Endpoint
Vertebral fracture incidence
CAT:outcome/vertebral-fracture-incidencereported in proportion2 findings from 1 compound
What moved it
How to read these marks2 findings · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| Ca(2+) | no effect 1 · down 1 | 2 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
Reported to move it
1 finding
Ca(2+) — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In 26 randomised controlled trials, calcium supplements reduced the risk of total fracture (20 studies, n=58,573; relative risk 0.89, 95% confidence interval 0.81 to 0.96) and vertebral fracture (12 studies, n=48,967. 0.86, 0.74 to 1.00) but not hip (13 studies, n=56,648; 0.95, 0.76 to 1.18) or forearm fracture (eight studies, n=51,775; 0.96, 0.85 to 1.09).”
Quoted verbatim from Calcium intake and risk of fracture: systematic review.. - Study
- meta-analysis
- Participants
- 48,967
- Population
- Participants aged over 50; pooled randomised trials of calcium supplements, with or without vitamin D
Effect 0.86 risk ratio, 95% CI 0.74 to 1
Calcium intake and risk of fracture: systematic review.2015PMID:26420387Permalink
Measured, no effect detected
1 finding
Ca(2+) — no detected effect on
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull result“The association between calcium administration and hip fracture [risk ratio (RR) 1.56; 95% confidence interval (CI), 0.91 to 2.69, I2=28%; P=0.11], vertebral fracture (RR 0.95; 95% CI, 0.82 to 1.10, I2=0%; P=0.49) or other fractures (RR 0.83; 95% CI 0.65 to 1.06, I2=0%; P=0.14) was not significant in comparison to either no treatment or placebo administration.”
Quoted verbatim from Role of calcium &/or vitamin D supplementation in preventing osteoporotic fracture in the elderly: A systematic review & meta-analysis.. - Study
- meta-analysis
- Population
- Adults older than 50 years with a previous history of fracture; pooled randomised trials of calcium supplementation against placebo or no treatment
Effect 0.95 risk ratio, 95% CI 0.82 to 1.1
Role of calcium &/or vitamin D supplementation in preventing osteoporotic fracture in the elderly: A systematic review & meta-analysis.2023PMID:37602580Permalink
How it is measured
Proportion of participants with at least one new fracture of a vertebral body, ascertained by semi-quantitative or morphometric reading of spinal radiographs, or by clinically reported back-pain fracture, over the follow-up the source states. Whether the fractures were radiographically detected morphometric deformities or clinically symptomatic is recorded with each finding, since the two give very different event rates.
Measured, not recorded
- Subject
- vertebral fracture incidence
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
vertebral fracture incidence
no effect
No significant associations were found between calcium, vitamin D, or combined calcium and vitamin D supplements and the incidence of nonvertebral, vertebral, or total fractures
PMID:29279934 · one of two readings recorded this
Sources cited
2 papers
- Subject
- vertebral fracture incidence
- Findings
- 2
- Papers
- 2