Fat mass

Method

Adipose tissue mass by dual-energy X-ray absorptiometry, or by a method recorded on the edge where DXA was not used.

The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.

Notes

Kept separate from lean-mass rather than derived. A study reporting one and not the other is common, and inferring the other is a claim nobody made.

Findings

2 findings from 2 compounds, strongest first.

• resveratrol — decreases

  AWell establishedGrade A, Well established. Replicated human trial evidence, consistent direction.Finding

  “After resveratrol administration, a small but statistically significant reduction in body fat mass was discovered (ES: − 0.3 kg, 95% CI − 0.48 to − 0.12, p = 0.001) (Fig..”

  Study

  meta-analysis

  Participants

  1,375

  Dose

  200 to >1300 mg/day resveratrol across the constituent meta-analyses

  Population

  Pooled across 5 meta-analyses of RCTs of resveratrol supplementation vs non-resveratrol control; mixed clinical and non-clinical adult populations

  The effect of resveratrol supplementation on obesity indices: a critical umbrella review of interventional meta-analyses.2025PMID:41317227

• creatine — no detected effect on

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result

  “Collectively, in adults < 50 years of age, the combination of resistance exercise and creatine supplementation produces a very small reduction in body fat percentage without a corresponding decrease in absolute fat mass.”

  Study

  meta-analysis

  Population

  adults <50 years of age performing resistance exercise

  Resistance Exercise and Creatine Supplementation on Fat Mass in Adults < 50 Years of Age: A Systematic Review and Meta-Analysis.2023PMID:37892421An author is affiliated with a producer