Compound
steviol glycoside
A diterpene glycoside derived from steviol by formal esterification of the carboxy group with glucose (or a glucose derivative) and glycosylation of the tertiary hydroxy group with combinations of glucose and rhamnose to give the corresponding glycosides.
Definition from ChEBI (CHEBI:145027), read 2026-09-23. CC BY 4.0.
What the evidence says
How to read these marks1 finding · 1 endpoint · 1 paper · 1 null · by evidence strength
Every finding here is a null result.
What did not
1 finding
No detected effect on systolic blood pressure (setting unspecified)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Meta-analysis revealed a non-significant difference in systolic blood pressure between steviol glycoside and placebo, mean difference (MD): -2.98 mm Hg (-6.23 to 0.27).”
Quoted verbatim from Effect of the natural sweetener, steviol glycoside, on cardiovascular risk factors: a systematic review and meta-analysis of randomised clinical trials.. - Study
- meta-analysis
- Population
- Participants in nine randomised trials of stevioside or rebaudioside A (756 participants overall), most at high cardiovascular risk
Effect -2.98 mean difference, 95% CI -6.23 to 0.27
Effect of the natural sweetener, steviol glycoside, on cardiovascular risk factors: a systematic review and meta-analysis of randomised clinical trials.2015PMID:25412840Permalink
On the label
Labelled products
2 products
Source: NIH DSLD · Ingredient: steviol glycoside · 2 products · Declared amount per serving: 34–36 mg (2 products)
2 labels state an amount0 do not
- Trace MineralsMagnesium Effervescent Tablets OrangeStevia36 mgper 1 Tablet(s)DSLD:293857
- Trace MineralsMagnesium Effervescent Tablets RaspberryStevia34 mgper 1 Tablet(s)DSLD:293858
Label record: NIH Office of Dietary Supplements · CC0
Papers screened
4 papers
- Compound
- steviol glycoside
- Screened
- 4
- Admitted
- 1
- Discarded
- 3
- Not read
- 0
Produced a finding1 paper
- PMID:254128402026-10-12
Discarded: the wrong intervention3 papers
- NCT02411565intervention×1 — no declared intervention names steviol glycoside2026-09-21
- NCT04421014intervention×1 — no declared intervention names steviol glycoside2026-09-21
- NCT04847999intervention×1 — no declared intervention names steviol glycoside2026-09-21
Measured, not recorded
- Compound
- steviol glycoside
- Endpoints measured
- 12 endpoints
- Recorded as a finding
- No
Show what was measured
fasting blood glucose
decreases
Significant reductions in diastolic blood pressure and fasting blood glucose were observed
PMID:25412840 · one of two readings recorded this
blood lipid profile, pooled across trials, individual lipids not named
no effect
Not recorded as a finding: No single lipid node matches a composite lipid profile; sentence is agentless
There was no significant effect on blood lipid profile.
PMID:25412840 · one of two readings recorded this
blood lipid profile, pooled
no effect
Not recorded as a finding: No outcome node for the unspecified lipid profile; sentence is agentless and does not name the compound
There was no significant effect on blood lipid profile.
PMID:25412840 · one of two readings recorded this
blood lipid profile
no effect
There was no significant effect on blood lipid profile
PMID:25412840 · one of two readings recorded this
blood pressure and cardiovascular risk factors
no effect
Rebaudioside A does not appear to have any significant effects on blood pressure or cardiovascular risk factors
PMID:25412840 · one of two readings recorded this
blood pressure and fasting blood glucose
decreases
The evidence from published RCTs suggests that stevioside may generate reductions in blood pressure and fasting blood glucose
PMID:25412840 · one of two readings recorded this
diastolic blood pressure, pooled across trials, instrument not stated
decreases
Not recorded as a finding: Only sentence is agentless (does not name the compound) and gives no estimate; stevioside-specific hedged conclusion elsewhere
Significant reductions in diastolic blood pressure and fasting blood glucose were observed.
PMID:25412840 · one of two readings recorded this
diastolic blood pressure, pooled mean difference vs placebo (instrument not stated)
decreases
Not recorded as a finding: Only sentence is agentless and does not name the compound; no estimate in the abstract
Significant reductions in diastolic blood pressure and fasting blood glucose were observed.
PMID:25412840 · one of two readings recorded this
diastolic blood pressure
decreases
Significant reductions in diastolic blood pressure and fasting blood glucose were observed
PMID:25412840 · one of two readings recorded this
fasting blood glucose, pooled across trials, assay not stated
decreases
Not recorded as a finding: Only sentence is agentless (does not name the compound) and gives no estimate; shares one sentence with diastolic blood pressure
Significant reductions in diastolic blood pressure and fasting blood glucose were observed.
PMID:25412840 · one of two readings recorded this
fasting blood glucose, pooled vs placebo
decreases
Not recorded as a finding: Only sentence is agentless and does not name the compound; no estimate in the abstract
Significant reductions in diastolic blood pressure and fasting blood glucose were observed.
PMID:25412840 · one of two readings recorded this
systolic blood pressure
no effect
Meta-analysis revealed a non-significant difference in systolic blood pressure between steviol glycoside and placebo, mean difference (MD): -2.98 mm Hg (-6.23 to 0.27)
PMID:25412840 · one of two readings recorded this
Sources cited
1 paper
- Subject
- steviol glycoside
- Findings
- 1
- Papers
- 1
Other names
1 name
Resolves to: steviol glycoside
- Also called
- steviol glycosides