Compound

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA

An acyl-CoA(4−) that is the tetraanion of (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oyl-CoA arising from deprotonation of the phosphate and diphosphate OH groups.

Definition from ChEBI (CHEBI:58677), read 2026-09-23. CC BY 4.0.

CHEBI:58677ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C48H76N7O20P3S
Mass: 1196.154 g/mol
Charge: -4
InChIKey: MNYDLIUNNOCPHG-FJWDCHQMSA-J
SMILES: [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@]([H])(C)CCC[C@@H](C)C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3OP(=O)([O-])[O-])[C@]1([H])[C@H](O)C2
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

1 entity

1 entities reached.

0 reported hops1 assembled from the scaffold

CYP8B1ProteinUNIPROT:Q9UNU6transported byInferred only4 paths2 endpoints

What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA · Sources: Human-GEM

Order

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA is a substrate of AMACRProteinHuman-GEM MAR00071Inferred only
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA is a substrate of AMACRProteinHuman-GEM MAR01632Inferred only
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA is transported by CYP8B1ProteinHuman-GEM MAR01629Inferred only
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA is transported by CYP8B1ProteinHuman-GEM MAR01631Inferred only

Reactions

11 reactions

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAMAM00618r
Catalysed by AMACR
Reaction pageLeft to rightBalancedEC 5.1.99.4GO:0005783
Human-GEM MAR00071CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP+CHEBI:1146900(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A5 or SLC27A2
Reaction pageLeft to rightBalancedEC 6.2.1.7GO:0005783
Human-GEM MAR01624CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP+CHEBI:1146900(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A5 or SLC27A2
Reaction pageLeft to rightBalancedEC 6.2.1.7GO:0005777
Human-GEM MAR01625CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP+CHEBI:1146900(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A5 or SLC27A2
Reaction pageLeft to rightBalancedEC 6.2.1.7GO:0005829
Human-GEM MAR01627CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
Transported by CYP8B1
Reaction pageReversibleBalancedEC 1.14.14.139GO:0005829, GO:0005777
Human-GEM MAR01629CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
Transported by CYP8B1
Reaction pageReversibleBalancedEC 1.14.14.139GO:0005829, GO:0005783
Human-GEM MAR01631CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAMAM00618x
Catalysed by AMACR
Reaction pageLeft to rightBalancedEC 5.1.99.4GO:0005777
Human-GEM MAR01632CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+ATP+water(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+ADP+proton+phosphate(3-)
Reaction pageLeft to rightBalancedGO:0005783, GO:0005777
Human-GEM MAR02285CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+A+waterCHEBI:59807+AH2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15733CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP(4-)+coenzyme A(4-)(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A2 or SLC27A5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22976CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoACHEBI:77251
Catalysed by AMACR
Reaction pageReversibleBalance undeterminable
Rhea RHEA:40455CC BY 4.0Reference data

Where it reaches

1 system, 1 region, 2 tissues, 2 transporter routes — routes, not measurements: transporters known to carry (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA are expressed there, and no source reports it arriving.

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Digestive

Other names

8 names

Resolves to: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA

Also called: (25R)-3,7,12-trihydroxycoprostanoyl-CoA(4-)(25R)-3,7,12-trihydroxycoprostanoyl-CoA(4−)(25R)-3alpha,7alpha,12alpha-trihydroxycoprostanoyl-CoA(4-)(25R)-3α,7α,12α-trihydroxycoprostanoyl-CoA(4−)(25R)-THCA-CoA(4-)(25R)-THCA-CoA(4−)
Systematic name: 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-{[(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl]sulfanyl}ethyl)amino]propyl}amino)butyl] diphosphate}3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-{[(25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oyl]sulfanyl}ethyl)amino]propyl}amino)butyl] diphosphate}