Compound
formate
A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects.
Definition from ChEBI (CHEBI:15740), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- CHO2
- Mass
- 45.017 g/mol
- Charge
- -1
- InChIKey
- BDAGIHXWWSANSR-UHFFFAOYSA-M
- SMILES
- [H]C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- GCH1ProteinUNIPROT:P30793substrate ofInferred only20 paths20 endpoints
- MTHFD1ProteinUNIPROT:P11586substrate ofInferred only19 paths19 endpoints
- ADI1ProteinUNIPROT:Q9BV57substrate ofInferred only10 paths5 endpoints
- AFMIDProteinUNIPROT:Q63HM1substrate ofInferred only8 paths8 endpoints
- ESDProteinUNIPROT:P10768substrate ofInferred only8 paths8 endpoints
- MTHFD1LProteinUNIPROT:Q6UB35substrate ofInferred only7 paths7 endpoints
- ALDH9A1ProteinUNIPROT:P49189metabolized byInferred only7 paths7 endpoints
- SLC26A6ProteinUNIPROT:Q9BXS9transported byInferred only6 paths6 endpoints
- SLC26A4ProteinUNIPROT:O43511transported byInferred only4 paths4 endpoints
What the reference databases state
Statements
27 statements
27 statements · 1 reference database · Subject: formate · Sources: Rhea
- formate is converted to dATPCompoundRhea RHEA:51616Inferred only
- dATP is converted to formateCompoundRhea RHEA:51616Inferred only
- dCTP is converted to formateCompoundRhea RHEA:51620Inferred only
- formate is converted to dCTPCompoundRhea RHEA:51620Inferred only
- formate is converted to dGTPCompoundRhea RHEA:51624Inferred only
- dGTP is converted to formateCompoundRhea RHEA:51624Inferred only
- formate is converted to dUTPCompoundRhea RHEA:51628Inferred only
- dUTP is converted to formateCompoundRhea RHEA:51628Inferred only
- formate is converted to formaldehydeCompoundRhea RHEA:16425Inferred only
- formaldehyde is converted to formateCompoundRhea RHEA:16425Inferred only
- hydrogen cyanide is converted to formateCompoundRhea RHEA:86867Inferred only
- formate is converted to hydrogen cyanideCompoundRhea RHEA:86867Inferred only
Show the remaining 15
- oxalate is converted to formateCompoundRhea RHEA:16509Inferred only
- formate is converted to oxalateCompoundRhea RHEA:16509Inferred only
- pyruvate is converted to formateCompoundRhea RHEA:11844Inferred only
- formate is converted to pyruvateCompoundRhea RHEA:11844Inferred only
- formate is metabolised by ALDH9A1ProteinRhea RHEA:16425Inferred only
- formate is a substrate of ADI1ProteinRhea RHEA:24504Inferred only
- formate is a substrate of ADI1ProteinRhea RHEA:14161Inferred only
- formate is a substrate of AFMIDProteinRhea RHEA:13009Inferred only
- formate is a substrate of ESDProteinRhea RHEA:14961Inferred only
- formate is a substrate of GCH1ProteinRhea RHEA:17473Inferred only
- formate is a substrate of MTHFD1ProteinRhea RHEA:20221Inferred only
- formate is a substrate of MTHFD1LProteinRhea RHEA:20221Inferred only
- formate is a substrate of PDFProteinRhea RHEA:24420Inferred only
- formate is transported by SLC26A4ProteinRhea RHEA:72267Inferred only
- formate is transported by SLC26A6ProteinRhea RHEA:72271Inferred only
Reactions
100 reactions
formate+acetyl-CoApyruvate+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:11844CC BY 4.0Reference data
formate+NADP(3-)carbon dioxide+NADPH(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:12000CC BY 4.0Reference data
CHEBI:41117+waterbenzylamine+formate
Reaction pageDirection not assertedBalanced
Rhea RHEA:12096CC BY 4.0Reference data
CHEBI:17684+waterformate+L-glutamate(1-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:12476CC BY 4.0Reference data
CHEBI:17269+AH2+2dioxygenCHEBI:18015+CHEBI:30212+formate+A+carbon dioxide+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:12677CC BY 4.0Reference data
N-formyl-L-kynurenine+waterL-kynurenine+formate+hydron
Catalysed by AFMID
Reaction pageDirection not assertedBalanced
Rhea RHEA:13009CC BY 4.0Reference data
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one+dioxygen3-(methylsulfanyl)propanoate+CO+formate+2hydron
Catalysed by ADI1
Reaction pageDirection not assertedBalanced
Rhea RHEA:14161CC BY 4.0Reference data
CHEBI:71198+waterCHEBI:11641+formate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:14549CC BY 4.0Reference data
CHEBI:17791+3reduced [NADPH--hemoprotein reductase]+3dioxygenCHEBI:30109+formate+3oxidized [NADPH--hemoprotein reductase]+4water+4hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:14917CC BY 4.0Reference data
S-formylglutathione+waterformate+glutathione+hydron
Catalysed by ESD
Reaction pageDirection not assertedBalanced
Rhea RHEA:14961CC BY 4.0Reference data
2Fe(III)-[cytochrome c553]+formate2Fe(II)-[cytochrome c553]+carbon dioxide+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15189CC BY 4.0Reference data
formate+NAD(1-)carbon dioxide+NADH(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:15985CC BY 4.0Reference data
Where it reaches
4 systems, 4 regions, 10 tissues, 10 transporter routes — routes, not measurements: transporters known to carry formate are expressed there, and no source reports it arriving.
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Other names
8 names
Resolves to: formate
- Also called
- aminateformiateformic acid, ion(1-)formic acid, ion(1−)formylateHCO2 anionhydrogen carboxylatemethanoate