Compound
acetylcholine
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Structure
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- Class
- Organic compound, cation
- Formula
- C7H16NO2
- Mass
- 146.21 g/mol
- Charge
- +1
- InChIKey
- OIPILFWXSMYKGL-UHFFFAOYSA-N
- SMILES
- CC(=O)OCC[N+](C)(C)C
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
10 entities
10 entities reached.
0 reported hops10 assembled from the scaffold
- VDAC1ProteinUNIPROT:P21796transported byInferred only228 paths199 endpoints
- ACHEProteinUNIPROT:P22303substrate ofInferred only66 paths22 endpoints
- CHATProteinUNIPROT:P28329substrate ofInferred only40 paths20 endpoints
- BCHEProteinUNIPROT:P06276substrate ofInferred only32 paths16 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only12 paths2 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only10 paths5 endpoints
- SLC22A1ProteinUNIPROT:O15245transported byInferred only6 paths3 endpoints
- SLC22A4ProteinUNIPROT:Q9H015transported byInferred only5 paths5 endpoints
- cholineCompoundCHEBI:15354converted toInferred only4 paths4 endpoints
- SLC22A3ProteinUNIPROT:O75751transported byInferred only4 paths4 endpoints
What the reference databases state
Statements
26 statements
26 statements · 2 reference databases · Subject: acetylcholine · Sources: Human-GEM, Rhea
- choline is converted to acetylcholineCompoundRhea RHEA:18821Inferred only
- acetylcholine is converted to cholineCompoundRhea RHEA:18821Inferred only
- acetylcholine is a substrate of ACHEProteinHuman-GEM MAR00641Inferred only
- acetylcholine is a substrate of ACHEProteinRhea RHEA:17561Inferred only
- acetylcholine is a substrate of ACHEProteinHuman-GEM MAR08421Inferred only
- acetylcholine is a substrate of BCHEProteinHuman-GEM MAR00641Inferred only
- acetylcholine is a substrate of BCHEProteinHuman-GEM MAR08421Inferred only
- acetylcholine is a substrate of CHATProteinRhea RHEA:18821Inferred only
- acetylcholine is a substrate of CHATProteinHuman-GEM MAR08362Inferred only
- acetylcholine is transported by SLC18A3ProteinHuman-GEM MAR00058Inferred only
- acetylcholine is transported by SLC18A3ProteinHuman-GEM MAR07681Inferred only
- acetylcholine is transported by SLC18A3ProteinRhea RHEA:72891Inferred only
Show the remaining 14
- acetylcholine is transported by SLC22A1ProteinHuman-GEM MAR06245Inferred only
- acetylcholine is transported by SLC22A1ProteinRhea RHEA:74663Inferred only
- acetylcholine is transported by SLC22A2ProteinHuman-GEM MAR06245Inferred only
- acetylcholine is transported by SLC22A2ProteinRhea RHEA:74663Inferred only
- acetylcholine is transported by SLC22A3ProteinHuman-GEM MAR06245Inferred only
- acetylcholine is transported by SLC22A4ProteinRhea RHEA:74663Inferred only
- acetylcholine is transported by SLCO1A2ProteinHuman-GEM MAR06216Inferred only
- acetylcholine is transported by SLCO1A2ProteinHuman-GEM MAR01906Inferred only
- acetylcholine is transported by SLCO1A2ProteinHuman-GEM MAR01904Inferred only
- acetylcholine is transported by SLCO1B3ProteinHuman-GEM MAR01905Inferred only
- acetylcholine is transported by SLCO1B3ProteinHuman-GEM MAR06216Inferred only
- acetylcholine is transported by SLCO1B3ProteinHuman-GEM MAR01904Inferred only
- acetylcholine is transported by SLCO1B3ProteinHuman-GEM MAR01906Inferred only
- acetylcholine is transported by VDAC1ProteinRhea RHEA:74663Inferred only
Reactions
17 reactions
acetylcholine+ATP+wateracetylcholine+ADP+proton+phosphate(3-)
Transported by SLC18A3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00058CC BY 4.0Reference data
CHEBI:15351+cholineacetylcholine+CHEBI:1146900
Catalysed by CHAT
Reaction pageLeft to rightBalancedEC 2.3.1.6cytosol
Human-GEM MAR00640CC BY 4.0Reference data
acetylcholine+wateracetate+choline+proton
Reaction pageLeft to rightBalancedEC 3.1.1.7, 3.1.1.8cytosol
Human-GEM MAR00641CC BY 4.0Reference data
acetylcholine+MAM01980c+hydrogencarbonateacetylcholine+MAM01980e+hydrogencarbonate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalance undeterminableextracellular space, cytosol
Human-GEM MAR01904CC BY 4.0Reference data
acetylcholine+hydrogencarbonate+2,4-dinitrophenyl-S-glutathioneacetylcholine+hydrogencarbonate+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01905CC BY 4.0Reference data
acetylcholine+hydrogencarbonate+MAM02901cacetylcholine+hydrogencarbonate+MAM02901e
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01906CC BY 4.0Reference data
acetylcholine+CHEBI:16856+hydrogencarbonateacetylcholine+CHEBI:16856+hydrogencarbonate
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06216CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06245CC BY 4.0Reference data
3acetylcholine+2ATP+2water3acetylcholine+2ADP+2proton+2phosphate(3-)
Transported by SLC18A3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07681CC BY 4.0Reference data
acetylcholine+CHEBI:1146900CHEBI:15351+choline
Catalysed by CHAT
Reaction pageReversibleBalancedEC 2.3.1.6nucleus
Human-GEM MAR08362CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR08363CC BY 4.0Reference data
acetylcholine+wateracetate+choline+proton
Reaction pageLeft to rightBalancedEC 3.1.1.7, 3.1.1.8extracellular space
Human-GEM MAR08421CC BY 4.0Reference data
Where it reaches
10 systems, 28 regions, 186 tissues, 196 transporter routes — routes, not measurements: transporters known to carry acetylcholine are expressed there, and no source reports it arriving.
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Other names
5 names
Resolves to: acetylcholine
- Also called
- AChAzetylcholincholine acetateO-Acetylcholine
- Systematic name
- 2-acetyloxy-N,N,N-trimethylethanaminium