHuman-GEM MAR01394Inferred only
- prostaglandin E1 is a substrate of PTGES3ProteinHuman-GEM MAR03985Inferred only
- prostaglandin E1 is a substrate of SCARF2ProteinHuman-GEM MAR01395Inferred only
- prostaglandin E1 is transported by ABCC4ProteinHuman-GEM MAR08934Inferred only
- prostaglandin E1 is transported by ABCC4ProteinRhea RHEA:66392Inferred only
- prostaglandin E1 is transported by SLCO1B1ProteinHuman-GEM MAR06190Inferred only
- prostaglandin E1 is transported by SLCO1B1ProteinHuman-GEM MAR06192Inferred only
- prostaglandin E1 is transported by SLCO1B1ProteinHuman-GEM MAR06191Inferred only
- prostaglandin E1 is transported by SLCO2A1ProteinHuman-GEM MAR08933Inferred only
- prostaglandin E1 is transported by SLCO2A1ProteinRhea RHEA:74395Inferred only
- prostaglandin E1 is transported by SLCO2A1ProteinHuman-GEM MAR06233Inferred only
- prostaglandin E1 is transported by SLCO2A1ProteinHuman-GEM MAR06268Inferred only
- prostaglandin E1 is transported by SLCO3A1ProteinHuman-GEM MAR06268Inferred only
- prostaglandin E1 is transported by SLCO3A1ProteinRhea RHEA:50980Inferred only
Reactions
21 reactions
prostaglandin E1prostaglandin H1
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3cytosol
Human-GEM MAR01394CC BY 4.0Reference data
water+MAM02776cprostaglandin E1
Catalysed by SCARF2
Reaction pageReversibleBalancedEC 4.2.1.-cytosol
Human-GEM MAR01395CC BY 4.0Reference data
prostaglandin H1prostaglandin E1
Catalysed by PTGES3
Reaction pageReversibleBalancedEC 5.3.99.3nucleus
Human-GEM MAR03985CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin E1MAM01980e+hydrogencarbonate+prostaglandin E1
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR06190CC BY 4.0Reference data
hydrogencarbonate+prostaglandin E1+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+prostaglandin E1+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06191CC BY 4.0Reference data
hydrogencarbonate+prostaglandin E1+MAM02901chydrogencarbonate+prostaglandin E1+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06192CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+prostaglandin E1CHEBI:16856+hydrogencarbonate+prostaglandin E1
Transported by SLCO2A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06233CC BY 4.0Reference data
prostaglandin E1prostaglandin E1
Transported by SLCO2A1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06268CC BY 4.0Reference data
15-oxoprostaglandin E1+proton+NADPH(4-)NADP(3-)+prostaglandin E1
Catalysed by DHRS4 or CBR1 or CBR3
Reaction pageReversibleBalancedEC 1.1.1.197cytosol
Human-GEM MAR08546CC BY 4.0Reference data
hydrogencarbonate+prostaglandin E1hydrogencarbonate+prostaglandin E1
Transported by SLCO2A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08933CC BY 4.0Reference data
ATP+water+prostaglandin E1ADP+proton+phosphate(3-)+prostaglandin E1
Transported by ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08934CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09396CC BY 4.0Reference data
Where it reaches
6 systems, 11 regions, 23 tissues, 26 transporter routes — routes, not measurements: transporters known to carry prostaglandin E1 are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: prostaglandin E1
- Also called
- PGE1
- Systematic name
- (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oate(13E,15S)-11α,15-dihydroxy-9-oxoprost-13-en-1-oate