Compound
all-trans-retinoic acid
An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute).
What it touches on the way
Mechanistic reach
36 entities
36 entities reached.
0 reported hops36 assembled from the scaffold
- CYP2C9ProteinUNIPROT:P11712metabolized byInferred only108 paths36 endpoints
- SLC16A1ProteinUNIPROT:P53985transported byInferred only100 paths25 endpoints
- CYP2C8ProteinUNIPROT:P10632metabolized byInferred only92 paths31 endpoints
- CYP3A4ProteinUNIPROT:P08684metabolized byInferred only90 paths45 endpoints
- CYP2E1ProteinUNIPROT:P05181metabolized byInferred only74 paths37 endpoints
- CYP1A2ProteinUNIPROT:P05177metabolized byInferred only64 paths32 endpoints
- CYP1B1ProteinUNIPROT:Q16678metabolized byInferred only47 paths24 endpoints
- CYP1A1ProteinUNIPROT:P04798metabolized byInferred only47 paths24 endpoints
- CYP2J2ProteinUNIPROT:P51589metabolized byInferred only45 paths15 endpoints
- CYP2A6ProteinUNIPROT:P11509metabolized byInferred only42 paths21 endpoints
- CYP2C19ProteinUNIPROT:P33261metabolized byInferred only40 paths20 endpoints
- CYP2B6ProteinUNIPROT:P20813metabolized byInferred only35 paths20 endpoints
Show the remaining 24
- CYP2D6ProteinUNIPROT:P10635metabolized byInferred only34 paths17 endpoints
- CYP26A1ProteinUNIPROT:O43174metabolized byInferred only30 paths15 endpoints
- ALDH1A1ProteinUNIPROT:P00352metabolized byInferred only28 paths28 endpoints
- CYP4F12ProteinUNIPROT:Q9HCS2metabolized byInferred only26 paths13 endpoints
- CYP4B1ProteinUNIPROT:P13584metabolized byInferred only24 paths14 endpoints
- CYP4F8ProteinUNIPROT:P98187metabolized byInferred only22 paths13 endpoints
- CYP2A13ProteinUNIPROT:Q16696metabolized byInferred only22 paths11 endpoints
- CYP3A5ProteinUNIPROT:P20815metabolized byInferred only22 paths11 endpoints
- UGT1A1ProteinUNIPROT:P22309metabolized byInferred only22 paths22 endpoints
- CYP2C18ProteinUNIPROT:P33260metabolized byInferred only22 paths11 endpoints
- CYP2A7ProteinUNIPROT:P20853metabolized byInferred only18 paths9 endpoints
- CYP2F1ProteinUNIPROT:P24903metabolized byInferred only18 paths9 endpoints
- SLC16A7ProteinUNIPROT:O60669transported byInferred only18 paths6 endpoints
- CYP3A43ProteinUNIPROT:Q9HB55metabolized byInferred only18 paths9 endpoints
- CYP3A7ProteinUNIPROT:P24462metabolized byInferred only16 paths8 endpoints
- CYP2U1ProteinUNIPROT:Q7Z449metabolized byInferred only15 paths15 endpoints
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only14 paths14 endpoints
- CYP4F11ProteinUNIPROT:Q9HBI6metabolized byInferred only14 paths7 endpoints
- SLC16A3ProteinUNIPROT:O15427transported byInferred only14 paths7 endpoints
- ALDH1A2ProteinUNIPROT:O94788metabolized byInferred only12 paths12 endpoints
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only11 paths11 endpoints
- CYP2S1ProteinUNIPROT:Q96SQ9metabolized byInferred only10 paths5 endpoints
- SLC16A8ProteinUNIPROT:O95907transported byInferred only5 paths1 endpoint
- CYP4Z1ProteinUNIPROT:Q86W10metabolized byInferred only4 paths2 endpoints
What the reference databases state
Statements
108 statements
108 statements · 1 reference database · Subject: all-trans-retinoic acid · Sources: Human-GEM
- 13-cis-retinal is converted to all-trans-retinoic acidCompoundHuman-GEM MAR06674Inferred only
- all-trans-retinoic acid is converted to 13-cis-retinalCompoundHuman-GEM MAR06674Inferred only
- all-trans-retinoic acid is converted to all-trans-18-hydroxyretinoateCompoundHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is converted to all-trans-18-hydroxyretinoateCompoundHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is converted to all-trans-4-hydroxyretinoateCompoundHuman-GEM MAR08700Inferred only
- all-trans-retinoic acid is converted to all-trans-4-hydroxyretinoateCompoundHuman-GEM MAR06701Inferred only
- all-trans-retinoic acid is converted to all-trans-4-hydroxyretinoateCompoundHuman-GEM MAR06700Inferred only
- all-trans-retinal is converted to all-trans-retinoic acidCompoundHuman-GEM MAR06646Inferred only
- all-trans-retinal is converted to all-trans-retinoic acidCompoundHuman-GEM MAR06647Inferred only
- all-trans-retinal is converted to all-trans-retinoic acidCompoundHuman-GEM MAR08698Inferred only
- all-trans-retinoic acid is converted to all-trans-retinalCompoundHuman-GEM MAR08698Inferred only
- all-trans-retinoic acid is converted to all-trans-retinoyl-1-O-(beta-D-glucuronate)CompoundHuman-GEM MAR08713Inferred only
Show the remaining 96
- retinal is converted to all-trans-retinoic acidCompoundHuman-GEM MAR20011Inferred only
- all-trans-retinoic acid is metabolised by ALDH1A1ProteinHuman-GEM MAR06674Inferred only
