Compound
CHEBI:17895
A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin.
What it touches on the way
Mechanistic reach
24 entities
24 entities reached.
0 reported hops24 assembled from the scaffold
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only176 paths8 endpoints
- GOT2ProteinUNIPROT:P00505substrate ofInferred only68 paths34 endpoints
- SLC7A9ProteinUNIPROT:P82251transported byInferred only45 paths9 endpoints
- THProteinUNIPROT:P07101substrate ofInferred only44 paths22 endpoints
- SLC7A6ProteinUNIPROT:Q92536transported byInferred only36 paths2 endpoints
- TYRProteinUNIPROT:P14679substrate ofInferred only33 paths11 endpoints
- SLC43A1ProteinUNIPROT:O75387transported byInferred only33 paths33 endpoints
- TPOProteinUNIPROT:P07202substrate ofInferred only28 paths14 endpoints
- GOT1ProteinUNIPROT:P17174substrate ofInferred only24 paths24 endpoints
- DDCProteinUNIPROT:P20711substrate ofInferred only19 paths19 endpoints
- SLC7A8ProteinUNIPROT:Q9UHI5transported byInferred only18 paths18 endpoints
- SLC7A7ProteinUNIPROT:Q9UM01transported byInferred only16 paths16 endpoints
Show the remaining 12
- TATProteinUNIPROT:P17735substrate ofInferred only14 paths7 endpoints
- SLC3A2ProteinUNIPROT:P08195transported byInferred only12 paths12 endpoints
- BRPF1ProteinUNIPROT:P55201substrate ofInferred only9 paths9 endpoints
- SLC6A19ProteinUNIPROT:Q695T7transported byInferred only7 paths6 endpoints
- YARS1ProteinUNIPROT:P54577substrate ofInferred only7 paths7 endpoints
- IL4I1ProteinUNIPROT:Q96RQ9substrate ofInferred only6 paths6 endpoints
- SLC3A1ProteinUNIPROT:Q07837transported byInferred only5 paths1 endpoint
- TTLProteinUNIPROT:Q8NG68substrate ofInferred only4 paths4 endpoints
- SLC36A1ProteinUNIPROT:Q7Z2H8transported byInferred only2 paths2 endpoints
- SLC6A14ProteinUNIPROT:Q9UN76transported byInferred only2 paths2 endpoints
- CLTRNProteinUNIPROT:Q9HBJ8transported byInferred only1 path1 endpoint
- OCA2ProteinUNIPROT:Q04671transported byInferred only1 path1 endpoint
What the reference databases state
Statements
84 statements
84 statements · 1 reference database · Subject: CHEBI:17895 · Sources: Human-GEM
- CHEBI:17895 is converted to 3-(4-hydroxyphenyl)pyruvateCompoundHuman-GEM MAR06780Inferred only
- CHEBI:17895 is converted to 3-(4-hydroxyphenyl)pyruvateCompoundHuman-GEM MAR06770Inferred only
- CHEBI:17895 is converted to 3-(4-hydroxyphenyl)pyruvateCompoundHuman-GEM MAR06768Inferred only
- CHEBI:17895 is converted to CHEBI:15765CompoundHuman-GEM MAR08541Inferred only
- CHEBI:17895 is converted to CHEBI:15765CompoundHuman-GEM MAR06729Inferred only
- CHEBI:17895 is converted to L-dopaquinoneCompoundHuman-GEM MAR06874Inferred only
- CHEBI:17895 is a substrate of BRPF1ProteinHuman-GEM MAR09505Inferred only
- CHEBI:17895 is a substrate of DDCProteinHuman-GEM MAR06787Inferred only
- CHEBI:17895 is a substrate of GOT1ProteinHuman-GEM MAR06768Inferred only
- CHEBI:17895 is a substrate of GOT2ProteinHuman-GEM MAR06768Inferred only
- CHEBI:17895 is a substrate of GOT2ProteinHuman-GEM MAR06780Inferred only
- CHEBI:17895 is a substrate of IL4I1ProteinHuman-GEM MAR06770Inferred only
Show the remaining 72
- CHEBI:17895 is a substrate of TATProteinHuman-GEM MAR06768Inferred only
- CHEBI:17895 is a substrate of TATProteinHuman-GEM MAR06780Inferred only
- CHEBI:17895 is a substrate of THProteinHuman-GEM MAR08537Inferred only
- CHEBI:17895 is a substrate of THProteinHuman-GEM MAR06728Inferred only
- CHEBI:17895 is a substrate of TPOProteinHuman-GEM MAR08544Inferred only
- CHEBI:17895 is a substrate of TPOProteinHuman-GEM MAR06793Inferred only
- CHEBI:17895 is a substrate of TTLProteinHuman-GEM MAR09505Inferred only
- CHEBI:17895 is a substrate of TYRProteinHuman-GEM MAR06729Inferred only
- CHEBI:17895 is a substrate of TYRProteinHuman-GEM MAR06874Inferred only
- CHEBI:17895 is a substrate of TYRProteinHuman-GEM MAR08541Inferred only
- CHEBI:17895 is a substrate of YARS1ProteinHuman-GEM MAR05130Inferred only
- CHEBI:17895 is transported by CLTRNProteinHuman-GEM MAR09908Inferred only
- CHEBI:17895 is transported by OCA2ProteinHuman-GEM MAR05062Inferred only
- CHEBI:17895 is transported by SLC16A10ProteinHuman-GEM MAR05074Inferred only
- CHEBI:17895 is transported by SLC36A1ProteinHuman-GEM MAR05074Inferred only
- CHEBI:17895 is transported by SLC3A1ProteinHuman-GEM MAR05914Inferred only
- CHEBI:17895 is transported by SLC3A1ProteinHuman-GEM MAR05978Inferred only
- CHEBI:17895 is transported by SLC3A1ProteinHuman-GEM MAR05946Inferred only
- CHEBI:17895 is transported by SLC3A1ProteinHuman-GEM MAR05930Inferred only
- CHEBI:17895 is transported by SLC3A1ProteinHuman-GEM MAR05962Inferred only
- CHEBI:17895 is transported by SLC3A2ProteinHuman-GEM MAR05074Inferred only
- CHEBI:17895 is transported by SLC43A1ProteinHuman-GEM MAR05074Inferred only
- CHEBI:17895 is transported by SLC6A14ProteinHuman-GEM MAR07657Inferred only
- CHEBI:17895 is transported by SLC6A18ProteinHuman-GEM MAR09908Inferred only
