Compound
heme b
The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C34H30FeN4O4
- Mass
- 614.483 g/mol
- Charge
- -2
- InChIKey
- KABFMIBPWCXCRK-RGGAHWMASA-J
- SMILES
- C=CC1=C(C)C2=Cc3c(C=C)c(C)c4[n]3[Fe-2]35[n]6c(c(C)c(CCC(=O)[O-])c6=CC6=[N+]3C(=C4)C(C)=C6CCC(=O)[O-])=CC1=[N+]25
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- HMOX1ProteinUNIPROT:P09601substrate ofInferred only112 paths56 endpoints
- HMOX2ProteinUNIPROT:P30519substrate ofInferred only92 paths46 endpoints
- COX10ProteinUNIPROT:Q12887substrate ofInferred only20 paths5 endpoints
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- FLVCR2ProteinUNIPROT:Q9UPI3transported byInferred only13 paths13 endpoints
- SLC48A1ProteinUNIPROT:Q6P1K1transported byInferred only11 paths11 endpoints
- HCCSProteinUNIPROT:P53701substrate ofInferred only8 paths4 endpoints
- FLVCR1ProteinUNIPROT:Q9Y5Y0transported byInferred only3 paths3 endpoints
- SLC46A1ProteinUNIPROT:Q96NT5transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
46 statements
46 statements · 3 reference databases · Subject: heme b · Sources: Human-GEM, Rhea, UniProt
- COX15 requires the cofactor heme bProteinUniProt Q7KZN9Inferred only
- CYB561 requires the cofactor heme bProteinUniProt P49447Inferred only
- CYB561A3 requires the cofactor heme bProteinUniProt Q8NBI2Inferred only
- CYB561D1 requires the cofactor heme bProteinUniProt Q8N8Q1Inferred only
- CYB561D2 requires the cofactor heme bProteinUniProt O14569Inferred only
- CYBRD1 requires the cofactor heme bProteinUniProt Q53TN4Inferred only
- CYP21A2 requires the cofactor heme bProteinUniProt P08686Inferred only
- CYP4B1 requires the cofactor heme bProteinUniProt P13584Inferred only
- EPX requires the cofactor heme bProteinUniProt P11678Inferred only
- GUCY1B1 requires the cofactor heme bProteinUniProt Q02153Inferred only
- HHAT requires the cofactor heme bProteinUniProt Q5VTY9Inferred only
- IDO1 requires the cofactor heme bProteinUniProt P14902Inferred only
Show the remaining 34
- LPO requires the cofactor heme bProteinUniProt P22079Inferred only
- MPO requires the cofactor heme bProteinUniProt P05164Inferred only
- MT-CYB requires the cofactor heme bProteinUniProt P00156Inferred only
- NOS1 requires the cofactor heme bProteinUniProt P29475Inferred only
- NOS2 requires the cofactor heme bProteinUniProt P35228Inferred only
- NOS3 requires the cofactor heme bProteinUniProt P29474Inferred only
- PTGS1 requires the cofactor heme bProteinUniProt P23219Inferred only
- PTGS2 requires the cofactor heme bProteinUniProt P35354Inferred only
- PXDN requires the cofactor heme bProteinUniProt Q92626Inferred only
- PXDNL requires the cofactor heme bProteinUniProt A1KZ92Inferred only
- SDHC requires the cofactor heme bProteinUniProt Q99643Inferred only
- STEAP1 requires the cofactor heme bProteinUniProt Q9UHE8Inferred only
- STEAP2 requires the cofactor heme bProteinUniProt Q8NFT2Inferred only
- STEAP3 requires the cofactor heme bProteinUniProt Q658P3Inferred only
- STEAP4 requires the cofactor heme bProteinUniProt Q687X5Inferred only
- SUOX requires the cofactor heme bProteinUniProt P51687Inferred only
- THAP4 requires the cofactor heme bProteinUniProt Q8WY91Inferred only
- TPO requires the cofactor heme bProteinUniProt P07202Inferred only
- heme b is a substrate of COX10ProteinRhea RHEA:28070Inferred only
- heme b is a substrate of COX10ProteinHuman-GEM MAR20090Inferred only
- heme b is a substrate of COX10ProteinHuman-GEM MAR20091Inferred only
- heme b is a substrate of COX10ProteinHuman-GEM MAR20092Inferred only
- heme b is a substrate of HCCSProteinHuman-GEM MAR04762Inferred only
- heme b is a substrate of HCCSProteinRhea RHEA:22648Inferred only
