knowcompoundssodium nitrite
Specimen compound
Sodium nitrite
Nitrous acid sodium salt.
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Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in analytical chemistry techniques. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.”
- Formula
- NO2·Na
- Molar mass
- 68.995 g/mol
- ChEBI
- CHEBI:78870
- MeSH
- D012977
- InChIKey
- LPXPTNMVRIOKMN-UHFFFAOYSA-M
↑ raised 2 findings in 1 endpoint · – no difference found 1 in 1
01 · the evidence, ordered
What the evidence says
- Strong
- 0
- Moderate
- 2
- Limited
- 0
- Very limited
- 1
- Insufficient
- 1
Sodium nitrite
Most findings
- Plasma nitrite concentration×2
- CAT×1
- Systemic vascular resistance×1
8 compounds on the outer ring, not drawn
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02 · findings
What sodium nitrite moved, and by how much
- Dose studied: as its paper gave it.
- Evidence strength: computed from the study. How it is computed
4 shown
- Systemic vascular resistanceMoved: no difference foundEvidence: ModeratePaper: PMID 274582342016
- Who
- Adults with heart failure with preserved ejection fraction undergoing cardiac catheterization, measured at rest after a single 5-minute nebulization of inhaled sodium nitrite versus inhaled saline placebo
- Dose studied
- 90 mg nebulized sodium nitrite, single dose
Nitrite had no effect on resting pulmonary or systemic vascular resistance, VO2, CI, CaO2 – CvO2, or SVI compared to placebo.”
Quoted verbatim from Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction.RCTPermalink - Plasma nitrite concentrationMoved: raisesEvidence: Moderatereplicated ×1Paper: PMID 246394232014
- Who
- Subset of patients with acute ST-elevation myocardial infarction having plasma nitrite sampled before and 5 minutes after a 5-minute intravenous infusion of sodium nitrite or saline placebo before primary PCI; 17-patient substudy (11 nitrite, 6 placebo), measured 5 minutes after infusion
- Dose studied
- 70 umol sodium nitrite in 5 mL water, intravenous over 5 minutes
Plasma nitrite [mean (SD), µmol/L] was similar at baseline [0.76 (0.14) vs. 0.73 (0.08)] but higher in the nitrite group 5 min after ceasing infusion [1.42 (0.96) vs. 0.18 (0.08); P = 0.008].”
Quoted verbatim from Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI).RCTPermalink - Plasma nitrite concentrationMoved: raisesEvidence: Very limitedreplicated ×1Paper: PMID 266072492016
- Who
- middle-aged and older adults
- Dose studied
- 80 or 160 mg/day
Ten weeks of sodium nitrite (80 or 160 mg/day, capsules, TheraVasc; randomized, placebo control, double blind) increased plasma nitrite acutely (5- to 15-fold, P < 0.001 vs. placebo) and chronically (P < 0.10) and was well tolerated without symptomatic hypotension or clinically relevant elevations in blood methemoglobin.”
Quoted verbatim from Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.RCT · 2 monthsA later check left this paper out of the papers counted for sodium nitrite; the finding stays because it matches the quoted sentence.Permalink - CATMoved: inhibitsEvidence: InsufficientPaper: PMID 313726562020
- Who
- hepatic tissue, in vitro
- Dose studied
- not reported
This action was confirmed in complementary studies in which nitrite was found to be capable of inhibiting catalase activity in hepatic tissue in vitro (Supplementary material online, Figure S1).”
Quoted verbatim from Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling.in vitro · not in humansPermalink
No row matches these filters.
No dose is advised.
- Dose studied: as its paper gave it.
- Evidence strength: computed from the study. How it is computed
03 · identity
Structure
- Charge
- 0
- 3D model
- None at PubChem
- SMILES
- O=N[O-].[Na+]
04 · reach
What it touches on the way
1 entity · assembled from reference reactions
- CATProtein1 path · 1 endpointinferred
05 · the record
Sources
223
papers screened for sodium nitrite
- admitted
- 3
- read and discarded
- 163
- not read yet
- 57
- Documented interactions
- None reported
Sources cited
4 papers · 4 findings
1 cited, not among the papers admitted · 1 no extractable result
Show every paper citedHide the papers cited
Other names · 1
NaNO2