Endpoint
Serum albumin
A major protein in the blood. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
CAT:outcome/serum-albuminreported in g/dL4 findings from 4 compounds
What moved it
How to read these marks4 findings · 4 compounds · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| all-cis-5,8,11,14,17-icosapentaenoic acid | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| Lactiplantibacillus plantarum | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| resveratrol | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| sodium benzoate | up | 1 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
Reported to move it
3 findings
all-cis-5,8,11,14,17-icosapentaenoic acid — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Serum albumin was significantly higher in the EPA-rich fish oil group than the controls (p = 0.03), however this difference was not clinically significant.”
Quoted verbatim from Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.. - Study
- RCT
- Participants
- 24
- Duration
- 3 weeks
- Dose
- 1.5 g/day EPA as EPA-rich fish oil capsules (500 mg EPA per capsule, three times daily with meals)
- Population
- Hospitalised adults aged 18-65 with non-severe burns covering less than 20% of total body surface area, able to take more than 90% of their daily calorie requirement by mouth, without diabetes, organ failure, cancer or immune disorder; both the EPA arm and the control arm also received 600 mg/day DHA.
Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.2025PMID:41254027Permalink
Lactiplantibacillus plantarum — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Notably, total protein, albumin, and globulin levels increased significantly in the probiotic group relative to placebo (Δ0–6: total protein 3.54 vs. 0.63 g/L, p = 0.014; albumin 2.94 vs. 0.97 g/L, p = 0.017; globulin 1.61 vs. −0.36 g/L, p = 0.005), indicating a possible supportive effect on protein metabolism and immune-related globulin synthesis.”
Quoted verbatim from Safety of Lactiplantibacillus plantarum K014 in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.. - Study
- RCT
- Duration
- 6 months
- Dose
- one sachet daily, at least 1 x 10^9 CFU L. plantarum K014 with 2 g maltodextrin, for 24 weeks
- Population
- Healthy Malaysian adults aged 18 and over; change from baseline to month 6; maltodextrin placebo in the comparator arm
Safety of Lactiplantibacillus plantarum K014 in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.2026PMID:42124006Permalink
sodium benzoate — increases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“In male rats of the 2.4% group, relative liver and kidney weight, serum levels of albumin, total protein and gamma-glutamyl transpeptidase were significantly increased and enlarged hepatocytes with glassy cytoplasm were seen using light microscopy.”
Quoted verbatim from Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 2.4% sodium benzoate in diet
- Population
- male F344 rats, 2.4% sodium benzoate in diet for 10 days
Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.1993PMID:8212059Permalink
Measured, no effect detected
1 finding
resveratrol — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“However, the circulating values of albumin and uric acid were not affected by resveratrol supplementation.”
Quoted verbatim from Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.. - Study
- meta-analysis
- Population
- Adults; pooled meta-analysis of RCTs of resveratrol supplementation on renal function outcomes (31 studies).
Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.2025PMID:40580309Permalink
How it is measured
Serum albumin concentration by clinical colorimetric dye-binding assay. The dye is recorded with each finding, because bromocresol green reads systematically higher than bromocresol purple at low albumin concentrations, which is precisely the range nutritional studies operate in.
Measured, not recorded
- Subject
- serum albumin
- Measurements
- 23 measurements
- Recorded as a finding
- No
Show what was measured
Serum albumin
MD=0.10, 95% CI 0.02-0.18, n = 356
There was statistically significant difference between Gln and control group (MD: 0.10; 95% CI: 0.02–0.18; P < 0.05).
PMID:25591570 · one of two readings recorded this
Serum albumin
increases
serum albumin (WMD 3.07 g/L; 95% CI 1.59 to 4.55)
PMID:32186018 · one of two readings recorded this
Serum albumin
increases, p = 0.001
Albumin | 2.51 | 2.13–2.90 | 7.25 | P<0.001 | 81.4 | 0.282 | 0.338
PMID:32490516 · one of two readings recorded this
Serum albumin
increases, p = 0.001
Type 1 | 3.52 | 3.18–3.84 | 20.76 | P<0.001 | 62.9 | 0.400 | 0.284
PMID:32490516 · one of two readings recorded this
Serum albumin
increases, p = 0.001
Type 2 | 3.96 | 3.05–3.75 | 18.99 | P<0.001 | 55.3 | 0.282 | 0.198
PMID:32490516 · one of two readings recorded this
Serum albumin
increases, p = 0.001
Type 3 | 3.58 | 3.23–3.94 | 19.84 | P<0.001 | 60.2 | 0.370 | 0.444
PMID:32490516 · one of two readings recorded this
Serum albumin
increases, p = 0.001
Type 4 | 1.32 | 0.80–1.23 | 8.890 | P<0.001 | 75.5 | 0.494 | 0.573
PMID:32490516 · one of two readings recorded this
serum albumin
increases, significantly higher means in treatment group, n = 51
By contrast, the treatment group revealed significantly higher means for muscle mass, albumin and BHB (Table 2).
