Compound
spermine
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
Structure
Loading the model…
- Class
- Organic compound, cation
- Formula
- C10H30N4
- Mass
- 206.378 g/mol
- Charge
- +4
- InChIKey
- PFNFFQXMRSDOHW-UHFFFAOYSA-R
- SMILES
- [NH3+]CCC[NH2+]CCCC[NH2+]CCC[NH3+]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Chemical structure
- spermine monoaldehyde has the functional parent spermineCompoundChEBI CHEBI:180903Inferred only
Statements
8 statements
8 statements · 1 reference database · Subject: spermine · Sources: Rhea
- spermine is converted to N(1)-acetylspermineCompoundRhea RHEA:33099Inferred only
- spermine is converted to spermine monoaldehydeCompoundRhea RHEA:69148Inferred only
- spermine monoaldehyde is converted to spermineCompoundRhea RHEA:69148Inferred only
- spermine is a substrate of SAT1ProteinRhea RHEA:33099Inferred only
- spermine is a substrate of SMOXProteinRhea RHEA:25804Inferred only
- spermine is transported by ATP13A2ProteinRhea RHEA:63368Inferred only
- spermine is transported by ATP13A4ProteinRhea RHEA:63368Inferred only
- spermine is transported by SLC18B1ProteinRhea RHEA:74263Inferred only
Reactions
11 reactions
S-adenosyl 3-(methylsulfanyl)propylamine+spermidinespermine+S-methyl-5'-thioadenosine+hydron
Catalysed by SMS
Reaction pageLeft to rightBalanced
Rhea RHEA:19973CC BY 4.0Reference data
spermine+dioxygen+water3-aminopropanal+spermidine+hydrogen peroxide
Catalysed by SMOX
Reaction pageDirection not assertedBalanced
Rhea RHEA:25804CC BY 4.0Reference data
spermine+dioxygen+waterCHEBI:58869+propane-1,3-diamine+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:25824CC BY 4.0Reference data
spermine+acetyl-CoAN(1)-acetylspermine+coenzyme A(4-)+hydron
Catalysed by SAT1
Reaction pageLeft to rightBalanced
Rhea RHEA:33099CC BY 4.0Reference data
spermine+S-adenosyl 3-(methylsulfanyl)propylamineCHEBI:82772+S-methyl-5'-thioadenosine+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:42880CC BY 4.0Reference data
N(1)-acetylspermine+waterspermine+acetate
Reaction pageDirection not assertedBalanced
Rhea RHEA:51896CC BY 4.0Reference data
spermine+ATP(4-)+waterspermine+ADP(3-)+hydrogenphosphate+hydron
Transported by ATP13A4 or ATP13A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:63368CC BY 4.0Reference data
spermine+2dioxygen+2waterCHEBI:180902+2hydrogen peroxide+2ammonium
Reaction pageDirection not assertedBalanced
Rhea RHEA:69136CC BY 4.0Reference data
spermine+dioxygen+waterspermine monoaldehyde+hydrogen peroxide+ammonium
Reaction pageDirection not assertedBalanced
Rhea RHEA:69148CC BY 4.0Reference data
spermine+L-glutamate(1-)+ATP(4-)CHEBI:193052+ADP(3-)+hydrogenphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:73895CC BY 4.0Reference data
spermine+nhydronspermine+nhydron
Transported by SLC18B1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:74263CC BY 4.0Reference data
Where it reaches
10 systems, 20 regions, 56 tissues, 57 transporter routes — routes, not measurements: transporters known to carry spermine are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: spermine
- Also called
- SPERMINE (FULLY PROTONATED FORM)spermine (fully protonated)
- Systematic name
- N,N'-bis(3-ammoniopropyl)butane-1,4-diaminium