- heme b is a substrate of HMOX1ProteinHuman-GEM MAR01450Inferred only
- heme b is a substrate of HMOX1ProteinRhea RHEA:21764Inferred only
- heme b is a substrate of HMOX2ProteinRhea RHEA:21764Inferred only
- heme b is a substrate of HMOX2ProteinHuman-GEM MAR01450Inferred only
- heme b is transported by ABCB6ProteinRhea RHEA:19261Inferred only
- heme b is transported by ABCG2ProteinHuman-GEM MAR09899Inferred only
- heme b is transported by FLVCR1ProteinRhea RHEA:75443Inferred only
- heme b is transported by FLVCR2ProteinRhea RHEA:75443Inferred only
- heme b is transported by SLC46A1ProteinHuman-GEM MAR07735Inferred only
- heme b is transported by SLC48A1ProteinRhea RHEA:75443Inferred only
Reactions
31 reactions
iron(2+)+protoporphyrin IX2proton+heme b
Catalysed by FECH
Reaction pageLeft to rightBalancedEC 4.98.1.1mitochondrial matrix
Human-GEM MAR01044CC BY 4.0Reference data
5proton+heme b+3NADPH(4-)+3dioxygenbiliverdin IXalpha+CO+iron(2+)+3water+3NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.14.18cytosol
Human-GEM MAR01450CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04760CC BY 4.0Reference data
MAM01358m+heme bferroheme c di-L-cysteine(2-) residue
Catalysed by HCCS
Reaction pageLeft to rightBalancedEC 4.4.1.17mitochondrial matrix
Human-GEM MAR04762CC BY 4.0Reference data
Transported by SLC46A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR07735CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09107CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR09717CC BY 4.0Reference data
ATP+water+heme bADP+proton+heme b+phosphate(3-)
Transported by ABCG2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09899CC BY 4.0Reference data
0.034511-cis-retinol+0.0172all-trans-18-hydroxyretinoate+0.0172all-trans-18-hydroxyretinoate+0.0172MAM00611c+0.0172MAM00611m+0.0172MAM00622c+0.0172MAM00622m+0.0345MAM00766c+0.0172MAM01008c+0.0172MAM01008r+0.0172MAM01022c+0.0172MAM01022r+0.0172MAM01024c+0.0172MAM01024r+0.0345MAM01026r+0.0172MAM01028c+0.0172MAM01028r+0.0172MAM01030c+0.0172MAM01030r+0.0172all-trans-4-oxoretinoate+0.0172all-trans-4-oxoretinoate+0.0345all-trans-4-oxoretinol+0.0345MAM01060c+0.03459-cis-retinol+0.0345biotin+0.0345MAM01600m+0.0345FADH2+0.0345MAM01924c+0.0345heme b+0.0345(S)-carnitine+0.0345(R)-lipoate+0.0345MAM02624c+0.0345CHEBI:18405+0.0345riboflavin+0.03455,6,7,8-tetrahydrobiopterin+0.03455,6,7,8-tetrahydrofolic acid+0.0345thiamine(1+) diphosphate+0.0345ubiquinolMAM10012c
Reaction pageLeft to rightBalance undeterminablecytosol, endoplasmic reticulum, mitochondrial matrix
Human-GEM MAR10065CC BY 4.0Reference data
iron(2+)+protoporphyrin IX2proton+heme b
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR11406CC BY 4.0Reference data
(2E,6E)-farnesyl diphosphate+water+heme bdiphosphate(3-)+Fe(II)-heme o
Catalysed by COX10
Reaction pageLeft to rightBalancedEC 2.5.1.-, 2.5.1.141mitochondrial matrix
Human-GEM MAR20090CC BY 4.0Reference data
(2E,6E)-farnesyl diphosphate+water+heme bdiphosphate(3-)+Fe(II)-heme o
Catalysed by COX10
Reaction pageLeft to rightBalancedEC 2.5.1.-, 2.5.1.141cytosol
Human-GEM MAR20091CC BY 4.0Reference data
Where it reaches
7 systems, 13 regions, 31 tissues, 43 transporter routes — routes, not measurements: transporters known to carry heme b are expressed there, and no source reports it arriving.
Loading the model…
Other names
4 names
Resolves to: heme b
- Also called
- Fe(II)-heme b(2-)Fe(II)-heme b(2−)
- Systematic name
- [3,3'-(3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-diyl-kappa(4)N(21),N(22),N(23),N(24))dipropanoato(4-)]ferrate(2-)[3,3'-(3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-diyl-κ4N21,N22,N23,N24)dipropanoato(4−)]ferrate(2−)