Endpoint
Pittsburgh Sleep Quality Index global score
CAT:outcome/psqi-global-scorereported in score (0-21)4 findings from 4 compounds
What moved it
How to read these marks4 findings · 4 compounds · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| crocin-1 | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| melatonin | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| trazodone | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| NMN zwitterion | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
3 findings
crocin-1 — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After 8-week intervention, crocin significantly decreased Beck Depression Inventory (b - 6.66; 95% CI, - 9.88, - 3.45; P < 0.0001), Beck Anxiety Inventory (b - 4.35; 95% CI, - 5.94, - 2.75; P < 0.0001), general health questionnaire (b - 4.45; 95% CI, - 7.68, - 1.22; P = 0.008) and Pittsburgh Sleep Quality Index (b - 2.73; 95% CI, - 3.74, - 1.73; P < 0.0001) in patients under MMT, compared with the placebo.”
Quoted verbatim from The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial.. - Study
- RCT
- Duration
- 8 weeks
- Dose
- 30 mg/day crocin (15 mg twice daily)
- Population
- Patients under methadone maintenance treatment (methadone in both arms); crocin 30 mg/day versus placebo
The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial.2019PMID:30795785Permalink
melatonin — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After treatment, the study group showed significantly decreased scores in HAMD, HAMA, and PSQI scales in contrast to the other.”
Quoted verbatim from Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.. - Study
- RCT
- Dose
- 3 mg in the evening, 3 cycles of 4 weeks treatment with 1 week withdrawal
- Population
- Healthy perimenopausal Chinese women aged 45-55 years; melatonin 3 mg versus placebo capsules
Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.2023PMID:37854169Permalink
NMN zwitterion — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“The NMN group had improved sleep quality at 12 weeks relative to the placebo group as evidenced by lower scores for "Daytime dysfunction" and "Global PSQI" on the Pittsburgh Sleep Questionnaire.”
Quoted verbatim from Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study.. - Study
- RCT
- Duration
- 3 months
- Dose
- 250 mg/day NMN for 12 weeks
- Population
- Older adults in a randomized, placebo-controlled, double-blind, parallel-group trial; NMN group versus placebo group at 12 weeks
Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study.2024PMID:38789831Permalink
Measured, no effect detected
1 finding
trazodone — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“For example, between baseline and 1-month, mean PSQI scores decreased 2.9 and 3.9 points among those randomized to placebo and trazodone, respectively; the difference in mean change was not significant (p =.145).”
Quoted verbatim from Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 50 mg capsules, 1-3 at bedtime as needed, 50-150 mg
- Population
- Methadone-maintained adults with sleep complaints (baseline PSQI of 6 or higher); trazodone 50 mg capsules self-titrated at bedtime to 50-150 mg, against identical placebo capsules, for one month; all received a sleep hygiene brochure
Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.2012PMID:21798674Permalink
How it is measured
Global score of the Pittsburgh Sleep Quality Index, a 19-item self-report questionnaire covering the past month, summed from seven component domains to a range of 0 to 21.
Measured, not recorded
- Subject
- pittsburgh sleep quality index global score
- Measurements
- 4 measurements
- Recorded as a finding
- No
Show what was measured
Pittsburgh Sleep Quality Index global score
no effect, p = 0.312, n = 50
PSQI | 0 | 8.0 (3.0) | 7.0 (3.0) | 0.312 | < 0.001 | < 0.001 | 0.083
PMID:42770942 · one of two readings recorded this
Pittsburgh Sleep Quality Index global score
decreases, p = 0.031, n = 50
3 | 6.0 (4.0) | 7.0 (2.0) | 0.031
PMID:42770942 · one of two readings recorded this
Pittsburgh Sleep Quality Index global score
decreases, p = 0.001, n = 50
6 | 5.0 (3.0) | 8.0 (3.0) | < 0.001
PMID:42770942 · one of two readings recorded this
Pittsburgh Sleep Quality Index global score
no effect, p = 0.89, n = 50
8 | 7.0 (3.0) | 7.0 (2.0) | 0.890
PMID:42770942 · one of two readings recorded this
Sources cited
4 papers
- Subject
- pittsburgh sleep quality index global score
- Findings
- 4
- Papers
- 4
Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study.record2024PMID:387898311 finding
Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.record2023PMID:378541691 finding
The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial.record2019PMID:307957851 finding
Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.record2012PMID:217986741 finding