Compound
isocitric acid
A tricarboxylic acid that is propan-1-ol with a hydrogen at each of the 3 carbon positions replaced by a carboxy group.
Definition from ChEBI (CHEBI:30887), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- SLC25A1ProteinUNIPROT:P53007transported byInferred only280 paths28 endpoints
- IDH1ProteinUNIPROT:O75874substrate ofInferred only60 paths30 endpoints
- HIF1AProteinUNIPROT:Q16665transported byInferred only49 paths48 endpoints
- ACO2ProteinUNIPROT:Q99798substrate ofInferred only20 paths20 endpoints
- IDH2ProteinUNIPROT:P48735substrate ofInferred only17 paths17 endpoints
- ACO1ProteinUNIPROT:P21399substrate ofInferred only16 paths16 endpoints
- IDH3AProteinUNIPROT:P50213substrate ofInferred only15 paths15 endpoints
- IDH3BProteinUNIPROT:O43837substrate ofInferred only6 paths6 endpoints
- IDH3GProteinUNIPROT:P51553substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
23 statements
23 statements · 1 reference database · Subject: isocitric acid · Sources: Human-GEM
- cis-aconitic acid is converted to isocitric acidCompoundHuman-GEM MAR04589Inferred only
- isocitric acid is converted to cis-aconitic acidCompoundHuman-GEM MAR04589Inferred only
- citric acid is converted to isocitric acidCompoundHuman-GEM MAR04454Inferred only
- isocitric acid is converted to citric acidCompoundHuman-GEM MAR04454Inferred only
- isocitric acid is a substrate of ACO1ProteinHuman-GEM MAR04454Inferred only
- isocitric acid is a substrate of ACO2ProteinHuman-GEM MAR04589Inferred only
- isocitric acid is a substrate of IDH1ProteinHuman-GEM MAR00710Inferred only
- isocitric acid is a substrate of IDH1ProteinHuman-GEM MAR00712Inferred only
- isocitric acid is a substrate of IDH2ProteinHuman-GEM MAR03958Inferred only
- isocitric acid is a substrate of IDH3AProteinHuman-GEM MAR03957Inferred only
- isocitric acid is a substrate of IDH3BProteinHuman-GEM MAR03957Inferred only
- isocitric acid is a substrate of IDH3GProteinHuman-GEM MAR03957Inferred only
Show the remaining 11
- isocitric acid is transported by HIF1AProteinHuman-GEM MAR00713Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR06297Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR02216Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR02303Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR02413Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR02414Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR06292Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR04972Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR06277Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR06290Inferred only
- isocitric acid is transported by SLC25A1ProteinHuman-GEM MAR06291Inferred only
Reactions
22 reactions
isocitric acid+NADP(3-)2-oxoglutarate(2-)+carbon dioxide+NADPH(4-)
Catalysed by IDH1
Reaction pageReversibleBalancedEC 1.1.1.42GO:0005829
Human-GEM MAR00710CC BY 4.0Reference data
isocitric acid+NADP(3-)2-oxoglutarate(2-)+carbon dioxide+NADPH(4-)
Catalysed by IDH1
Reaction pageReversibleBalancedEC 1.1.1.42GO:0005777
Human-GEM MAR00712CC BY 4.0Reference data
2-oxoglutarate(2-)+isocitric acid2-oxoglutarate(2-)+isocitric acid
Transported by HIF1A
Reaction pageLeft to rightBalancedGO:0005829, GO:0005777
Human-GEM MAR00713CC BY 4.0Reference data
isocitric acid+(S)-malateisocitric acid+(S)-malate
Transported by SLC25A1
Reaction pageReversibleBalancedGO:0005759, GO:0005829
Human-GEM MAR02216CC BY 4.0Reference data
2-oxoglutarate(2-)+isocitric acid2-oxoglutarate(2-)+isocitric acid
Transported by SLC25A1
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR02303CC BY 4.0Reference data
isocitric acid+succinate(2-)isocitric acid+succinate(2-)
Transported by SLC25A1
Reaction pageReversibleBalancedGO:0005759, GO:0005829
Human-GEM MAR02413CC BY 4.0Reference data
isocitric acid+oxalic acidisocitric acid+oxalic acid
Transported by SLC25A1
Reaction pageReversibleBalancedGO:0005759, GO:0005829
Human-GEM MAR02414CC BY 4.0Reference data
isocitric acid+NAD(+)2-oxoglutarate(2-)+carbon dioxide+NADH(2-)
Catalysed by IDH3B & IDH3A & IDH3G
Reaction pageLeft to rightBalancedEC 1.1.1.41GO:0005759
Human-GEM MAR03957CC BY 4.0Reference data
isocitric acid+NADP(3-)2-oxoglutarate(2-)+carbon dioxide+NADPH(4-)
Catalysed by IDH2
Reaction pageReversibleBalancedEC 1.1.1.42GO:0005759
Human-GEM MAR03958CC BY 4.0Reference data
Catalysed by ACO1
Reaction pageReversibleBalancedEC 4.2.1.3GO:0005829
Human-GEM MAR04454CC BY 4.0Reference data
cis-aconitic acid+waterisocitric acid
Catalysed by ACO2
Reaction pageReversibleBalancedEC 4.2.1.3GO:0005759
Human-GEM MAR04589CC BY 4.0Reference data
citric acid+isocitric acidcitric acid+isocitric acid
Transported by SLC25A1
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR04972CC BY 4.0Reference data
Where it reaches
7 systems, 11 regions, 24 tissues, 24 transporter routes — routes, not measurements: transporters known to carry isocitric acid are expressed there, and no source reports it arriving.
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Other names
3 names
Resolves to: isocitric acid
- Also called
- 1-Hydroxypropane-1,2,3-tricarboxylic acid1-Hydroxytricarballylic acid
- Systematic name
- 3-carboxy-2,3-dideoxypentaric acid