Compound
leukotriene C4
The conjugation product of leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular smooth muscle. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C30H45N3O9S
- Mass
- 623.769 g/mol
- Charge
- -2
- InChIKey
- GWNVDXQDILPJIG-NXOLIXFESA-L
- SMILES
- CCCCC/C=CC/C=CC=CC=C[C@@H](SC[C@H](NC(=O)CC[C@H]([NH3+])C(=O)[O-])C(=O)NCC(=O)[O-])[C@@H](O)CCCC(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
18 entities
18 entities reached.
0 reported hops18 assembled from the scaffold
- GGT1ProteinUNIPROT:P19440substrate ofInferred only136 paths34 endpoints
- ABCA8ProteinUNIPROT:O94911transported byInferred only98 paths48 endpoints
- GGT5ProteinUNIPROT:P36269substrate ofInferred only92 paths23 endpoints
- RALBP1ProteinUNIPROT:Q15311transported byInferred only35 paths35 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- GGT6ProteinUNIPROT:Q6P531substrate ofInferred only27 paths9 endpoints
- GGT7ProteinUNIPROT:Q9UJ14substrate ofInferred only27 paths9 endpoints
- GSTM4ProteinUNIPROT:Q03013metabolized byInferred only26 paths26 endpoints
- LTC4SProteinUNIPROT:Q16873substrate ofInferred only20 paths20 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only18 paths2 endpoints
- ABCC2ProteinUNIPROT:Q92887transported byInferred only15 paths15 endpoints
- MGST3ProteinUNIPROT:O14880substrate ofInferred only11 paths11 endpoints
Show the remaining 6
- MGST2ProteinUNIPROT:Q99735substrate ofInferred only10 paths10 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only6 paths2 endpoints
- CPA1ProteinUNIPROT:P15085substrate ofInferred only4 paths4 endpoints
- ABCC1ProteinUNIPROT:P33527transported byInferred only4 paths2 endpoints
- ABCC6ProteinUNIPROT:O95255transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
48 statements
48 statements · 2 reference databases · Subject: leukotriene C4 · Sources: Human-GEM, Rhea
- leukotriene C4 is converted to CHEBI:28666CompoundHuman-GEM MAR04796Inferred only
- leukotriene C4 is converted to CHEBI:28666CompoundHuman-GEM MAR08548Inferred only
- CHEBI:28666 is converted to leukotriene C4CompoundHuman-GEM MAR08548Inferred only
- leukotriene C4 is converted to leukotriene D4CompoundRhea RHEA:31563Inferred only
- leukotriene C4 is metabolised by GSTM4ProteinRhea RHEA:17617Inferred only
- leukotriene C4 is a substrate of CPA1ProteinRhea RHEA:50740Inferred only
- leukotriene C4 is a substrate of GGT1ProteinRhea RHEA:31563Inferred only
- leukotriene C4 is a substrate of GGT1ProteinHuman-GEM MAR04796Inferred only
- leukotriene C4 is a substrate of GGT1ProteinHuman-GEM MAR08548Inferred only
- leukotriene C4 is a substrate of GGT1ProteinHuman-GEM MAR01084Inferred only
- leukotriene C4 is a substrate of GGT5ProteinRhea RHEA:31563Inferred only
- leukotriene C4 is a substrate of GGT5ProteinHuman-GEM MAR04796Inferred only
Show the remaining 36
- leukotriene C4 is a substrate of GGT5ProteinHuman-GEM MAR01084Inferred only
- leukotriene C4 is a substrate of GGT5ProteinHuman-GEM MAR08548Inferred only
- leukotriene C4 is a substrate of GGT6ProteinHuman-GEM MAR01084Inferred only
- leukotriene C4 is a substrate of GGT6ProteinHuman-GEM MAR04796Inferred only
- leukotriene C4 is a substrate of GGT6ProteinHuman-GEM MAR08548Inferred only
- leukotriene C4 is a substrate of GGT7ProteinHuman-GEM MAR08548Inferred only
- leukotriene C4 is a substrate of GGT7ProteinHuman-GEM MAR04796Inferred only
- leukotriene C4 is a substrate of GGT7ProteinHuman-GEM MAR01084Inferred only
- leukotriene C4 is a substrate of GGTLC1ProteinHuman-GEM MAR08548Inferred only
- leukotriene C4 is a substrate of GGTLC1ProteinHuman-GEM MAR01084Inferred only
- leukotriene C4 is a substrate of GGTLC2ProteinHuman-GEM MAR04796Inferred only
- leukotriene C4 is a substrate of GGTLC2ProteinHuman-GEM MAR01084Inferred only
- leukotriene C4 is a substrate of GGTLC2ProteinHuman-GEM MAR08548Inferred only
- leukotriene C4 is a substrate of GGTLC3ProteinHuman-GEM MAR04796Inferred only