- CHEBI:17895 is transported by SLC6A19ProteinHuman-GEM MAR05318Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05491Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05503Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05514Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05524Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05533Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05542Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05543Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05544Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05545Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05546Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05593Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05608Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05548Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05623Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05638Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05653Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05668Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05549Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05074Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05464Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05547Inferred only
- CHEBI:17895 is transported by SLC7A5ProteinHuman-GEM MAR05478Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05946Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05862Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05863Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05623Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05683Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05694Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05695Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05699Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05702Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05706Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05819Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05864Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05865Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05866Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05914Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05930Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05962Inferred only
- CHEBI:17895 is transported by SLC7A6ProteinHuman-GEM MAR05978Inferred only
- CHEBI:17895 is transported by SLC7A7ProteinHuman-GEM MAR05074Inferred only
- CHEBI:17895 is transported by SLC7A8ProteinHuman-GEM MAR05074Inferred only
- CHEBI:17895 is transported by SLC7A9ProteinHuman-GEM MAR05914Inferred only
- CHEBI:17895 is transported by SLC7A9ProteinHuman-GEM MAR05930Inferred only
- CHEBI:17895 is transported by SLC7A9ProteinHuman-GEM MAR05978Inferred only
- CHEBI:17895 is transported by SLC7A9ProteinHuman-GEM MAR05946Inferred only
- CHEBI:17895 is transported by SLC7A9ProteinHuman-GEM MAR05962Inferred only
Reactions
154 reactions
L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR02299CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
Transported by OCA2
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR05062CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC16A10 or SLC36A1 or SLC43A1 or SLC7A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05074CC BY 4.0Reference data
proton+CHEBI:17895proton+CHEBI:17895
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, cytosol, mitochondrial matrix
Human-GEM MAR05099CC BY 4.0Reference data
ATP+MAM03081c+CHEBI:17895AMP+MAM02421c+diphosphate(3-)
Catalysed by YARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.1cytosol
Human-GEM MAR05130CC BY 4.0Reference data
MAM01308c+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by ALB
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05258CC BY 4.0Reference data
MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05259CC BY 4.0Reference data
MAM01343c+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05260CC BY 4.0Reference data
MAM01343l+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05261CC BY 4.0Reference data
MAM01345c+417ATP+834water417ADP+26L-alanine+7L-arginine+19L-asparagine+24L-aspartate+3L-cysteine+32L-glutamate(1-)+18L-glutamine+24glycine+432proton+13CHEBI:15971+20L-isoleucine+51L-leucine+34CHEBI:18019+10L-methionine+27L-phenylalanine+417phosphate(3-)+19CHEBI:17203+25L-seryl residue+30CHEBI:16857+3L-tryptophan+6CHEBI:17895+27L-valine
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05262CC BY 4.0Reference data
Where it reaches
10 systems, 24 regions, 64 tissues, 95 transporter routes — routes, not measurements: transporters known to carry CHEBI:17895 are expressed there, and no source reports it arriving.
Loading the model…
Other names
13 names
Resolves to: CHEBI:17895
- Also called
- (-)-alpha-amino-p-hydroxyhydrocinnamic acid(−)-α-amino-p-hydroxyhydrocinnamic acid(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid(S)-(-)-Tyrosine(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid(S)-3-(p-Hydroxyphenyl)alanine(S)-alpha-amino-4-hydroxybenzenepropanoic acid(S)-Tyrosine(S)-α-amino-4-hydroxybenzenepropanoic acid4-hydroxy-L-phenylalanineL-TyrosineTyrTyrosine