Compound
sphing-4-enine 1-phosphate
The conjugate base of sphingosine 1-phosphate having an anionic phosphate group and a protonated amino group; major species at pH 7.3.
Definition from ChEBI (CHEBI:60119), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C18H37NO5P
- Mass
- 378.47 g/mol
- Charge
- -1
- InChIKey
- DUYSYHSSBDVJSM-KRWOKUGFSA-M
- SMILES
- CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H]([NH3+])COP(=O)([O-])[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
10 entities
10 entities reached.
0 reported hops10 assembled from the scaffold
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- SGPL1ProteinUNIPROT:O95470substrate ofInferred only12 paths12 endpoints
- SGPP2ProteinUNIPROT:Q8IWX5substrate ofInferred only9 paths9 endpoints
- SGPP1ProteinUNIPROT:Q9BX95substrate ofInferred only9 paths9 endpoints
- PLPP1ProteinUNIPROT:O14494substrate ofInferred only9 paths9 endpoints
- PLPP2ProteinUNIPROT:O43688substrate ofInferred only9 paths9 endpoints
- PLPP3ProteinUNIPROT:O14495substrate ofInferred only8 paths8 endpoints
- SPNS2ProteinUNIPROT:Q8IVW8transported byInferred only4 paths4 endpoints
- MFSD2BProteinUNIPROT:A6NFX1transported byInferred only4 paths4 endpoints
- ABCC1ProteinUNIPROT:P33527transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
12 statements
12 statements · 1 reference database · Subject: sphing-4-enine 1-phosphate · Sources: Rhea
- sphing-4-enine 1-phosphate is converted to sphing-4-enineCompoundRhea RHEA:27518Inferred only
- sphing-4-enine is converted to sphing-4-enine 1-phosphateCompoundRhea RHEA:35847Inferred only
- sphing-4-enine 1-phosphate is a substrate of PLPP1ProteinRhea RHEA:27518Inferred only
- sphing-4-enine 1-phosphate is a substrate of PLPP2ProteinRhea RHEA:27518Inferred only
- sphing-4-enine 1-phosphate is a substrate of PLPP3ProteinRhea RHEA:27518Inferred only
- sphing-4-enine 1-phosphate is a substrate of SGPL1ProteinRhea RHEA:33507Inferred only
- sphing-4-enine 1-phosphate is a substrate of SGPP1ProteinRhea RHEA:27518Inferred only
- sphing-4-enine 1-phosphate is a substrate of SGPP2ProteinRhea RHEA:27518Inferred only
- sphing-4-enine 1-phosphate is transported by ABCC1ProteinRhea RHEA:38951Inferred only
- sphing-4-enine 1-phosphate is transported by ABCG2ProteinRhea RHEA:38951Inferred only
- sphing-4-enine 1-phosphate is transported by MFSD2BProteinRhea RHEA:38667Inferred only
- sphing-4-enine 1-phosphate is transported by SPNS2ProteinRhea RHEA:38667Inferred only
Reactions
6 reactions
sphing-4-enine 1-phosphate+watersphing-4-enine+hydrogenphosphate
Catalysed by PLPP1 or PLPP3 or PLPP2 or SGPP2 or SGPP1
Reaction pageLeft to rightBalanced
Rhea RHEA:27518CC BY 4.0Reference data
sphing-4-enine 1-phosphate(2E)-hexadecenal+phosphoethanolamine
Catalysed by SGPL1
Reaction pageLeft to rightBalanced
Rhea RHEA:33507CC BY 4.0Reference data
sphing-4-enine+ATP(4-)sphing-4-enine 1-phosphate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:35847CC BY 4.0Reference data
sphing-4-enine 1-phosphatesphing-4-enine 1-phosphate
Transported by MFSD2B or SPNS2
Reaction pageDirection not assertedBalanced
Rhea RHEA:38667CC BY 4.0Reference data
sphing-4-enine-phosphocholine+watersphing-4-enine 1-phosphate+choline+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:38919CC BY 4.0Reference data
sphing-4-enine 1-phosphate+ATP(4-)+watersphing-4-enine 1-phosphate+ADP(3-)+hydrogenphosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:38951CC BY 4.0Reference data
Where it reaches
7 systems, 12 regions, 22 tissues, 22 transporter routes — routes, not measurements: transporters known to carry sphing-4-enine 1-phosphate are expressed there, and no source reports it arriving.
Loading the model…
Other names
4 names
Resolves to: sphing-4-enine 1-phosphate
- Also called
- (2S,3R,4E)-2-ammonio-3-hydroxyoctadec-4-en-1-yl phosphatesphingosine 1-phosphatesphingosine 1-phosphate anion
- Systematic name
- (2S,3R,4E)-2-azaniumyl-3-hydroxyoctadec-4-en-1-yl phosphate