Compound
butyric acid
A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
Definition from ChEBI (CHEBI:30772), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
18 entities
18 entities reached.
0 reported hops18 assembled from the scaffold
- SLC16A1ProteinUNIPROT:P53985transported byInferred only200 paths25 endpoints
- FABP5ProteinUNIPROT:Q01469transported byInferred only101 paths93 endpoints
- CD36ProteinUNIPROT:P16671transported byInferred only82 paths77 endpoints
- SLC16A7ProteinUNIPROT:O60669transported byInferred only42 paths6 endpoints
- SLC16A3ProteinUNIPROT:O15427transported byInferred only21 paths7 endpoints
- ACSM1ProteinUNIPROT:Q08AH1substrate ofInferred only16 paths8 endpoints
- ACSM2BProteinUNIPROT:Q68CK6substrate ofInferred only10 paths10 endpoints
- FABP3ProteinUNIPROT:P05413transported byInferred only9 paths9 endpoints
- ACSM2AProteinUNIPROT:Q08AH3substrate ofInferred only8 paths8 endpoints
- ACSM5ProteinUNIPROT:Q6NUN0substrate ofInferred only8 paths8 endpoints
- ACSM4ProteinUNIPROT:P0C7M7substrate ofInferred only8 paths8 endpoints
- ACSM3ProteinUNIPROT:Q53FZ2substrate ofInferred only6 paths6 endpoints
Show the remaining 6
- FABP4ProteinUNIPROT:P15090transported byInferred only6 paths6 endpoints
- SLC27A6ProteinUNIPROT:Q9Y2P4transported byInferred only4 paths4 endpoints
- SLC16A8ProteinUNIPROT:O95907transported byInferred only4 paths1 endpoint
- FABP1ProteinUNIPROT:P07148transported byInferred only3 paths3 endpoints
- SLC27A4ProteinUNIPROT:Q6P1M0transported byInferred only2 paths2 endpoints
- FABP2ProteinUNIPROT:P12104transported byInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine has the functional parent butyric acidCompoundChEBI CHEBI:77832Inferred only
- 1,2,3-tributanoylglycerol has the functional parent butyric acidCompoundChEBI CHEBI:35020Inferred only
- 2-hydroxybutyric acid has the functional parent butyric acidCompoundChEBI CHEBI:1148Inferred only
- 3-hydroxyisovaleric acid has the functional parent butyric acidCompoundChEBI CHEBI:37084Inferred only
- 4-methylthio-2-oxobutanoic acid has the functional parent butyric acidCompoundChEBI CHEBI:33574Inferred only
- a butanoate ester has the functional parent butyric acidCompoundChEBI CHEBI:50477Inferred only
- dibutanoylglycerol has the functional parent butyric acidCompoundChEBI CHEBI:76478Inferred only
Statements
63 statements
63 statements · 1 reference database · Subject: butyric acid · Sources: Human-GEM
- butyric acid is a substrate of ACSM1ProteinHuman-GEM MAR00156Inferred only
- butyric acid is a substrate of ACSM1ProteinHuman-GEM MAR00742Inferred only
- butyric acid is a substrate of ACSM2AProteinHuman-GEM MAR00156Inferred only
- butyric acid is a substrate of ACSM2BProteinHuman-GEM MAR00156Inferred only
- butyric acid is a substrate of ACSM3ProteinHuman-GEM MAR00156Inferred only
- butyric acid is a substrate of ACSM4ProteinHuman-GEM MAR00156Inferred only
- butyric acid is a substrate of ACSM5ProteinHuman-GEM MAR00156Inferred only
- butyric acid is transported by CD36ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP1ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP12ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP2ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP3ProteinHuman-GEM MAR00155Inferred only
Show the remaining 51
- butyric acid is transported by FABP4ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP5ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP6ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP7ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by FABP9ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR06019Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR06048Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR11396Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR00097Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR06046Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR06043Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR06034Inferred only