- all-trans-retinoic acid is metabolised by ALDH1A2ProteinHuman-GEM MAR06674Inferred only
- all-trans-retinoic acid is metabolised by CYP1A1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP1A1ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP1A2ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP1A2ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP1B1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP1B1ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP26A1ProteinHuman-GEM MAR06700Inferred only
- all-trans-retinoic acid is metabolised by CYP26A1ProteinHuman-GEM MAR06701Inferred only
- all-trans-retinoic acid is metabolised by CYP2A13ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2A13ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2A6ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2A6ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2A7ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2A7ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2B6ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2B6ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2C18ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2C18ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2C19ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2C19ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2C8ProteinHuman-GEM MAR08700Inferred only
- all-trans-retinoic acid is metabolised by CYP2C8ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2C8ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2C9ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2C9ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2C9ProteinHuman-GEM MAR08700Inferred only
- all-trans-retinoic acid is metabolised by CYP2D6ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2D6ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2E1ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2E1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2F1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2F1ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2J2ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2J2ProteinHuman-GEM MAR08700Inferred only
- all-trans-retinoic acid is metabolised by CYP2J2ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2S1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP2S1ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP2U1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP3A4ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP3A4ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP3A43ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP3A43ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP3A5ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP3A5ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP3A7ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP3A7ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP4B1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP4B1ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP4F11ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP4F11ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP4F12ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP4F12ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP4F8ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP4F8ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by CYP4Z1ProteinHuman-GEM MAR06658Inferred only
- all-trans-retinoic acid is metabolised by CYP4Z1ProteinHuman-GEM MAR06657Inferred only
- all-trans-retinoic acid is metabolised by UGT1A1ProteinHuman-GEM MAR08713Inferred only
- all-trans-retinoic acid is metabolised by UGT1A10ProteinHuman-GEM MAR08713Inferred only
- all-trans-retinoic acid is metabolised by UGT1A8ProteinHuman-GEM MAR08713Inferred only
- all-trans-retinoic acid is transported by SLC16A1ProteinHuman-GEM MAR06053Inferred only
- all-trans-retinoic acid is transported by SLC16A1ProteinHuman-GEM MAR06049Inferred only
- all-trans-retinoic acid is transported by SLC16A1ProteinHuman-GEM MAR06013Inferred only
- all-trans-retinoic acid is transported by SLC16A1ProteinHuman-GEM MAR06020Inferred only
- all-trans-retinoic acid is transported by SLC16A3ProteinHuman-GEM MAR06049Inferred only
- all-trans-retinoic acid is transported by SLC16A3ProteinHuman-GEM MAR06020Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06020Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06013Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06044Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06040Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06051Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06028Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06049Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06035Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06053Inferred only
