What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- AADATProteinUNIPROT:Q8N5Z0substrate ofInferred only30 paths10 endpoints
- DDCProteinUNIPROT:P20711substrate ofInferred only19 paths19 endpoints
- KYAT1ProteinUNIPROT:Q16773substrate ofInferred only18 paths9 endpoints
- KYAT3ProteinUNIPROT:Q6YP21substrate ofInferred only12 paths6 endpoints
- KMOProteinUNIPROT:O15229substrate ofInferred only10 paths10 endpoints
- KYNUProteinUNIPROT:Q16719substrate ofInferred only10 paths10 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only8 paths8 endpoints
What the reference databases state
Statements
18 statements
18 statements · 1 reference database · Subject: CHEBI:17380 · Sources: Human-GEM
- CHEBI:17380 is converted to 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoateCompoundHuman-GEM MAR04244Inferred only
- L-kynurenine is converted to CHEBI:17380CompoundHuman-GEM MAR04220Inferred only
- CHEBI:17380 is converted to L-kynurenineCompoundHuman-GEM MAR04220Inferred only
- xanthurenate is converted to CHEBI:17380CompoundHuman-GEM MAR03048Inferred only
- CHEBI:17380 is converted to xanthurenateCompoundHuman-GEM MAR03048Inferred only
- CHEBI:17380 is converted to xanthurenateCompoundHuman-GEM MAR04246Inferred only
- xanthurenate is converted to CHEBI:17380CompoundHuman-GEM MAR04246Inferred only
- CHEBI:17380 is a substrate of AADATProteinHuman-GEM MAR03048Inferred only
- CHEBI:17380 is a substrate of AADATProteinHuman-GEM MAR04244Inferred only
- CHEBI:17380 is a substrate of AADATProteinHuman-GEM MAR04246Inferred only
- CHEBI:17380 is a substrate of DDCProteinHuman-GEM MAR08091Inferred only
- CHEBI:17380 is a substrate of KMOProteinHuman-GEM MAR04220Inferred only
Show the remaining 6
- CHEBI:17380 is a substrate of KYAT1ProteinHuman-GEM MAR04244Inferred only
- CHEBI:17380 is a substrate of KYAT1ProteinHuman-GEM MAR04246Inferred only
- CHEBI:17380 is a substrate of KYAT3ProteinHuman-GEM MAR04246Inferred only
- CHEBI:17380 is a substrate of KYAT3ProteinHuman-GEM MAR04244Inferred only
- CHEBI:17380 is a substrate of KYNUProteinHuman-GEM MAR04225Inferred only
- CHEBI:17380 is transported by SLC7A5ProteinHuman-GEM MAR09736Inferred only
Reactions
8 reactions
CHEBI:17380+2-oxoglutarate(2-)L-glutamate(1-)+water+xanthurenate
Catalysed by AADAT
Reaction pageReversibleBalancedEC 2.6.1.7mitochondrial matrix
Human-GEM MAR03048CC BY 4.0Reference data
CHEBI:17380+water+NADP(3-)proton+L-kynurenine+NADPH(4-)+dioxygen
Catalysed by KMO
Reaction pageReversibleBalancedEC 1.14.13.9cytosol
Human-GEM MAR04220CC BY 4.0Reference data
CHEBI:17380+water3-hydroxyanthranilic acid+L-alanine
Catalysed by KYNU
Reaction pageLeft to rightBalancedEC 3.7.1.3cytosol
Human-GEM MAR04225CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate+L-glutamate(1-)
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageLeft to rightBalancedEC 2.6.1.7cytosol
Human-GEM MAR04244CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)L-glutamate(1-)+water+xanthurenate
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageReversibleBalancedEC 2.6.1.7cytosol
Human-GEM MAR04246CC BY 4.0Reference data
CHEBI:17380+protonMAM00786c+carbon dioxide
Catalysed by DDC
Reaction pageLeft to rightBalancedEC 4.1.1.28cytosol
Human-GEM MAR08091CC BY 4.0Reference data
CHEBI:17380+L-tryptophanCHEBI:17380+L-tryptophan
Transported by SLC7A5
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09736CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09865CC BY 4.0Reference data
Where it reaches
4 systems, 6 regions, 8 tissues, 8 transporter routes — routes, not measurements: transporters known to carry CHEBI:17380 are expressed there, and no source reports it arriving.
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Other names
5 names
Resolves to: CHEBI:17380
- Also called
- (2S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid3-(3-hydroxyanthraniloyl)-L-alanine3-Hydroxy-L-kynurenineL-3-hydroxykynurenine
- Systematic name
- 3-(2-amino-3-hydroxybenzoyl)-L-alanine