Compound
(S)-malate
An optically active form of malate having (S)-configuration.
Definition from ChEBI (CHEBI:15589), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C4H4O5
- Mass
- 132.071 g/mol
- Charge
- -2
- InChIKey
- BJEPYKJPYRNKOW-REOHCLBHSA-L
- SMILES
- O=C([O-])C[C@H](O)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
17 entities
17 entities reached.
0 reported hops17 assembled from the scaffold
- SLC25A10ProteinUNIPROT:Q9UBX3transported byInferred only360 paths45 endpoints
- SLC25A1ProteinUNIPROT:P53007transported byInferred only196 paths28 endpoints
- UCP2ProteinUNIPROT:P55851transported byInferred only94 paths47 endpoints
- SLC25A11ProteinUNIPROT:Q02978transported byInferred only66 paths22 endpoints
- FHProteinUNIPROT:P07954substrate ofInferred only66 paths22 endpoints
- MDH2ProteinUNIPROT:P40926substrate ofInferred only52 paths26 endpoints
- MDH1ProteinUNIPROT:P40925substrate ofInferred only46 paths23 endpoints
- ME1ProteinUNIPROT:P48163substrate ofInferred only40 paths20 endpoints
- SDHAProteinUNIPROT:P31040substrate ofInferred only27 paths27 endpoints
- ME2ProteinUNIPROT:P23368substrate ofInferred only24 paths8 endpoints
- SDHBProteinUNIPROT:P21912substrate ofInferred only21 paths21 endpoints
- PHGDHProteinUNIPROT:O43175substrate ofInferred only14 paths14 endpoints
Show the remaining 5
- ME3ProteinUNIPROT:Q16798substrate ofInferred only9 paths3 endpoints
- SUCLG1ProteinUNIPROT:P53597substrate ofInferred only7 paths7 endpoints
- SUCLA2ProteinUNIPROT:Q9P2R7substrate ofInferred only5 paths5 endpoints
- SLC25A30ProteinUNIPROT:Q5SVS4transported byInferred only4 paths2 endpoints
- SLC25A14ProteinUNIPROT:O95258transported byInferred only4 paths2 endpoints
What the reference databases state
Chemical structure
- (R)-malate is the enantiomer of (S)-malateCompoundChEBI CHEBI:15588Inferred only
Statements
80 statements
80 statements · 3 reference databases · Subject: (S)-malate · Sources: ChEBI, Human-GEM, Rhea
- (S)-malate is converted to (S)-lactateCompoundRhea RHEA:46276Inferred only
- (S)-lactate is converted to (S)-malateCompoundRhea RHEA:46276Inferred only
- (S)-malyl-CoA is converted to (S)-malateCompoundRhea RHEA:86303Inferred only
- (S)-malate is converted to (S)-malyl-CoACompoundRhea RHEA:26193Inferred only
- (S)-malate is converted to (S)-malyl-CoACompoundRhea RHEA:86303Inferred only
- (S)-malyl-CoA is converted to (S)-malateCompoundRhea RHEA:26193Inferred only
- (S)-malyl-CoA is converted to (S)-malateCompoundRhea RHEA:38291Inferred only
- disodium (S)-malate is converted to (S)-malateCompoundChEBI CHEBI:91261Inferred only
- fumaric acid is converted to (S)-malateCompoundRhea RHEA:12460Inferred only
- (S)-malate is converted to fumaric acidCompoundHuman-GEM MAR04410Inferred only
- fumaric acid is converted to (S)-malateCompoundHuman-GEM MAR04410Inferred only
- fumaric acid is converted to (S)-malateCompoundHuman-GEM MAR04408Inferred only
Show the remaining 68
- (S)-malate is converted to fumaric acidCompoundRhea RHEA:12460Inferred only
- (S)-malate is converted to fumaric acidCompoundHuman-GEM MAR04408Inferred only
- (S)-malate is converted to glyoxylateCompoundRhea RHEA:18181Inferred only
- glyoxylate is converted to (S)-malateCompoundRhea RHEA:18181Inferred only
- oxaloacetate is converted to (S)-malateCompoundHuman-GEM MAR04141Inferred only
- (S)-malate is converted to oxaloacetateCompoundRhea RHEA:10824Inferred only
- (S)-malate is converted to oxaloacetateCompoundHuman-GEM MAR08981Inferred only
- (S)-malate is converted to oxaloacetateCompoundHuman-GEM MAR04141Inferred only
- (S)-malate is converted to oxaloacetateCompoundHuman-GEM MAR04139Inferred only
- oxaloacetate is converted to (S)-malateCompoundHuman-GEM MAR04139Inferred only
- oxaloacetate is converted to (S)-malateCompoundHuman-GEM MAR08981Inferred only
- oxaloacetate is converted to (S)-malateCompoundRhea RHEA:10824Inferred only
- oxaloacetate is converted to (S)-malateCompoundRhea RHEA:21432Inferred only
- (S)-malate is converted to oxaloacetateCompoundRhea RHEA:21432Inferred only
- pyruvate is converted to (S)-malateCompoundRhea RHEA:12653Inferred only
- (S)-malate is converted to pyruvateCompoundHuman-GEM MAR04087Inferred only
- pyruvate is converted to (S)-malateCompoundRhea RHEA:18253Inferred only
- (S)-malate is converted to pyruvateCompoundRhea RHEA:18253Inferred only
- (S)-malate is converted to pyruvateCompoundRhea RHEA:12653Inferred only
- (S)-malate is converted to pyruvateCompoundHuman-GEM MAR04089Inferred only
- (S)-malate is converted to pyruvateCompoundHuman-GEM MAR04091Inferred only
- (S)-malate is a substrate of CLYBLProteinRhea RHEA:18181Inferred only
- (S)-malate is a substrate of FHProteinHuman-GEM MAR04410Inferred only
- (S)-malate is a substrate of FHProteinHuman-GEM MAR04408Inferred only
- (S)-malate is a substrate of FHProteinRhea RHEA:12460Inferred only
- (S)-malate is a substrate of MDH1ProteinHuman-GEM MAR04139Inferred only
- (S)-malate is a substrate of MDH1ProteinRhea RHEA:21432Inferred only
- (S)-malate is a substrate of MDH1BProteinHuman-GEM MAR04139Inferred only
- (S)-malate is a substrate of MDH2ProteinHuman-GEM MAR04141Inferred only
- (S)-malate is a substrate of MDH2ProteinRhea RHEA:21432Inferred only
- (S)-malate is a substrate of ME1ProteinRhea RHEA:18253Inferred only
- (S)-malate is a substrate of ME1ProteinHuman-GEM MAR04089Inferred only
- (S)-malate is a substrate of ME2ProteinHuman-GEM MAR04087Inferred only
- (S)-malate is a substrate of ME2ProteinRhea RHEA:12653Inferred only
- (S)-malate is a substrate of ME2ProteinHuman-GEM MAR04091Inferred only
- (S)-malate is a substrate of ME3ProteinRhea RHEA:18253Inferred only
- (S)-malate is a substrate of ME3ProteinHuman-GEM MAR04087Inferred only
- (S)-malate is a substrate of ME3ProteinHuman-GEM MAR04091Inferred only
- (S)-malate is a substrate of PHGDHProteinRhea RHEA:21432Inferred only
- (S)-malate is a substrate of RWDD2AProteinHuman-GEM MAR04089Inferred only
- (S)-malate is a substrate of SDHAProteinRhea RHEA:79831Inferred only
- (S)-malate is a substrate of SDHBProteinRhea RHEA:79831Inferred only
- (S)-malate is a substrate of SUCLA2ProteinRhea RHEA:26193Inferred only
- (S)-malate is a substrate of SUCLG1ProteinRhea RHEA:26193Inferred only
- (S)-malate is transported by SLC25A1ProteinHuman-GEM MAR04964Inferred only
- (S)-malate is transported by SLC25A1ProteinHuman-GEM MAR06291Inferred only
- (S)-malate is transported by SLC25A1ProteinHuman-GEM MAR06295Inferred only
- (S)-malate is transported by SLC25A1ProteinHuman-GEM MAR02216Inferred only
- (S)-malate is transported by SLC25A1ProteinRhea RHEA:72483Inferred only
- (S)-malate is transported by SLC25A1ProteinHuman-GEM MAR00125Inferred only
- (S)-malate is transported by SLC25A1ProteinHuman-GEM MAR02420Inferred only
