Endpoint
Postprandial blood glucose area under the curve
CAT:outcome/postprandial-glucose-aucreported in mmol/L x min1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-isoleucine | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
1 finding
L-isoleucine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Compared with the control, isoleucine-10g reduced the blood glucose AUC and peak blood glucose (P < 0.01), whereas effects of isoleucine-5g were NS.”
Quoted verbatim from Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.. - Study
- crossover
- Dose
- 10 g isoleucine, single intragastric infusion, 15 min before a mixed-nutrient drink
- Population
- healthy, lean subjects; isoleucine 10 g intragastric dose (isoleucine 5 g dose was not significant)
Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.2017PMID:27655440Permalink
How it is measured
Incremental area under the blood glucose concentration-time curve over 60 to 120 minutes following a fixed mixed-nutrient drink or oral glucose load, from serial venous or capillary sampling. Sampling window and load composition recorded with each finding.
Sources cited
1 paper
- Subject
- postprandial blood glucose area under the curve
- Findings
- 1
- Papers
- 1