Endpoint
Femoral neck bone mineral density
CAT:outcome/femoral-neck-bmdreported in g/cm21 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| phylloquinone | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Every finding here is a null result.
Measured, no effect detected
1 finding
phylloquinone — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Changes in BMD at the total hip, femoral neck and lumbar spine and BTMs; CTX and P1NP did not differ significantly following either K1 or MK-4 supplementation compared to placebo.”
Quoted verbatim from The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial.. - Study
- RCT
- Dose
- 1 mg/day vitamin K1
- Population
- Post-menopausal women with osteoporosis and serum vitamin K1 of 0.4 µg/L or less, all on oral bisphosphonate with calcium and/or vitamin D; vitamin K1 arm against placebo, 18 months
The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial.2023PMID:37338608Permalink
How it is measured
Areal bone mineral density of the femoral neck region of interest by dual-energy X-ray absorptiometry, in grams per square centimetre. Scanner manufacturer, software version, and region-of-interest placement recorded with each finding; values are not comparable across manufacturers without conversion, and percentage change from baseline is not the same reported quantity as an absolute change in g/cm2.
Measured, not recorded
- Subject
- femoral neck bone mineral density
- Measurements
- 4 measurements
- Recorded as a finding
- No
Show what was measured
femoral neck bone mineral density
increases
Based on nine effect sizes, we found a marginally significant association between magnesium intake and femoral neck BMD (0.14; 0.001, 0.28)
PMID:26556742 · one of two readings recorded this
femoral neck bone mineral density
increases
femoral neck and hip bone mineral density increased 0.02 g/cm2 (0.01; 0.04)
PMID:33499250 · one of two readings recorded this
femoral neck bone mineral density
increases
Compared with calcium and vitamin D supplementation alone, combined interventions significantly increased lumbar spine (SMD = 0.31, 95% CI [0.06, 0.55]) and femoral neck BMD (SMD = 0.47, 95% CI [0.09, 0.84])
PMID:41470812 · one of two readings recorded this
femoral neck bone mineral density
no effect, pooled mean difference near 0.00 g/cm2
Overall, creatine combined with exercise did not meaningfully change femoral neck BMD versus placebo.
PMID:42141930 · one of two readings recorded this
Sources cited
1 paper
- Subject
- femoral neck bone mineral density
- Findings
- 1
- Papers
- 1