Endpoint
24-hour ambulatory systolic blood pressure
CAT:outcome/ambulatory-systolic-bp-24hreported in mmHg1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| spironolactone | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
spironolactone — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Compared with placebo and no treatment, spironolactone significantly reduced the 24-hour ambulatory SBP (WMD = −10.31, 95% CI = −12.86 to −7.76, P <.001) (WMD = −11.00, 95% CI = −19.25 to −2.75).”
Quoted verbatim from Clinical efficacy and safety of spironolactone in patients with resistant hypertension: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Patients with resistant hypertension, spironolactone added to background antihypertensive therapy versus placebo and versus no treatment, pooled from randomised trials
Effect -10.31 mean difference, 95% CI -12.86 to -7.76
Clinical efficacy and safety of spironolactone in patients with resistant hypertension: A systematic review and meta-analysis.2020PMID:32846786Permalink
How it is measured
Mean systolic pressure across a 24-hour ambulatory blood pressure monitoring recording, from an automated oscillometric device taking readings at fixed intervals through waking and sleeping hours. Device, sampling interval, and the proportion of valid readings recorded with each finding; a recording with too few valid readings is not this measurement.
Measured, not recorded
- Subject
- 24-hour ambulatory systolic blood pressure
- Measurements
- 9 measurements
- Recorded as a finding
- No
Show what was measured
24-hour ambulatory systolic blood pressure
decreases, GTN lowered 24 hour ambulatory systolic blood pressure by 7.9 mmHg (95% CI 0.1, 15.8), n = 127
GTN lowered 24 hour ambulatory systolic blood pressure by 7.9 mmHg (95% CI 0.1, 15.8) and increased heart rate (WMD 6.2 beats per minute, 95% CI 2.7, 9.8).
PMID:12519542 · both readings recorded this
24-hour ambulatory systolic blood pressure
decreases, -3.62 mmHg (95% CI -4.29, -2.94), SGLT-2 inhibitor vs placebo
CFB in 24-h systolic BP between SGLT-2 inhibitor and placebo groups was -3.62 mmHg (95% CI -4.29, -2.94) and in diastolic BP was -1.70 mmHg (95% CI -2.13, -1.26).
PMID:30894383 · one of two readings recorded this
24-hour ambulatory systolic blood pressure
decreases
Compared with placebo and no treatment, spironolactone significantly reduced the 24-hour ambulatory SBP (WMD = −10.31, 95% CI = −12.86 to −7.76, P <.001) (WMD = −11.00, 95% CI = −19.25 to −2.75)
PMID:32846786 · one of two readings recorded this
24-hour ambulatory systolic blood pressure
decreases, p = 0.001
Compared with placebo and no treatment, spironolactone significantly reduced the 24-hour ambulatory SBP (WMD = −10.31, 95% CI = −12.86 to −7.76, P <.001) (WMD = −11.00, 95% CI = −19.25 to −2.75)
PMID:32846786 · one of two readings recorded this
24-hour ambulatory systolic blood pressure
decreases, p = 0.05
in comparison with alternative drugs, spironolactone showed a significant difference in the reduction in 24-hour ambulatory SBP (WMD = −6.98, 95% CI = −12.66 to −1.30, P <.05)
PMID:32846786 · one of two readings recorded this
24-hour ambulatory systolic blood pressure
no effect
−8.53 (−24.71 to 7.60) | −8.82 (−31.06 to 13.45) | −5.73 (−23.41 to 11.75) | −6.33 (−28.47 to 15.85) | Vit C+E
PMID:38296289 · one of two readings recorded this
24-hour ambulatory systolic blood pressure
no effect
0.31 (−15.18 to 15.87) | Vit C | −5.04 (−15.01 to 4.97) | −4.66 (−17.73 to 8.24) | −10.14 (−23.53 to 3.08)
PMID:38296289 · one of two readings recorded this
24-hour ambulatory systolic blood pressure
no effect
−2.82 (−9.15 to 3.69) | −3.19 (−19.78 to 13.74) | Vit D | 0.46 (−9.21 to 9.92) | −5.06 (−15.50 to 5.12)
PMID:38296289 · one of two readings recorded this
24-hour ambulatory systolic blood pressure
no effect
−2.18 (−17.43 to 13.21) | −2.45 (−24.32 to 19.36) | 0.57 (−15.93 to 17.22) | Vit E | −5.51 (−18.43 to 7.57)
PMID:38296289 · one of two readings recorded this
Sources cited
1 paper
- Subject
- 24-hour ambulatory systolic blood pressure
- Findings
- 1
- Papers
- 1