Compound

3,4-dihydroxyphenylacetate

A dihydroxy monocarboxylic acid anion that is the conjugate base of (3,4-dihydroxyphenyl)acetic acid, arising from deprotonation of the carboxy group.

Definition from ChEBI (CHEBI:17612), read 2026-09-23. CC BY 4.0.

CHEBI:17612ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of 3,4-dihydroxyphenylacetate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C8H7O4
Mass: 167.14 g/mol
Charge: -1
InChIKey: CFFZDZCDUFSOFZ-UHFFFAOYSA-M
SMILES: O=C([O-])Cc1ccc(O)c(O)c1
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

What the reference databases state

Statements

9 statements

9 statements · 2 reference databases · Subject: 3,4-dihydroxyphenylacetate · Sources: Human-GEM, Rhea

Order

3,4-dihydroxyphenylacetate is converted to 3,4-dihydroxyphenylacetaldehydeCompoundRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundHuman-GEM MAR06760Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundHuman-GEM MAR06761Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetate is metabolised by ALDH9A1ProteinRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetate is metabolised by COMTProteinHuman-GEM MAR06762Inferred only
3,4-dihydroxyphenylacetate is a substrate of LRTOMTProteinHuman-GEM MAR06762Inferred only
3,4-dihydroxyphenylacetate is transported by SLC22A6ProteinHuman-GEM MAR11812Inferred only
3,4-dihydroxyphenylacetate is transported by SLC22A8ProteinHuman-GEM MAR11812Inferred only

Reactions

14 reactions

3,4-dihydroxyphenylacetaldehyde+water+NAD(+)3,4-dihydroxyphenylacetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06760CC BY 4.0Reference data
3,4-dihydroxyphenylacetaldehyde+water+NADP(3-)3,4-dihydroxyphenylacetate+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06761CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+S-adenosyl-L-methionineproton+MAM02137c+CHEBI:16680
Catalysed by COMT or LRTOMT
Reaction pageLeft to rightBalancedEC 2.1.1.6cytosol
Human-GEM MAR06762CC BY 4.0Reference data
3,4-dihydroxyphenylacetate
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11432CC BY 4.0Reference data
3,4-dihydroxyphenylacetate3,4-dihydroxyphenylacetate
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11812CC BY 4.0Reference data
CHEBI:16237+NADH(2-)+dioxygen3,4-dihydroxyphenylacetate+chloride+NAD(1-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:14689CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+dioxygenCHEBI:58030+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:15633CC BY 4.0Reference data
CHEBI:48999+FADH2(2-)+dioxygen3,4-dihydroxyphenylacetate+FAD(3-)+water+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:30595CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+NADH(2-)+dioxygen+hydronCHEBI:138056+NAD(1-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:54088CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+NADPH(4-)+dioxygen+hydronCHEBI:138056+NADP(3-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:54092CC BY 4.0Reference data
CHEBI:48999+FMNH2+dioxygen3,4-dihydroxyphenylacetate+FMN+water+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:59880CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+hydronCHEBI:17254+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:62556CC BY 4.0Reference data

Show the remaining 2

Where it reaches

1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry 3,4-dihydroxyphenylacetate are expressed there, and no source reports it arriving.

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Nervous

Other names

2 names

Resolves to: 3,4-dihydroxyphenylacetate

Also called: homoprotocatechuate
Systematic name: (3,4-dihydroxyphenyl)acetate

Compound

3,4-dihydroxyphenylacetate

A dihydroxy monocarboxylic acid anion that is the conjugate base of (3,4-dihydroxyphenyl)acetic acid, arising from deprotonation of the carboxy group.

Definition from ChEBI (CHEBI:17612), read 2026-09-23. CC BY 4.0.

CHEBI:17612ChEBI

Open in the graph

Structure

2D depiction · 3D model shown

Loading the model…

A generated conformer of 3,4-dihydroxyphenylacetate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C8H7O4
Mass: 167.14 g/mol
Charge: -1
InChIKey: CFFZDZCDUFSOFZ-UHFFFAOYSA-M
SMILES: O=C([O-])Cc1ccc(O)c(O)c1
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

What the reference databases state

Statements

9 statements

9 statements · 2 reference databases · Subject: 3,4-dihydroxyphenylacetate · Sources: Human-GEM, Rhea

Order

3,4-dihydroxyphenylacetate is converted to 3,4-dihydroxyphenylacetaldehydeCompoundRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundHuman-GEM MAR06760Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundHuman-GEM MAR06761Inferred only
3,4-dihydroxyphenylacetaldehyde is converted to 3,4-dihydroxyphenylacetateCompoundRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetate is metabolised by ALDH9A1ProteinRhea RHEA:69080Inferred only
3,4-dihydroxyphenylacetate is metabolised by COMTProteinHuman-GEM MAR06762Inferred only
3,4-dihydroxyphenylacetate is a substrate of LRTOMTProteinHuman-GEM MAR06762Inferred only
3,4-dihydroxyphenylacetate is transported by SLC22A6ProteinHuman-GEM MAR11812Inferred only
3,4-dihydroxyphenylacetate is transported by SLC22A8ProteinHuman-GEM MAR11812Inferred only

Reactions

14 reactions

3,4-dihydroxyphenylacetaldehyde+water+NAD(+)3,4-dihydroxyphenylacetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06760CC BY 4.0Reference data
3,4-dihydroxyphenylacetaldehyde+water+NADP(3-)3,4-dihydroxyphenylacetate+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR06761CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+S-adenosyl-L-methionineproton+MAM02137c+CHEBI:16680
Catalysed by COMT or LRTOMT
Reaction pageLeft to rightBalancedEC 2.1.1.6cytosol
Human-GEM MAR06762CC BY 4.0Reference data
3,4-dihydroxyphenylacetate
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11432CC BY 4.0Reference data
3,4-dihydroxyphenylacetate3,4-dihydroxyphenylacetate
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11812CC BY 4.0Reference data
CHEBI:16237+NADH(2-)+dioxygen3,4-dihydroxyphenylacetate+chloride+NAD(1-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:14689CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+dioxygenCHEBI:58030+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:15633CC BY 4.0Reference data
CHEBI:48999+FADH2(2-)+dioxygen3,4-dihydroxyphenylacetate+FAD(3-)+water+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:30595CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+NADH(2-)+dioxygen+hydronCHEBI:138056+NAD(1-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:54088CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+NADPH(4-)+dioxygen+hydronCHEBI:138056+NADP(3-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:54092CC BY 4.0Reference data
CHEBI:48999+FMNH2+dioxygen3,4-dihydroxyphenylacetate+FMN+water+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:59880CC BY 4.0Reference data
3,4-dihydroxyphenylacetate+hydronCHEBI:17254+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:62556CC BY 4.0Reference data

Show the remaining 2

Where it reaches

1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry 3,4-dihydroxyphenylacetate are expressed there, and no source reports it arriving.

Loading the model…

Nervous

Other names

2 names

Resolves to: 3,4-dihydroxyphenylacetate

Also called: homoprotocatechuate
Systematic name: (3,4-dihydroxyphenyl)acetate