- all-trans-retinoic acid is transported by SLC16A4ProteinHuman-GEM MAR06005Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06005Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06049Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06013Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06020Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06028Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06035Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06040Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06044Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06051Inferred only
- all-trans-retinoic acid is transported by SLC16A5ProteinHuman-GEM MAR06053Inferred only
- all-trans-retinoic acid is transported by SLC16A7ProteinHuman-GEM MAR06035Inferred only
- all-trans-retinoic acid is transported by SLC16A7ProteinHuman-GEM MAR06020Inferred only
- all-trans-retinoic acid is transported by SLC16A7ProteinHuman-GEM MAR06049Inferred only
- all-trans-retinoic acid is transported by SLC16A8ProteinHuman-GEM MAR06020Inferred only
- all-trans-retinoic acid is transported by SLC16A8ProteinHuman-GEM MAR06013Inferred only
- all-trans-retinoic acid is transported by SLC16A8ProteinHuman-GEM MAR06053Inferred only
- all-trans-retinoic acid is transported by SLC16A8ProteinHuman-GEM MAR06049Inferred only
- all-trans-retinoic acid is transported by SLC16A8ProteinHuman-GEM MAR06044Inferred only
Reactions
31 reactions
all-trans-retinoic acidall-trans-retinoic acid
Reaction pageReversibleBalancedEC 1.2.1.88cytosol, nucleus
Human-GEM MAR01686CC BY 4.0Reference data
acetoacetate+all-trans-retinoic acidacetoacetate+all-trans-retinoic acid
Transported by SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06005CC BY 4.0Reference data
2-hydroxybutyric acid+all-trans-retinoic acid2-hydroxybutyric acid+all-trans-retinoic acid
Transported by SLC16A8 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06013CC BY 4.0Reference data
pyruvate+all-trans-retinoic acidpyruvate+all-trans-retinoic acid
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06020CC BY 4.0Reference data
2-oxoglutarate(2-)+all-trans-retinoic acid2-oxoglutarate(2-)+all-trans-retinoic acid
Transported by SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06028CC BY 4.0Reference data
acetate+all-trans-retinoic acidacetate+all-trans-retinoic acid
Transported by SLC16A7 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06035CC BY 4.0Reference data
formic acid+all-trans-retinoic acidformic acid+all-trans-retinoic acid
Transported by SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06040CC BY 4.0Reference data
propionic acid+all-trans-retinoic acidpropionic acid+all-trans-retinoic acid
Transported by SLC16A8 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06044CC BY 4.0Reference data
(S)-lactic acid+all-trans-retinoic acid(S)-lactic acid+all-trans-retinoic acid
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06049CC BY 4.0Reference data
butyric acid+all-trans-retinoic acidbutyric acid+all-trans-retinoic acid
Transported by SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06051CC BY 4.0Reference data
(R)-3-hydroxybutyric acid+all-trans-retinoic acid(R)-3-hydroxybutyric acid+all-trans-retinoic acid
Transported by SLC16A8 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06053CC BY 4.0Reference data
water+NAD(+)+all-trans-retinal2proton+NADH(2-)+all-trans-retinoic acid
Catalysed by ALDH1A2 or ALDH1A1 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.36cytosol
Human-GEM MAR06646CC BY 4.0Reference data
Where it reaches
9 systems, 17 regions, 34 tissues, 34 transporter routes — routes, not measurements: transporters known to carry all-trans-retinoic acid are expressed there, and no source reports it arriving.
Loading the model…
Other names
36 names
Resolves to: all-trans-retinoic acid
- Also called
- (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid(all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2E,4E,6E,8E-tetraenoic acidAcide retinoique (French)AGN 100335all-(E)-retinoic acidall-trans retinoic acidall-trans-beta-Retinoic acidall-trans-tretinoinall-trans-vitamin A acidall-trans-vitamin A1 acidbeta-Retinoic acidretinoic acidRo 1-5488trans-retinoic acidTretin Mtretinoinvitamin A acid
- Systematic name
- (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
- Sold as
- AltrenoAtralinAvitaBetarretinBiacnaCordes vasDermairolRefissaRenovaRetin-ARetisol-AStieva-ATri-lumaVeltinVesanoid