PMID:33322022 · one of two readings recorded this
serum albumin
no effect
However, with the exception for proteinuria, their impact on clinical parameters, such as blood urea nitrogen, creatinine, glomerular filtration rate (GFR), and serum albumin, was weak and not significant.
PMID:34331699 · one of two readings recorded this
serum albumin
increases, SMD = 1.02, 95% CI: 0.74-1.31, n = 917
Not recorded as a finding: the serum-albumin node requires the colorimetric dye (bromocresol green vs purple) to be recorded with each finding, which this pooled meta-analysis never states
The pooled estimates showed that Gln supplementation significantly increased serum albumin level (SMD = 1.02, 95% CI: 0.74–1.31, P < 0.00001; Figure 10).
PMID:35774540 · one of two readings recorded this
Serum albumin
decreases, p = 0.001, n = 120
lower serum albumin values (3.5 g/dL vs. 4.2 g/dL; p < 0.001)
PMID:36005169 · one of two readings recorded this
Serum albumin
increases
serum albumin (MD = 3.75, 95% CI [3.01, 4.49], P = .000)
PMID:36862887 · one of two readings recorded this
serum albumin
increases, p = 0.001, n = 94
Compared to the control group, patients in the colostrum group had a 0.31 score more appetite (P < 0.001), 0.17 g/dL higher serum albumin level (P = 0.001), 0.5 mg/dL higher hemoglobin level and 440 more blood lymphocytes (P < 0.001) during the 30 days of intervention
PMID:38042695 · one of two readings recorded this
serum albumin
increases, 3.26 vs 2.97 mg/dl at end of study, p = 0.031, n = 52
Albumin concentration was higher in the subjects receiving CoQ10 compared to the placebo group (P = 0.031) at the end of the intervention.
PMID:38431600 · one of two readings recorded this
serum albumin
Control group | 46.12 ± 0.13 a | 12.78 ± 1.00 a | 36.15 ± 1.07 a
PMID:41246396 · one of two readings recorded this
serum albumin
decreases
Sodium benzoate (200 mg/kg) | 36.00 ± 0.42 b | 8.11 ± 0.06 b | 30.11 ± 0.08 b
PMID:41246396 · one of two readings recorded this
serum albumin
decreases
Sodium benzoate (300 mg/kg) | 29.98 ± 0.05 c | 5.23 ± 0.14 c | 25.32 ± 0.47 c
PMID:41246396 · one of two readings recorded this
serum albumin
no effect, p = 0.778, n = 84
Albumin (g/L) | 36.1 ± 4.6 | 36.4 ± 5.1 | 0.3 (-1.808 to 2.408) | 0.778
PMID:41449463 · one of two readings recorded this
serum albumin
decreases, p = 0.011, n = 194
Albumin (g/dL) | 4.5 (4.2–4.8) | 4.6 (4.3–4.8) | 4.3(3.8–4.6) | 4.1 (3.7–4.5) | 0.011c
PMID:41456031 · one of two readings recorded this
serum albumin
decreases, p = 0.0001
Additionally, serum albumin levels decreased significantly from 4.97 ± 1.63 g/dL at baseline to 4.58 ± 1.38 g/dL at 12 weeks (5.09% reduction, p < 0.0001) with mean change of –0.39 g/dL [95% CI: –0.44 to –0.35].
PMID:41650186 · one of two readings recorded this
serum albumin
decreases, p = 0.0001
Sr. Albumin (g/dL) | PB Week 12 - Baseline | -0.39 | 0.82 | 0.02 | -0.44 | -0.35 | <0.0001
PMID:41650186 · one of two readings recorded this
Serum albumin
MD=2.32 g/L, 95% CI 1.06-3.58, p = 0.0003
The overall analysis showed that the difference between the two groups was statistically significant (MD = 2.32 g/L, 95%CI: 1.06-3.58, Z=3.61, P=0.0003).
PMID:41891764 · one of two readings recorded this
Serum albumin
decreases, n = 10
Creatine supplementation produced a modest reduction in serum albumin that remained within physiological reference ranges
PMID:42669527 · one of two readings recorded this
Sources cited
4 papers
- Subject
- serum albumin
- Findings
- 4
- Papers
- 4
Safety of Lactiplantibacillus plantarum K014 in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.record2026PMID:421240061 finding
Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.record2025PMID:405803091 finding
Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.record2025PMID:412540271 finding
Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.record1993PMID:82120591 finding