- (S)-malate is transported by SLC25A10ProteinHuman-GEM MAR04867Inferred only
- (S)-malate is transported by SLC25A10ProteinRhea RHEA:29327Inferred only
- (S)-malate is transported by SLC25A10ProteinRhea RHEA:71607Inferred only
- (S)-malate is transported by SLC25A10ProteinRhea RHEA:71611Inferred only
- (S)-malate is transported by SLC25A10ProteinRhea RHEA:71615Inferred only
- (S)-malate is transported by SLC25A10ProteinHuman-GEM MAR06522Inferred only
- (S)-malate is transported by SLC25A10ProteinHuman-GEM MAR04868Inferred only
- (S)-malate is transported by SLC25A10ProteinHuman-GEM MAR04865Inferred only
- (S)-malate is transported by SLC25A11ProteinHuman-GEM MAR04855Inferred only
- (S)-malate is transported by SLC25A11ProteinHuman-GEM MAR04852Inferred only
- (S)-malate is transported by SLC25A11ProteinRhea RHEA:71587Inferred only
- (S)-malate is transported by SLC25A14ProteinRhea RHEA:71615Inferred only
- (S)-malate is transported by SLC25A14ProteinRhea RHEA:74555Inferred only
- (S)-malate is transported by SLC25A30ProteinRhea RHEA:71615Inferred only
- (S)-malate is transported by SLC25A30ProteinRhea RHEA:74555Inferred only
- (S)-malate is transported by UCP2ProteinRhea RHEA:73299Inferred only
- (S)-malate is transported by UCP2ProteinRhea RHEA:74555Inferred only
Reactions
60 reactions
citric acid+(S)-malatecitric acid+(S)-malate
Transported by SLC25A1
Reaction pageReversibleBalancedEC 4.2.1.56cytosol, mitochondrial matrix
Human-GEM MAR00125CC BY 4.0Reference data
isocitric acid+(S)-malateisocitric acid+(S)-malate
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02216CC BY 4.0Reference data
cis-aconitic acid+(S)-malatecis-aconitic acid+(S)-malate
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02420CC BY 4.0Reference data
(S)-malate+oxaloacetate(S)-malate+oxaloacetate
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol
Human-GEM MAR03949CC BY 4.0Reference data
(S)-malate+NAD(+)carbon dioxide+NADH(2-)+pyruvate
Reaction pageLeft to rightBalancedEC 1.1.1.38, 1.1.1.39mitochondrial matrix
Human-GEM MAR04087CC BY 4.0Reference data
(S)-malate+NADP(3-)carbon dioxide+NADPH(4-)+pyruvate
Reaction pageLeft to rightBalancedEC 1.1.1.38, 1.1.1.40cytosol
Human-GEM MAR04089CC BY 4.0Reference data
(S)-malate+NADP(3-)carbon dioxide+NADPH(4-)+pyruvate
Reaction pageLeft to rightBalancedEC 1.1.1.38, 1.1.1.40mitochondrial matrix
Human-GEM MAR04091CC BY 4.0Reference data
proton+NADH(2-)+oxaloacetate(S)-malate+NAD(+)
Reaction pageReversibleBalancedEC 1.1.1.37cytosol
Human-GEM MAR04139CC BY 4.0Reference data
proton+NADH(2-)+oxaloacetate(S)-malate+NAD(+)
Catalysed by MDH2
Reaction pageReversibleBalancedEC 1.1.1.37mitochondrial matrix
Human-GEM MAR04141CC BY 4.0Reference data
Catalysed by FH
Reaction pageReversibleBalancedEC 4.2.1.2cytosol
Human-GEM MAR04408CC BY 4.0Reference data
Catalysed by FH
Reaction pageReversibleBalancedEC 4.2.1.2mitochondrial matrix
Human-GEM MAR04410CC BY 4.0Reference data
2-oxoglutarate(2-)+(S)-malate2-oxoglutarate(2-)+(S)-malate
Transported by SLC25A11
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04852CC BY 4.0Reference data
Where it reaches
10 systems, 29 regions, 110 tissues, 127 transporter routes — routes, not measurements: transporters known to carry (S)-malate are expressed there, and no source reports it arriving.
Loading the model…
Other names
2 names
Resolves to: (S)-malate
- Also called
- L-malate
- Systematic name
- (2S)-2-hydroxybutanedioate