Compound
hyocholate
A bile acid anion that is the conjugate base of hyocholic acid, obtained bye deprotonation of the carboxy group; major species at pH 7.3.
Definition from ChEBI (CHEBI:133661), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, anion
- Formula
- C24H39O5
- Mass
- 407.571 g/mol
- Charge
- -1
- InChIKey
- DKPMWHFRUGMUKF-KWXDGCAGSA-M
- SMILES
- [H][C@@]12CC[C@]([H])([C@H](C)CCC(=O)[O-])[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])[C@@H](O)[C@@H](O)[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
15 entities
15 entities reached.
0 reported hops15 assembled from the scaffold
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only80 paths16 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only66 paths30 endpoints
- UGT2A1ProteinUNIPROT:P0DTE4metabolized byInferred only24 paths8 endpoints
- UGT2B4ProteinUNIPROT:P06133metabolized byInferred only22 paths11 endpoints
- UGT2A3ProteinUNIPROT:Q6UWM9metabolized byInferred only16 paths8 endpoints
- ABCC2ProteinUNIPROT:Q92887transported byInferred only15 paths15 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only15 paths15 endpoints
- UGT2A2ProteinUNIPROT:P0DTE5metabolized byInferred only9 paths9 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only9 paths9 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only8 paths3 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only5 paths5 endpoints
- SLC10A1ProteinUNIPROT:Q14973transported byInferred only4 paths2 endpoints
What the reference databases state
Statements
29 statements
29 statements · 2 reference databases · Subject: hyocholate · Sources: Human-GEM, Rhea
- chenodeoxycholate is converted to hyocholateCompoundHuman-GEM MAR12183Inferred only
- hyocholate is converted to hyocholate 6-O-(beta-D-glucuronate)CompoundRhea RHEA:52968Inferred only
- hyocholate is converted to hyocholoyl-24-O-(beta-D-glucuronate)CompoundRhea RHEA:52960Inferred only
- hyocholate is metabolised by UGT1A3ProteinRhea RHEA:52960Inferred only
- hyocholate is metabolised by UGT2A1ProteinHuman-GEM MAR12246Inferred only
- hyocholate is metabolised by UGT2A1ProteinHuman-GEM MAR12247Inferred only
- hyocholate is metabolised by UGT2A1ProteinRhea RHEA:52960Inferred only
- hyocholate is metabolised by UGT2A2ProteinRhea RHEA:52960Inferred only
- hyocholate is metabolised by UGT2A3ProteinHuman-GEM MAR12246Inferred only
- hyocholate is metabolised by UGT2A3ProteinHuman-GEM MAR12247Inferred only
- hyocholate is metabolised by UGT2B4ProteinHuman-GEM MAR12251Inferred only
- hyocholate is metabolised by UGT2B4ProteinHuman-GEM MAR12250Inferred only
Show the remaining 17
- hyocholate is metabolised by UGT2B7ProteinHuman-GEM MAR12246Inferred only
- hyocholate is metabolised by UGT2B7ProteinHuman-GEM MAR12251Inferred only
- hyocholate is metabolised by UGT2B7ProteinHuman-GEM MAR12250Inferred only
- hyocholate is metabolised by UGT2B7ProteinHuman-GEM MAR12247Inferred only
- hyocholate is metabolised by UGT2B7ProteinRhea RHEA:52968Inferred only
- hyocholate is transported by ABCB11ProteinHuman-GEM MAR10103Inferred only
- hyocholate is transported by ABCB11ProteinHuman-GEM MAR12262Inferred only
- hyocholate is transported by ABCC2ProteinHuman-GEM MAR12262Inferred only
- hyocholate is transported by ABCC3ProteinHuman-GEM MAR10103Inferred only
- hyocholate is transported by ABCC3ProteinHuman-GEM MAR12262Inferred only
- hyocholate is transported by SLC10A1ProteinHuman-GEM MAR10119Inferred only
- hyocholate is transported by SLC10A1ProteinHuman-GEM MAR12264Inferred only
- hyocholate is transported by SLC10A2ProteinHuman-GEM MAR12264Inferred only
- hyocholate is transported by SLC51AProteinHuman-GEM MAR12263Inferred only
- hyocholate is transported by SLC51BProteinHuman-GEM MAR12263Inferred only
- hyocholate is transported by SLCO1B1ProteinHuman-GEM MAR12263Inferred only
- hyocholate is transported by SLCO1B3ProteinHuman-GEM MAR12263Inferred only
Reactions
17 reactions
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10087CC BY 4.0Reference data
ATP+water+hyocholateADP+proton+phosphate(3-)+hyocholate
Transported by ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10103CC BY 4.0Reference data
ATP+CHEBI:1146900+hyocholateAMP+diphosphate(3-)+MAM10038c
Reaction pageLeft to rightBalancedEC 6.2.1.7cytosol
Human-GEM MAR10105CC BY 4.0Reference data
water+MAM10038cCHEBI:1146900+proton+hyocholate
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR10106CC BY 4.0Reference data
2sodium(1+)+hyocholate2sodium(1+)+hyocholate
Transported by SLC10A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR10119CC BY 4.0Reference data
chenodeoxycholate+proton+NADPH(4-)+dioxygenwater+NADP(3-)+hyocholate
Catalysed by CYP3A4
Reaction pageLeft to rightBalancedEC 1.14.14.57cytosol
Human-GEM MAR12183CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR12221CC BY 4.0Reference data
UDP-alpha-D-glucuronate+hyocholateUDP+MAM03642c
Catalysed by UGT2A3 or UGT2B7 or UGT2A1
Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol
Human-GEM MAR12246CC BY 4.0Reference data
UDP-alpha-D-glucuronate+hyocholateUDP+MAM03642r
Catalysed by UGT2A3 or UGT2B7 or UGT2A1
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR12247CC BY 4.0Reference data
UDP-alpha-D-glucuronate+hyocholateUDP+MAM03643c
Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol
Human-GEM MAR12250CC BY 4.0Reference data
UDP-alpha-D-glucuronate+hyocholateUDP+MAM03643r
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR12251CC BY 4.0Reference data
ATP+water+hyocholateADP+proton+phosphate(3-)+hyocholate
Transported by ABCC2 or ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR12262CC BY 4.0Reference data
Where it reaches
7 systems, 15 regions, 33 tissues, 58 transporter routes — routes, not measurements: transporters known to carry hyocholate are expressed there, and no source reports it arriving.
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Other names
9 names
Resolves to: hyocholate
- Also called
- (3alpha,5beta,6alpha,7alpha)-3,6,7-trihydroxycholan-24-oate(3α,5β,6α,7α)-3,6,7-trihydroxycholan-24-oatealpha-hyocholategamma-muricholatehyocholic acidα-hyocholateγ-muricholate
- Systematic name
- 3alpha,6alpha,7alpha-trihydroxy-5beta-cholan-24-oate3α,6α,7α-trihydroxy-5β-cholan-24-oate