Compound
urate
An oxidation product, via xanthine oxidase, of oxypurines such as xanthine and hypoxanthine. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals urate oxidase further oxidizes it to allantoin.
Structure
No depiction stored
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- Class
- Organic compound
- Formula
- C5H4N4O3
- Mass
- 168.112 g/mol
- Charge
- 0
- InChIKey
- LEHOTFFKMJEONL-UHFFFAOYSA-N
- SMILES
- O=c1nc(=O)c2nc(=O)nc2n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
15 entities
15 entities reached.
0 reported hops15 assembled from the scaffold
- XDHProteinUNIPROT:P47989metabolized byInferred only34 paths17 endpoints
- PXDNProteinUNIPROT:Q92626substrate ofInferred only20 paths10 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only20 paths10 endpoints
- PRDX6ProteinUNIPROT:P30041substrate ofInferred only15 paths15 endpoints
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- MPOProteinUNIPROT:P05164substrate ofInferred only13 paths13 endpoints
- SLC2A9ProteinUNIPROT:Q9NRM0transported byInferred only10 paths5 endpoints
- LPOProteinUNIPROT:P22079substrate ofInferred only10 paths5 endpoints
- SLC23A1ProteinUNIPROT:Q9UHI7transported byInferred only9 paths9 endpoints
- SLC2A2ProteinUNIPROT:P11168transported byInferred only6 paths5 endpoints
- EPXProteinUNIPROT:P11678substrate ofInferred only6 paths3 endpoints
- SLC29A2ProteinUNIPROT:Q14542transported byInferred only3 paths3 endpoints
What the reference databases state
Statements
53 statements
53 statements · 2 reference databases · Subject: urate · Sources: Human-GEM, Rhea
- 5-hydroxyisourate is converted to urateCompoundRhea RHEA:51532Inferred only
- urate is converted to 5-hydroxyisourateCompoundRhea RHEA:27329Inferred only
- urate is converted to 5-hydroxyisourateCompoundRhea RHEA:21368Inferred only
- urate is converted to 5-hydroxyisourateCompoundHuman-GEM MAR06611Inferred only
- 5-hydroxyisourate is converted to urateCompoundHuman-GEM MAR06611Inferred only
- 5-hydroxyisourate is converted to urateCompoundRhea RHEA:21368Inferred only
- 5-hydroxyisourate is converted to urateCompoundRhea RHEA:27329Inferred only
- urate is converted to 5-hydroxyisourateCompoundRhea RHEA:51532Inferred only
- xanthine is converted to urateCompoundHuman-GEM MAR04648Inferred only
- xanthine is converted to urateCompoundHuman-GEM MAR04649Inferred only
- xanthine is converted to urateCompoundHuman-GEM MAR04650Inferred only
- xanthine is converted to urateCompoundRhea RHEA:43120Inferred only
Show the remaining 41
- xanthine is converted to urateCompoundRhea RHEA:16669Inferred only
- xanthine is converted to urateCompoundRhea RHEA:21132Inferred only
- urate is converted to xanthineCompoundRhea RHEA:16669Inferred only
- urate is converted to xanthineCompoundRhea RHEA:21132Inferred only
- urate is converted to xanthineCompoundRhea RHEA:43120Inferred only
- xanthine is converted to urateCompoundHuman-GEM MAR04646Inferred only
- urate is metabolised by XDHProteinRhea RHEA:21132Inferred only
- urate is metabolised by XDHProteinRhea RHEA:16669Inferred only
- urate is a substrate of EPXProteinHuman-GEM MAR06603Inferred only
- urate is a substrate of EPXProteinHuman-GEM MAR06602Inferred only
- urate is a substrate of LPOProteinHuman-GEM MAR06602Inferred only
- urate is a substrate of LPOProteinHuman-GEM MAR06603Inferred only
- urate is a substrate of MPOProteinHuman-GEM MAR03263Inferred only
- urate is a substrate of PRDX6ProteinHuman-GEM MAR06602Inferred only
- urate is a substrate of PXDNProteinHuman-GEM MAR06602Inferred only
- urate is a substrate of PXDNProteinHuman-GEM MAR06603Inferred only
- urate is transported by ABCC4ProteinHuman-GEM MAR05446Inferred only
- urate is transported by ABCC4ProteinRhea RHEA:16461Inferred only
- urate is transported by ABCG2ProteinRhea RHEA:16461Inferred only
- urate is transported by SLC17A1ProteinRhea RHEA:60368Inferred only