- leukotriene C4 is a substrate of LTC4SProteinRhea RHEA:17617Inferred only
- leukotriene C4 is a substrate of MGST2ProteinRhea RHEA:17617Inferred only
- leukotriene C4 is a substrate of MGST3ProteinRhea RHEA:17617Inferred only
- leukotriene C4 is transported by ABCA8ProteinRhea RHEA:65960Inferred only
- leukotriene C4 is transported by ABCA8ProteinHuman-GEM MAR09893Inferred only
- leukotriene C4 is transported by ABCC1ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by ABCC1ProteinHuman-GEM MAR01082Inferred only
- leukotriene C4 is transported by ABCC10ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by ABCC11ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by ABCC2ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by ABCC3ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by ABCC4ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by ABCC6ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by RALBP1ProteinRhea RHEA:38963Inferred only
- leukotriene C4 is transported by SLCO1B1ProteinHuman-GEM MAR06103Inferred only
- leukotriene C4 is transported by SLCO1B1ProteinHuman-GEM MAR06126Inferred only
- leukotriene C4 is transported by SLCO1B1ProteinHuman-GEM MAR06127Inferred only
- leukotriene C4 is transported by SLCO1B1ProteinHuman-GEM MAR08551Inferred only
- leukotriene C4 is transported by SLCO1B1ProteinRhea RHEA:72743Inferred only
- leukotriene C4 is transported by SLCO1B1ProteinHuman-GEM MAR06128Inferred only
- leukotriene C4 is transported by SLCO1B3ProteinHuman-GEM MAR08551Inferred only
- leukotriene C4 is transported by SLCO1B3ProteinRhea RHEA:72743Inferred only
Reactions
21 reactions
CHEBI:16856+leukotriene A4leukotriene C4
Catalysed by LTC4S
Reaction pageLeft to rightBalancedEC 4.4.1.20cytosol
Human-GEM MAR01081CC BY 4.0Reference data
Transported by ABCC1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01082CC BY 4.0Reference data
proton+leukotriene C4MAM01111e+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageLeft to rightBalancedEC 2.3.2.2extracellular space
Human-GEM MAR01084CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2cytosol
Human-GEM MAR04796CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+leukotriene C4CHEBI:16856+hydrogencarbonate+leukotriene C4
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06103CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+leukotriene C4MAM01980e+hydrogencarbonate+leukotriene C4
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR06126CC BY 4.0Reference data
hydrogencarbonate+leukotriene C4+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+leukotriene C4+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06127CC BY 4.0Reference data
hydrogencarbonate+leukotriene C4+MAM02901chydrogencarbonate+leukotriene C4+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06128CC BY 4.0Reference data
water+leukotriene C4glycine+leukotriene F4
Reaction pageReversibleBalancedcytosol
Human-GEM MAR08547CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageReversibleBalancedEC 2.3.2.2endoplasmic reticulum
Human-GEM MAR08548CC BY 4.0Reference data
CHEBI:16856+leukotriene A4leukotriene C4
Catalysed by LTC4S
Reaction pageLeft to rightBalancedEC 4.4.1.20endoplasmic reticulum
Human-GEM MAR08550CC BY 4.0Reference data
hydrogencarbonate+leukotriene C4hydrogencarbonate+leukotriene C4
Transported by SLCO1B3 or SLCO1B1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08551CC BY 4.0Reference data
Where it reaches
9 systems, 25 regions, 97 tissues, 131 transporter routes — routes, not measurements: transporters known to carry leukotriene C4 are expressed there, and no source reports it arriving.
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Other names
3 names
Resolves to: leukotriene C4
- Also called
- leukotriene C4 dianionLTC4
- Systematic name
- (5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-{[(4S)-4-azaniumyl-4-carboxylatobutanoyl]amino}-3-[(carboxylatomethyl)amino]-3-oxopropyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoate