Compound
dGTP
A 2'-deoxyribonucleoside 5'-triphosphate(4−) that is the tetraanion of 2'-deoxyguanosine 5'-triphosphate (dGTP), arising from deprotonation of the four triphosphate OH groups; major species at pH 7.3.
Definition from ChEBI (CHEBI:61429), read 2026-09-23. CC BY 4.0.
Structure
No depiction stored
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- Class
- Organic compound, anion
- Formula
- C10H12N5O13P3
- Mass
- 503.15 g/mol
- Charge
- -4
- InChIKey
- HAAZLUGHYHWQIW-KVQBGUIXSA-J
- SMILES
- Nc1nc(=O)c2ncn([C@H]3C[C@H](O)[C@@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O3)c2n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Chemical structure
- N(2)-(1-hydroxy-2-oxoethyl)-dGTP has the functional parent dGTPCompoundChEBI CHEBI:141572Inferred only
- N(2)-(1-hydroxy-2-oxopropyl)-dGTP has the functional parent dGTPCompoundChEBI CHEBI:141569Inferred only
Statements
14 statements
14 statements · 1 reference database · Subject: dGTP · Sources: Rhea
- dGTP is converted to dGDPCompoundRhea RHEA:64936Inferred only
- dGDP is converted to dGTPCompoundRhea RHEA:27690Inferred only
- dGDP is converted to dGTPCompoundRhea RHEA:64936Inferred only
- dGTP is converted to dGMPCompoundRhea RHEA:64932Inferred only
- dGTP is converted to dGMPCompoundRhea RHEA:28362Inferred only
- dGMP is converted to dGTPCompoundRhea RHEA:64932Inferred only
- formate is converted to dGTPCompoundRhea RHEA:51624Inferred only
- dGTP is converted to formateCompoundRhea RHEA:51624Inferred only
- dGTP is a substrate of NUDT15ProteinRhea RHEA:28362Inferred only
- dGTP is a substrate of PARK7ProteinRhea RHEA:57248Inferred only
- dGTP is a substrate of PARK7ProteinRhea RHEA:57244Inferred only
- dGTP is a substrate of SAMHD1ProteinRhea RHEA:15193Inferred only
Show the remaining 2
- dGTP is transported by SLC25A33ProteinRhea RHEA:73559Inferred only
- dGTP is transported by SLC25A36ProteinRhea RHEA:73631Inferred only
Reactions
19 reactions
dGTP+water2'-deoxyguanosine+triphosphate+hydron
Catalysed by SAMHD1
Reaction pageLeft to rightBalanced
Rhea RHEA:15193CC BY 4.0Reference data
Catalysed by NME4 or AK1 or AK4 or AK9
Reaction pageLeft to rightBalanced
Rhea RHEA:27690CC BY 4.0Reference data
dGTP+waterdGMP+diphosphate(3-)+hydron
Catalysed by NUDT15
Reaction pageLeft to rightBalanced
Rhea RHEA:28362CC BY 4.0Reference data
dGTP+pyruvatedGDP+phosphoenolpyruvate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:30791CC BY 4.0Reference data
formate+GTP+hydrondGTP+carbon dioxide+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:51624CC BY 4.0Reference data
Reaction pageDirection not assertedBalanced
Rhea RHEA:52536CC BY 4.0Reference data
dGTP+methylglyoxalN(2)-(1-hydroxy-2-oxopropyl)-dGTP
Reaction pageDirection not assertedBalanced
Rhea RHEA:57212CC BY 4.0Reference data
CHEBI:34779+dGTPN(2)-(1-hydroxy-2-oxoethyl)-dGTP
Reaction pageDirection not assertedBalanced
Rhea RHEA:57216CC BY 4.0Reference data
N(2)-(1-hydroxy-2-oxopropyl)-dGTP+waterlactate+dGTP+hydron
Catalysed by PARK7
Reaction pageDirection not assertedBalanced
Rhea RHEA:57244CC BY 4.0Reference data
N(2)-(1-hydroxy-2-oxoethyl)-dGTP+waterdGTP+glycolate+hydron
Catalysed by PARK7
Reaction pageDirection not assertedBalanced
Rhea RHEA:57248CC BY 4.0Reference data
CHEBI:65317+dGTPCHEBI:73316+dGDP
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:62128CC BY 4.0Reference data
Reaction pageDirection not assertedBalanced
Rhea RHEA:62144CC BY 4.0Reference data
Where it reaches
7 systems, 13 regions, 39 tissues, 39 transporter routes — routes, not measurements: transporters known to carry dGTP are expressed there, and no source reports it arriving.
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Other names
6 names
Resolves to: dGTP
- Also called
- 2'-deoxyguanosine 5'-triphosphate2'-deoxyguanosine 5'-triphosphate tetraanion2'-deoxyguanosine 5'-triphosphate(4-)2'-deoxyguanosine 5'-triphosphate(4−)dGTP tetraanion
- Systematic name
- 2'-deoxy-5'-O-({[(phosphonatooxy)phosphinato]oxy}phosphinato)guanosine