- urate is transported by SLC17A2ProteinRhea RHEA:72319Inferred only
- urate is transported by SLC17A3ProteinRhea RHEA:72383Inferred only
- urate is transported by SLC17A4ProteinRhea RHEA:72319Inferred only
- urate is transported by SLC22A12ProteinRhea RHEA:72319Inferred only
- urate is transported by SLC22A12ProteinRhea RHEA:72003Inferred only
- urate is transported by SLC22A12ProteinHuman-GEM MAR09622Inferred only
- urate is transported by SLC22A12ProteinRhea RHEA:72023Inferred only
- urate is transported by SLC22A13ProteinRhea RHEA:72003Inferred only
- urate is transported by SLC22A13ProteinRhea RHEA:72011Inferred only
- urate is transported by SLC22A13ProteinRhea RHEA:72023Inferred only
- urate is transported by SLC22A13ProteinRhea RHEA:72007Inferred only
- urate is transported by SLC22A6ProteinRhea RHEA:76135Inferred only
- urate is transported by SLC22A7ProteinRhea RHEA:60368Inferred only
- urate is transported by SLC22A8ProteinRhea RHEA:72403Inferred only
- urate is transported by SLC22A8ProteinRhea RHEA:72551Inferred only
- urate is transported by SLC23A1ProteinRhea RHEA:76339Inferred only
- urate is transported by SLC29A2ProteinRhea RHEA:60368Inferred only
- urate is transported by SLC29A3ProteinRhea RHEA:60368Inferred only
- urate is transported by SLC2A2ProteinRhea RHEA:60368Inferred only
- urate is transported by SLC2A9ProteinHuman-GEM MAR09198Inferred only
- urate is transported by SLC2A9ProteinRhea RHEA:60368Inferred only
Reactions
40 reactions
Reaction pageLeft to rightUnbalancedEC 2.5.1.18cytosol
Human-GEM MAR03167CC BY 4.0Reference data
hydrogen peroxide+urateCHEBI:730073+2proton+urea
Catalysed by MPO
Reaction pageReversibleBalancedEC 1.11.1.7nucleus
Human-GEM MAR03263CC BY 4.0Reference data
water+NAD(+)+xanthineproton+NADH(2-)+urate
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.1.4cytosol
Human-GEM MAR04646CC BY 4.0Reference data
water+NAD(+)+xanthineproton+NADH(2-)+urate
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.1.4peroxisome
Human-GEM MAR04648CC BY 4.0Reference data
water+dioxygen+xanthinehydrogen peroxide+urate
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.3.2cytosol
Human-GEM MAR04649CC BY 4.0Reference data
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.3.2peroxisome
Human-GEM MAR04650CC BY 4.0Reference data
ATP+water+urateADP+proton+phosphate(3-)+urate
Transported by ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05446CC BY 4.0Reference data
hydrogen peroxide+urateCHEBI:730073+2proton+urea
Catalysed by PRDX6 or EPX or PXDN or LPO
Reaction pageReversibleBalancedEC 1.11.1.7cytosol
Human-GEM MAR06602CC BY 4.0Reference data
hydrogen peroxide+urateCHEBI:730073+2proton+urea
Catalysed by EPX or PXDN or LPO
Reaction pageReversibleBalancedEC 1.11.1.7extracellular space
Human-GEM MAR06603CC BY 4.0Reference data
Reaction pageReversibleUnbalancedcytosol
Human-GEM MAR06605CC BY 4.0Reference data
CHEBI:17208+MAM03119cmonodehydro-L-ascorbate radical+urate
Reaction pageReversibleBalancedcytosol
Human-GEM MAR06606CC BY 4.0Reference data
water+MAM03119cMAM02149c+urate
Reaction pageReversibleBalancedcytosol
Human-GEM MAR06607CC BY 4.0Reference data
On the label
Labelled products
1 product
Source: NIH DSLD · Ingredient: urate · 1 product · Declared amount per serving: Not stated
0 labels state an amount1 does not
- NewtonEverettSuperFlex-HHPUS Uricum Acidum Note: 4camount not statedper 3 Spray(s)DSLD:213178
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
7 systems, 12 regions, 31 tissues, 47 transporter routes — routes, not measurements: transporters known to carry urate are expressed there, and no source reports it arriving.
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Other names
5 names
Resolves to: urate
- Also called
- 2,6,8-trioxopurine2,6,8-trioxypurinepurine-2,6,8(1H,3H,9H)-trioneURIC ACID
- Systematic name
- 7,9-dihydro-1H-purine-2,6,8(3H)-trione