Compound
11-deoxycortisol
17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.
Structure
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- Class
- Organic compound
- Formula
- C21H30O4
- Mass
- 346.467 g/mol
- Charge
- 0
- InChIKey
- WHBHBVVOGNECLV-OBQKJFGGSA-N
- SMILES
- [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
9 statements
9 statements · 2 reference databases · Subject: 11-deoxycortisol · Sources: Human-GEM, Rhea
- 17alpha-hydroxyprogesterone is converted to 11-deoxycortisolCompoundHuman-GEM MAR07928Inferred only
- 17alpha-hydroxyprogesterone is converted to 11-deoxycortisolCompoundHuman-GEM MAR01988Inferred only
- 17alpha,21-dihydroxypregnenolone is converted to 11-deoxycortisolCompoundHuman-GEM MAR01949Inferred only
- 11-deoxycortisol is converted to cortisolCompoundHuman-GEM MAR01995Inferred only
- 11-deoxycortisol is metabolised by CYP11B1ProteinHuman-GEM MAR01995Inferred only
- 11-deoxycortisol is metabolised by CYP11B1ProteinRhea RHEA:46100Inferred only
- 11-deoxycortisol is metabolised by CYP11B2ProteinHuman-GEM MAR01995Inferred only
- 11-deoxycortisol is metabolised by CYP11B2ProteinRhea RHEA:46100Inferred only
- 11-deoxycortisol is transported by ABCB1ProteinHuman-GEM MAR11766Inferred only
Reactions
12 reactions
17alpha,21-dihydroxypregnenolone+NAD(+)11-deoxycortisol+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.145, 5.3.3.1cytosol
Human-GEM MAR01949CC BY 4.0Reference data
17alpha-hydroxyprogesterone+proton+NADPH(4-)+dioxygen11-deoxycortisol+water+NADP(3-)
Catalysed by CYP21A2
Reaction pageLeft to rightBalancedEC 1.14.14.16cytosol
Human-GEM MAR01988CC BY 4.0Reference data
11-deoxycortisol11-deoxycortisol
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR01994CC BY 4.0Reference data
11-deoxycortisol+proton+NADPH(4-)+dioxygencortisol+water+NADP(3-)
Catalysed by CYP11B1 or CYP11B2
Reaction pageLeft to rightBalancedEC 1.14.15.4mitochondrial matrix
Human-GEM MAR01995CC BY 4.0Reference data
17alpha-hydroxyprogesterone+proton+NADPH(4-)+dioxygen11-deoxycortisol+water+NADP(3-)
Catalysed by CYP21A2
Reaction pageLeft to rightBalancedEC 1.14.14.16endoplasmic reticulum
Human-GEM MAR07928CC BY 4.0Reference data
11-deoxycortisol11-deoxycortisol
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07929CC BY 4.0Reference data
11-deoxycortisol+ATP+water11-deoxycortisol+ADP+proton+phosphate(3-)
Transported by ABCB1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11766CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11865CC BY 4.0Reference data
11-deoxycortisol+2reduced [adrenodoxin]+dioxygen+2hydroncortisol+2oxidized [adrenodoxin]+water
Catalysed by CYP11B1 or CYP11B2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46100CC BY 4.0Reference data
17alpha-hydroxyprogesterone+reduced [NADPH--hemoprotein reductase]+dioxygen11-deoxycortisol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP21A2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50308CC BY 4.0Reference data
11-deoxycortisol+2reduced [adrenodoxin]+dioxygen+2hydronCHEBI:195179+2oxidized [adrenodoxin]+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:76163CC BY 4.0Reference data
CHEBI:235407+NAD(1-)11-deoxycortisol+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:86115CC BY 4.0Reference data
Where it reaches
3 systems, 6 regions, 11 tissues, 11 transporter routes — routes, not measurements: transporters known to carry 11-deoxycortisol are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: 11-deoxycortisol
- Also called
- 11-desoxy-17-hydroxycorticosteroneCortodoxoneST 21:3;O4
- Systematic name
- 17,21-dihydroxypregn-4-ene-3,20-dione