- butyric acid is transported by SLC16A1ProteinHuman-GEM MAR06027Inferred only
- butyric acid is transported by SLC16A3ProteinHuman-GEM MAR06019Inferred only
- butyric acid is transported by SLC16A3ProteinHuman-GEM MAR06052Inferred only
- butyric acid is transported by SLC16A3ProteinHuman-GEM MAR06048Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06012Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06048Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06019Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06027Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06034Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06039Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06043Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06046Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06051Inferred only
- butyric acid is transported by SLC16A4ProteinHuman-GEM MAR06052Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06046Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06048Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06019Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06012Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06027Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06034Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06052Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06039Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06051Inferred only
- butyric acid is transported by SLC16A5ProteinHuman-GEM MAR06043Inferred only
- butyric acid is transported by SLC16A7ProteinHuman-GEM MAR06048Inferred only
- butyric acid is transported by SLC16A7ProteinHuman-GEM MAR06034Inferred only
- butyric acid is transported by SLC16A7ProteinHuman-GEM MAR06012Inferred only
- butyric acid is transported by SLC16A7ProteinHuman-GEM MAR06046Inferred only
- butyric acid is transported by SLC16A7ProteinHuman-GEM MAR06043Inferred only
- butyric acid is transported by SLC16A7ProteinHuman-GEM MAR06019Inferred only
- butyric acid is transported by SLC16A7ProteinHuman-GEM MAR06052Inferred only
- butyric acid is transported by SLC16A8ProteinHuman-GEM MAR06012Inferred only
- butyric acid is transported by SLC16A8ProteinHuman-GEM MAR06046Inferred only
- butyric acid is transported by SLC16A8ProteinHuman-GEM MAR06019Inferred only
- butyric acid is transported by SLC16A8ProteinHuman-GEM MAR06048Inferred only
- butyric acid is transported by SLC27A1ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by SLC27A4ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by SLC27A6ProteinHuman-GEM MAR00155Inferred only
- butyric acid is transported by SLC5A8ProteinHuman-GEM MAR09874Inferred only
Reactions
19 reactions
MAM02909e0.125butyric acid+0.125decanoate+0.125heptanoate+0.125MAM02120e+0.125nonanoate+0.125octanoate+0.125MAM03117e+0.125pentanoate
Reaction pageLeft to rightBalance undeterminableextracellular space
Human-GEM MAR00017CC BY 4.0Reference data
butyric acid+protonbutyric acid+proton
Transported by SLC16A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00097CC BY 4.0Reference data
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 or FABP12 and 1 more alternative
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00155CC BY 4.0Reference data
ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00156CC BY 4.0Reference data
ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM1
Reaction pageLeft to rightBalancedEC 6.2.1.2mitochondrial matrix
Human-GEM MAR00742CC BY 4.0Reference data
2-hydroxybutyric acid+butyric acid2-hydroxybutyric acid+butyric acid
Transported by SLC16A8 or SLC16A7 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06012CC BY 4.0Reference data
butyric acid+pyruvatebutyric acid+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06019CC BY 4.0Reference data
2-oxoglutarate(2-)+butyric acid2-oxoglutarate(2-)+butyric acid
Transported by SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06027CC BY 4.0Reference data
acetate+butyric acidacetate+butyric acid
Transported by SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06034CC BY 4.0Reference data
butyric acid+formic acidbutyric acid+formic acid
Transported by SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06039CC BY 4.0Reference data
butyric acid+propionic acidbutyric acid+propionic acid
Transported by SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06043CC BY 4.0Reference data
acetoacetate+butyric acidacetoacetate+butyric acid
Transported by SLC16A8 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06046CC BY 4.0Reference data
On the label
Labelled products
22 products
Source: NIH DSLD · Ingredient: butyric acid · 22 products · Declared amount per serving: 100–1,500 mg (16 products)
19 labels state an amount3 do not
- Allergy Research GroupButyrEnCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, and Magnesium Butyrate)200 mgper 1 Capsule(s)DSLD:258057
- Allergy Research GroupButyrENCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, and Magnesium Butyrate)200 mgper 1 Capsule(s)DSLD:258058
- Biotics Research CorporationButyric-Cal-MagCalcium Butyrate · Butyric Acid (Form: as calcium {butyrate}, and magnesium butyrate)1,033 mgper 1 Capsule(s)DSLD:21531
- Douglas LaboratoriesMCT/Butyrate Liquidproviding5 Gram(s)per 15 mLDSLD:286497
- Ecological FormulasButyric AcidCalcium Butyrate250 mgper 1 Capsule(s)DSLD:271205
- Enzyme ScienceGI + Biome Complex200 mgper 2 Capsule(s)DSLD:334825
- Genestra BrandsButyrate ComplexCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, Magnesium Butyrate)460 mgper 1 Capsule(s)DSLD:218081
- Genestra BrandsPEA GI SupportCalcium Butyrate100 mgper 3 Capsule(s)DSLD:267731
- Genestra BrandsSunButyrate Liquid Natural Blueberry-Vanilla Flavor875 mgper 5 mLDSLD:241156
- GNC Mega MenUltra Testosterone1,500 mgper 4 Capsule(s)DSLD:308324
- GNC Mega MenUltra Testosterone1,500 mgper 4 Capsule(s)DSLD:315853
- InessaBiosootheSodium Butyrate100 mgper 2 Capsule(s)DSLD:318802
Show the remaining 10
- NutriCologyButyrAidCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, and Magnesium Butyrate)200 mgper 1 Capsule(s)DSLD:234801
- NutriCologyButyrAidCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, and Magnesium Butyrate)200 mgper 1 Capsule(s)DSLD:234802
- PharmaxHLC Colon-IzerCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, & Magnesium Butyrate)2.5 Gram(s)per 6 Gram(s)DSLD:55794
- Pure EncapsulationsSunButyrate-TG Liquid Natural Blueberry-Vanilla Flavor4.5 Gram(s)per 1 Teaspoon(s)DSLD:294057
- Renew LifePara ZymeCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, & Magnesium Butyrate)amount not statedper 1 Capsule(s)DSLD:178516
- Renew LifePara Zyme TargetedCalcium Butyrate · Butyric Acid (Form: as Calcium Butyrate, & Magnesium Butyrate)amount not statedper 1 Capsule(s)DSLD:243328
- Systemic Formulas Bio ChallengeLGLUT Leaky Gut Masteryamount not statedper 1 Capsule(s)DSLD:22181
- Tesseract Medical ResearchProButyrateComplex300 mgper 1 Capsule(s)DSLD:259134
- Tesseract Medical ResearchProButyrateStabilized Butyric acid as soluble, pure, individual free fatty acid in hexadextrin matrix molecular trap compound with DexKey release agent (patend pending, Al Czap, Czap R7D, licensed by Tesseract Medical Research, LLC).300 mgper 1 Capsule(s)DSLD:307067
- Tesseract Medical ResearchProButyrateStabilized natural butyric acid as soluble, pure, individual free fatty acid in in CyLoc, a dextrin fiber matrix molecular trap.600 mgper 2 Capsule(s)DSLD:328494
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
10 systems, 27 regions, 131 tissues, 181 transporter routes — routes, not measurements: transporters known to carry butyric acid are expressed there, and no source reports it arriving.
Loading the model…
Other names
16 names
Resolves to: butyric acid
- Also called
- 1-butanoic acid1-butyric acid1-propanecarboxylic acid4:0butanic acidButanoateButanoic acidbutoic acidC4:0CH3-[CH2]2-COOHCH3‒[CH2]2‒COOHethylacetic acidn-butanoic acidn-butyric acidpropanecarboxylic acidpropylformic acid