What it touches on the way
Mechanistic reach
21 entities
21 entities reached.
0 reported hops21 assembled from the scaffold
- CPProteinUNIPROT:P00450transported byInferred only44 paths22 endpoints
- UGT1A1ProteinUNIPROT:P22309metabolized byInferred only25 paths25 endpoints
- UGT1A9ProteinUNIPROT:O60656metabolized byInferred only24 paths24 endpoints
- UGT1A4ProteinUNIPROT:P22310metabolized byInferred only23 paths23 endpoints
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only22 paths11 endpoints
- UGT1A6ProteinUNIPROT:P19224metabolized byInferred only18 paths18 endpoints
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only16 paths16 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only15 paths15 endpoints
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only14 paths14 endpoints
- UGT1A7ProteinUNIPROT:Q9HAW7metabolized byInferred only12 paths12 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only12 paths2 endpoints
- UGT2B4ProteinUNIPROT:P06133metabolized byInferred only11 paths11 endpoints
Show the remaining 9
- UGT2B15ProteinUNIPROT:P54855metabolized byInferred only10 paths10 endpoints
- UGT2B17ProteinUNIPROT:O75795metabolized byInferred only9 paths9 endpoints
- UGT2B11ProteinUNIPROT:O75310metabolized byInferred only8 paths8 endpoints
- UGT2A1ProteinUNIPROT:P0DTE4metabolized byInferred only8 paths8 endpoints
- UGT1A5ProteinUNIPROT:P35504metabolized byInferred only8 paths8 endpoints
- UGT2A3ProteinUNIPROT:Q6UWM9metabolized byInferred only8 paths8 endpoints
- UGT2B28ProteinUNIPROT:Q9BY64metabolized byInferred only8 paths8 endpoints
- UGT2B10ProteinUNIPROT:P36537metabolized byInferred only7 paths7 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only3 paths2 endpoints
What the reference databases state
Statements
34 statements
34 statements · 1 reference database · Subject: bilirubin IXalpha · Sources: Human-GEM
- biliverdin IXalpha is converted to bilirubin IXalphaCompoundHuman-GEM MAR04764Inferred only
- biliverdin IXalpha is converted to bilirubin IXalphaCompoundHuman-GEM MAR08634Inferred only
- bilirubin IXalpha is metabolised by UGT1A1ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A10ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A3ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A4ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A5ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A6ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A7ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A8ProteinHuman-GEM MAR01820Inferred only
- bilirubin IXalpha is metabolised by UGT1A8ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT1A9ProteinHuman-GEM MAR04766Inferred only
Show the remaining 22
- bilirubin IXalpha is metabolised by UGT2A1ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2A3ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2B10ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2B11ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2B15ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2B17ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2B28ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2B4ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT2B7ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT3A1ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is metabolised by UGT3A2ProteinHuman-GEM MAR04766Inferred only
- bilirubin IXalpha is transported by CPProteinHuman-GEM MAR05004Inferred only
- bilirubin IXalpha is transported by CPProteinHuman-GEM MAR05005Inferred only
- bilirubin IXalpha is transported by SLCO1A2ProteinHuman-GEM MAR06110Inferred only
- bilirubin IXalpha is transported by SLCO1A2ProteinHuman-GEM MAR06108Inferred only
- bilirubin IXalpha is transported by SLCO1A2ProteinHuman-GEM MAR06109Inferred only
- bilirubin IXalpha is transported by SLCO1A2ProteinHuman-GEM MAR06095Inferred only
- bilirubin IXalpha is transported by SLCO1B1ProteinHuman-GEM MAR08635Inferred only
- bilirubin IXalpha is transported by SLCO1B3ProteinHuman-GEM MAR06108Inferred only
- bilirubin IXalpha is transported by SLCO1B3ProteinHuman-GEM MAR06109Inferred only
- bilirubin IXalpha is transported by SLCO1B3ProteinHuman-GEM MAR06110Inferred only
- bilirubin IXalpha is transported by SLCO1B3ProteinHuman-GEM MAR06095Inferred only
Reactions
16 reactions
bilirubin IXalpha+UDP-alpha-D-glucuronateMAM01398r+UDP
Catalysed by UGT1A8
Reaction pageReversibleBalancedEC 2.4.1.17GO:0005783
Human-GEM MAR01820CC BY 4.0Reference data
biliverdin IXalpha+proton+NADH(2-)bilirubin IXalpha+NAD(+)
Reaction pageLeft to rightBalancedEC 1.3.1.24GO:0005829
Human-GEM MAR04764CC BY 4.0Reference data
bilirubin IXalphabilirubin IXalpha
Reaction pageReversibleBalancedGO:0005829, GO:0005783
Human-GEM MAR04765CC BY 4.0Reference data
bilirubin IXalpha+2UDP-alpha-D-glucuronateMAM01397r+2UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17GO:0005783
Human-GEM MAR04766CC BY 4.0Reference data
bilirubin IXalpha+MAM01397r2MAM01398r
Reaction pageLeft to rightBalancedGO:0005783
Human-GEM MAR04767CC BY 4.0Reference data
bilirubin IXalpha+sodium(1+)bilirubin IXalpha+sodium(1+)
Transported by CP
Reaction pageReversibleBalancedGO:0005829, GO:0005783
Human-GEM MAR05004CC BY 4.0Reference data
bilirubin IXalpha+sodium(1+)bilirubin IXalpha+sodium(1+)
Transported by CP
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR05005CC BY 4.0Reference data
bilirubin IXalphabilirubin IXalpha
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR05440CC BY 4.0Reference data
bilirubin IXalpha+CHEBI:16856+hydrogencarbonatebilirubin IXalpha+CHEBI:16856+hydrogencarbonate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005615, GO:0005829
Human-GEM MAR06095CC BY 4.0Reference data
bilirubin IXalpha+MAM01980c+hydrogencarbonatebilirubin IXalpha+MAM01980e+hydrogencarbonate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalance undeterminableGO:0005615, GO:0005829
Human-GEM MAR06108CC BY 4.0Reference data
bilirubin IXalpha+hydrogencarbonate+2,4-dinitrophenyl-S-glutathionebilirubin IXalpha+hydrogencarbonate+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005615, GO:0005829
Human-GEM MAR06109CC BY 4.0Reference data
bilirubin IXalpha+hydrogencarbonate+MAM02901cbilirubin IXalpha+hydrogencarbonate+MAM02901e
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005615, GO:0005829
Human-GEM MAR06110CC BY 4.0Reference data
Where it reaches
4 systems, 4 regions, 13 tissues, 17 transporter routes — routes, not measurements: transporters known to carry bilirubin IXalpha are expressed there, and no source reports it arriving.
Loading the model…
Other names
9 names
Resolves to: bilirubin IXalpha
- Also called
- 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dionebilirubin-IXalphabilirubin-IXαbilirubin(Z,Z)
- Systematic name
- 3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acidbilirubin