Compound
5-methyltetrahydrofolic acid
A tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5.
Definition from ChEBI (CHEBI:15641), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Chemical structure
- 5-methyltetrahydrofolic acid has the functional parent 5,6,7,8-tetrahydrofolic acidCompoundChEBI CHEBI:15641Inferred only
Statements
8 statements
8 statements · 1 reference database · Subject: 5-methyltetrahydrofolic acid · Sources: Human-GEM
- (6R)-5,10-methylenetetrahydrofolic acid is converted to 5-methyltetrahydrofolic acidCompoundHuman-GEM MAR04448Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is converted to 5-methyltetrahydrofolic acidCompoundHuman-GEM MAR04446Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 5-methyltetrahydrofolic acidCompoundHuman-GEM MAR03915Inferred only
- 5-methyltetrahydrofolic acid is a substrate of MTRProteinHuman-GEM MAR03917Inferred only
- 5-methyltetrahydrofolic acid is transported by FOLR1ProteinHuman-GEM MAR03916Inferred only
- 5-methyltetrahydrofolic acid is transported by FOLR3ProteinHuman-GEM MAR03916Inferred only
- 5-methyltetrahydrofolic acid is transported by SLC19A1ProteinHuman-GEM MAR00053Inferred only
- 5-methyltetrahydrofolic acid is transported by SLC19A1ProteinHuman-GEM MAR07683Inferred only
Reactions
11 reactions
5-methyltetrahydrofolic acid+water5-methyltetrahydrofolic acid+water
Transported by SLC19A1
Reaction pageReversibleBalancedGO:0005615, GO:0005829
Human-GEM MAR00053CC BY 4.0Reference data
S-adenosyl-L-methionine+5,6,7,8-tetrahydrofolic acid5-methyltetrahydrofolic acid+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedEC 2.1.1.8GO:0005829
Human-GEM MAR03915CC BY 4.0Reference data
5-methyltetrahydrofolic acid5-methyltetrahydrofolic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR03916CC BY 4.0Reference data
5-methyltetrahydrofolic acid+homocysteineproton+L-methionine+5,6,7,8-tetrahydrofolic acid
Catalysed by MTR
Reaction pageLeft to rightBalancedEC 2.1.1.13GO:0005829
Human-GEM MAR03917CC BY 4.0Reference data
5-methyltetrahydrofolic acid+Se-methylselenocysteineproton+selenomethionine+5,6,7,8-tetrahydrofolic acid
Reaction pageLeft to rightBalancedEC 2.1.1.13GO:0005634
Human-GEM MAR04011CC BY 4.0Reference data
5-methyltetrahydrofolic acid+Se-methylselenocysteineproton+selenomethionine+5,6,7,8-tetrahydrofolic acid
Reaction pageLeft to rightBalancedEC 2.1.1.13GO:0005783
Human-GEM MAR04013CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+2proton+NADPH(4-)5-methyltetrahydrofolic acid+NADP(3-)
Catalysed by MTHFR
Reaction pageLeft to rightBalancedEC 1.5.1.20GO:0005829
Human-GEM MAR04446CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+2proton+NADH(2-)5-methyltetrahydrofolic acid+NAD(+)
Catalysed by MTHFR
Reaction pageLeft to rightBalancedEC 1.5.1.20GO:0005829
Human-GEM MAR04448CC BY 4.0Reference data
5-methyltetrahydrofolic acid+water5-methyltetrahydrofolic acid+water
Transported by SLC19A1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR07683CC BY 4.0Reference data
5-methyltetrahydrofolic acid+MAM01698c(6R)-5,10-methylenetetrahydrofolic acid+proton+5,6,7,8-tetrahydrobiopterin
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR08740CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09234CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry 5-methyltetrahydrofolic acid are expressed there, and no source reports it arriving.
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Other names
16 names
Resolves to: 5-methyltetrahydrofolic acid
- Also called
- 5-methyl-5,6,7,8-tetrahydrofolate5-methyl-5,6,7,8-tetrahydrofolic acid5-methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid5-methyl-THF5-methyltetrahydrofolate5-methyltetrahydropteroylglutamic acidN-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acidN-methyltetrahydrofolateN-methyltetrahydrofolic acidN(5)-methyl-tetrahydrofolateN(5)-methyl-tetrahydrofolic acidN(5)-methyltetrahydrofolic acidN5-methyl-tetrahydrofolateN5-methyl-tetrahydrofolic acidN5-methyltetrahydrofolic acid
- Systematic name
- N-(4-{[(2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid