Compound
CHEBI:15650
A biologically active principle of srs-a that is formed from leukotriene D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)
What it touches on the way
Mechanistic reach
29 entities
29 entities reached.
0 reported hops29 assembled from the scaffold
- ZDHHC8ProteinUNIPROT:Q9ULC8substrate ofInferred only26 paths13 endpoints
- ZDHHC9ProteinUNIPROT:Q9Y397substrate ofInferred only26 paths13 endpoints
- LPCAT1ProteinUNIPROT:Q8NF37substrate ofInferred only24 paths12 endpoints
- ZDHHC2ProteinUNIPROT:Q9UIJ5substrate ofInferred only20 paths10 endpoints
- ZDHHC3ProteinUNIPROT:Q9NYG2substrate ofInferred only18 paths9 endpoints
- ZDHHC11ProteinUNIPROT:Q9H8X9substrate ofInferred only16 paths8 endpoints
- NAA10ProteinUNIPROT:P41227substrate ofInferred only14 paths7 endpoints
- ZDHHC21ProteinUNIPROT:Q8IVQ6substrate ofInferred only14 paths7 endpoints
- PORCNProteinUNIPROT:Q9H237substrate ofInferred only14 paths14 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only12 paths2 endpoints
- ESCO1ProteinUNIPROT:Q5FWF5substrate ofInferred only10 paths5 endpoints
- LPCAT2ProteinUNIPROT:Q7L5N7substrate ofInferred only10 paths5 endpoints
Show the remaining 17
- PLAAT2ProteinUNIPROT:Q9NWW9substrate ofInferred only10 paths5 endpoints
- SH3GLB1ProteinUNIPROT:Q9Y371substrate ofInferred only10 paths4 endpoints
- LPCAT3ProteinUNIPROT:Q6P1A2substrate ofInferred only8 paths8 endpoints
- LCLAT1ProteinUNIPROT:Q6UWP7substrate ofInferred only8 paths8 endpoints
- ZDHHC5ProteinUNIPROT:Q9C0B5substrate ofInferred only8 paths8 endpoints
- ZDHHC7ProteinUNIPROT:Q9NXF8substrate ofInferred only8 paths4 endpoints
- MBOAT1ProteinUNIPROT:Q6ZNC8substrate ofInferred only7 paths7 endpoints
- MBOAT7ProteinUNIPROT:Q96N66substrate ofInferred only7 paths7 endpoints
- MBOAT2ProteinUNIPROT:Q6ZWT7substrate ofInferred only6 paths6 endpoints
- ESCO2ProteinUNIPROT:Q56NI9substrate ofInferred only5 paths5 endpoints
- PLA2G15ProteinUNIPROT:Q8NCC3substrate ofInferred only5 paths5 endpoints
- NAT9ProteinUNIPROT:Q9BTE0substrate ofInferred only4 paths4 endpoints
- MBOAT4ProteinUNIPROT:Q96T53substrate ofInferred only3 paths3 endpoints
- NAT8ProteinUNIPROT:Q9UHE5substrate ofInferred only3 paths3 endpoints
- NAA40ProteinUNIPROT:Q86UY6substrate ofInferred only1 path1 endpoint
- ZDHHC19ProteinUNIPROT:Q8WVZ1substrate ofInferred only1 path1 endpoint
- NAA80ProteinUNIPROT:Q93015substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
76 statements
76 statements · 1 reference database · Subject: CHEBI:15650 · Sources: Human-GEM
- CHEBI:15650 is converted to CHEBI:1146900CompoundHuman-GEM MAR01091Inferred only
- CHEBI:15650 is converted to CHEBI:1146900CompoundHuman-GEM MAR01088Inferred only
- CHEBI:1146900 is converted to CHEBI:15650CompoundHuman-GEM MAR01088Inferred only
- CHEBI:1146900 is converted to CHEBI:15650CompoundHuman-GEM MAR01091Inferred only
- CHEBI:15650 is converted to leukotriene F4CompoundHuman-GEM MAR08549Inferred only
- leukotriene F4 is converted to CHEBI:15650CompoundHuman-GEM MAR08549Inferred only
- CHEBI:15650 is a substrate of ESCO1ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ESCO1ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ESCO2ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of LCLAT1ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of LPCAT1ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of LPCAT1ProteinHuman-GEM MAR01091Inferred only
Show the remaining 64
- CHEBI:15650 is a substrate of LPCAT2ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of LPCAT2ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of LPCAT3ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of MBOAT1ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of MBOAT2ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of MBOAT4ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of MBOAT7ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of NAA10ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of NAA10ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of NAA40ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of NAA60ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of NAA60ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of NAA80ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of NAT14ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of NAT14ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of NAT16ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of NAT16ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of NAT8ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of NAT9ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of PLA2G15ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of PLAAT2ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of PLAAT2ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of PORCNProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of SATL1ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of SATL1ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of SH3GLB1ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of SH3GLB1ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC1ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC1ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC11ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC11ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC11BProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC11BProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC12ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC13ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC13ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC14ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC14ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC15ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC15ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC17ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC19ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC2ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC2ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC21ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC21ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC22ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC24ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC3ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC3ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC4ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC5ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC6ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC7ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC7ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC8ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is a substrate of ZDHHC8ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC9ProteinHuman-GEM MAR01088Inferred only
- CHEBI:15650 is a substrate of ZDHHC9ProteinHuman-GEM MAR01091Inferred only
- CHEBI:15650 is transported by SLC22A10ProteinHuman-GEM MAR01086Inferred only
- CHEBI:15650 is transported by SLCO1B1ProteinHuman-GEM MAR06154Inferred only
- CHEBI:15650 is transported by SLCO1B1ProteinHuman-GEM MAR06156Inferred only
- CHEBI:15650 is transported by SLCO1B1ProteinHuman-GEM MAR06106Inferred only
- CHEBI:15650 is transported by SLCO1B1ProteinHuman-GEM MAR06155Inferred only
Reactions
15 reactions
water+CHEBI:28666glycine+CHEBI:15650
Reaction pageLeft to rightBalancedEC 3.4.13.19GO:0005615
Human-GEM MAR01085CC BY 4.0Reference data
Transported by SLC22A10
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR01086CC BY 4.0Reference data
proton+CHEBI:15650MAM00304c
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR01087CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-GO:0005829
Human-GEM MAR01088CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005829, GO:0005634
Human-GEM MAR01089CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-GO:0005634
Human-GEM MAR01091CC BY 4.0Reference data
Reaction pageLeft to rightBalancedGO:0005829, GO:0005777
Human-GEM MAR01286CC BY 4.0Reference data
proton+CHEBI:15650+NADPH(4-)+dioxygenMAM00596x+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.13.34GO:0005777
Human-GEM MAR01287CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+CHEBI:15650CHEBI:16856+hydrogencarbonate+CHEBI:15650
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06106CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+CHEBI:15650MAM01980e+hydrogencarbonate+CHEBI:15650
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR06154CC BY 4.0Reference data
hydrogencarbonate+CHEBI:15650+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+CHEBI:15650+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06155CC BY 4.0Reference data
hydrogencarbonate+CHEBI:15650+MAM02901chydrogencarbonate+CHEBI:15650+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06156CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 2 tissues, 2 transporter routes — routes, not measurements: transporters known to carry CHEBI:15650 are expressed there, and no source reports it arriving.
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Other names
8 names
Resolves to: CHEBI:15650
- Also called
- (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acidLeukotriene E4LTE4
- Systematic name
- (5S,6R,7E,9E,11Z,14Z)-6-(L-cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoic acidS-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine