Compound
CHEBI:28918
The active sympathomimetic hormone from the adrenal medulla. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics.
What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- MAOAProteinUNIPROT:P21397metabolized byInferred only36 paths36 endpoints
- COMTProteinUNIPROT:P21964metabolized byInferred only35 paths35 endpoints
- SLC18A2ProteinUNIPROT:Q05940transported byInferred only14 paths7 endpoints
- MAOBProteinUNIPROT:P27338metabolized byInferred only13 paths13 endpoints
- SLC18A1ProteinUNIPROT:P54219transported byInferred only12 paths6 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only5 paths5 endpoints
- SLC22A1ProteinUNIPROT:O15245transported byInferred only3 paths3 endpoints
- SLC29A4ProteinUNIPROT:Q7RTT9transported byInferred only1 path1 endpoint
What the reference databases state
Statements
14 statements
14 statements · 1 reference database · Subject: CHEBI:28918 · Sources: Human-GEM
- (R)-noradrenaline is converted to CHEBI:28918CompoundHuman-GEM MAR06743Inferred only
- CHEBI:28918 is converted to methylamineCompoundHuman-GEM MAR06745Inferred only
- CHEBI:28918 is converted to N(2)-[4-(indol-3-yl)butanoyl]-L-glutamineCompoundHuman-GEM MAR06746Inferred only
- CHEBI:28918 is metabolised by COMTProteinHuman-GEM MAR06746Inferred only
- CHEBI:28918 is metabolised by MAOAProteinHuman-GEM MAR06745Inferred only
- CHEBI:28918 is metabolised by MAOBProteinHuman-GEM MAR06745Inferred only
- CHEBI:28918 is a substrate of LRTOMTProteinHuman-GEM MAR06746Inferred only
- CHEBI:28918 is transported by SLC18A1ProteinHuman-GEM MAR07635Inferred only
- CHEBI:28918 is transported by SLC18A1ProteinHuman-GEM MAR00065Inferred only
- CHEBI:28918 is transported by SLC18A2ProteinHuman-GEM MAR00065Inferred only
- CHEBI:28918 is transported by SLC18A2ProteinHuman-GEM MAR07635Inferred only
- CHEBI:28918 is transported by SLC22A1ProteinHuman-GEM MAR09192Inferred only
Show the remaining 2
- CHEBI:28918 is transported by SLC22A2ProteinHuman-GEM MAR09192Inferred only
- CHEBI:28918 is transported by SLC29A4ProteinHuman-GEM MAR09192Inferred only
Reactions
9 reactions
CHEBI:28918+ATP+waterADP+CHEBI:28918+proton+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR00065CC BY 4.0Reference data
(R)-noradrenaline+S-adenosyl-L-methionineCHEBI:28918+proton+CHEBI:16680
Catalysed by PNMT
Reaction pageLeft to rightBalancedEC 2.1.1.28GO:0005829
Human-GEM MAR06743CC BY 4.0Reference data
proton+water+MAM02599cCHEBI:28918+formaldehyde
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR06744CC BY 4.0Reference data
CHEBI:28918+water+dioxygenMAM00726c+hydrogen peroxide+methylamine
Reaction pageLeft to rightBalancedEC 1.4.3.4GO:0005829
Human-GEM MAR06745CC BY 4.0Reference data
CHEBI:28918+S-adenosyl-L-methionineproton+N(2)-[4-(indol-3-yl)butanoyl]-L-glutamine+CHEBI:16680
Reaction pageLeft to rightBalancedEC 2.1.1.6GO:0005829
Human-GEM MAR06746CC BY 4.0Reference data
CHEBI:28918+dioxygenMAM01292c+proton+2water
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR06818CC BY 4.0Reference data
3CHEBI:28918+2ATP+2water2ADP+3CHEBI:28918+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR07635CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09095CC BY 4.0Reference data
Transported by SLC22A2 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR09192CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 13 tissues, 14 transporter routes — routes, not measurements: transporters known to carry CHEBI:28918 are expressed there, and no source reports it arriving.
Loading the model…
Other names
21 names
Resolves to: CHEBI:28918
- Also called
- (-)-(R)-epinephrine(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol(-)-adrenaline(−)-(R)-epinephrine(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol(−)-adrenaline(R)-(-)-Adnephrine(R)-(-)-Adrenaline(R)-(-)-Epinephrine(R)-(-)-Epirenamine(R)-(−)-adrenaline4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenedioladrenalineepinephrineL-Adrenalinelevoepinephrine
- Systematic name
- 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
- Sold as
- AdrenalinEpipenEpipen JRPrimatene