Compound
CHEBI:16857
An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
What it touches on the way
Mechanistic reach
19 entities
19 entities reached.
0 reported hops19 assembled from the scaffold
- SLC1A5ProteinUNIPROT:Q15758transported byInferred only450 paths44 endpoints
- SLC38A2ProteinUNIPROT:Q96QD8transported byInferred only200 paths200 endpoints
- SLC1A4ProteinUNIPROT:P43007transported byInferred only191 paths32 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only126 paths8 endpoints
- SLC7A9ProteinUNIPROT:P82251transported byInferred only45 paths9 endpoints
- SLC7A6ProteinUNIPROT:Q92536transported byInferred only38 paths2 endpoints
- SLC38A1ProteinUNIPROT:Q9H2H9transported byInferred only38 paths38 endpoints
- SLC3A2ProteinUNIPROT:P08195transported byInferred only36 paths12 endpoints
- SLC43A1ProteinUNIPROT:O75387transported byInferred only33 paths33 endpoints
- SLC7A8ProteinUNIPROT:Q9UHI5transported byInferred only18 paths18 endpoints
- SLC7A7ProteinUNIPROT:Q9UM01transported byInferred only16 paths16 endpoints
- TARS1ProteinUNIPROT:P26639substrate ofInferred only15 paths15 endpoints
Show the remaining 7
- SDSProteinUNIPROT:P20132substrate ofInferred only7 paths7 endpoints
- SLC3A1ProteinUNIPROT:Q07837transported byInferred only5 paths1 endpoint
- SDSLProteinUNIPROT:Q96GA7substrate ofInferred only5 paths5 endpoints
- SLC36A1ProteinUNIPROT:Q7Z2H8transported byInferred only2 paths2 endpoints
- SLC38A4ProteinUNIPROT:Q969I6transported byInferred only2 paths2 endpoints
- SLC6A14ProteinUNIPROT:Q9UN76transported byInferred only2 paths2 endpoints
- SLC6A15ProteinUNIPROT:Q9H2J7transported byInferred only1 path1 endpoint
What the reference databases state
Statements
81 statements
81 statements · 1 reference database · Subject: CHEBI:16857 · Sources: Human-GEM
- CHEBI:16857 is converted to 2-oxobutanoateCompoundHuman-GEM MAR04348Inferred only
- CHEBI:16857 is a substrate of SDSProteinHuman-GEM MAR04348Inferred only
- CHEBI:16857 is a substrate of SDSLProteinHuman-GEM MAR04348Inferred only
- CHEBI:16857 is a substrate of TARS1ProteinHuman-GEM MAR05148Inferred only
- CHEBI:16857 is transported by SLC1A4ProteinHuman-GEM MAR05790Inferred only
- CHEBI:16857 is transported by SLC1A4ProteinHuman-GEM MAR05719Inferred only
- CHEBI:16857 is transported by SLC1A4ProteinHuman-GEM MAR05644Inferred only
- CHEBI:16857 is transported by SLC1A4ProteinHuman-GEM MAR05614Inferred only
- CHEBI:16857 is transported by SLC1A4ProteinHuman-GEM MAR05785Inferred only
- CHEBI:16857 is transported by SLC1A4ProteinHuman-GEM MAR05783Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05783Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05614Inferred only
Show the remaining 69
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05629Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05644Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05719Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05790Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05764Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05785Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05784Inferred only
- CHEBI:16857 is transported by SLC1A5ProteinHuman-GEM MAR05793Inferred only
- CHEBI:16857 is transported by SLC36A1ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC38A1ProteinHuman-GEM MAR05326Inferred only
- CHEBI:16857 is transported by SLC38A2ProteinHuman-GEM MAR05326Inferred only
- CHEBI:16857 is transported by SLC38A4ProteinHuman-GEM MAR05326Inferred only
- CHEBI:16857 is transported by SLC3A1ProteinHuman-GEM MAR05968Inferred only
- CHEBI:16857 is transported by SLC3A1ProteinHuman-GEM MAR05952Inferred only
- CHEBI:16857 is transported by SLC3A1ProteinHuman-GEM MAR05936Inferred only
- CHEBI:16857 is transported by SLC3A1ProteinHuman-GEM MAR05920Inferred only
- CHEBI:16857 is transported by SLC3A1ProteinHuman-GEM MAR05984Inferred only
- CHEBI:16857 is transported by SLC3A2ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC3A2ProteinHuman-GEM MAR05470Inferred only
- CHEBI:16857 is transported by SLC3A2ProteinHuman-GEM MAR05497Inferred only
- CHEBI:16857 is transported by SLC43A1ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC6A14ProteinHuman-GEM MAR07593Inferred only
- CHEBI:16857 is transported by SLC6A15ProteinHuman-GEM MAR05326Inferred only
- CHEBI:16857 is transported by SLC7A10ProteinHuman-GEM MAR05497Inferred only
- CHEBI:16857 is transported by SLC7A10ProteinHuman-GEM MAR05470Inferred only
- CHEBI:16857 is transported by SLC7A10ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC7A3ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05554Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05470Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05484Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05497Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05509Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05520Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05530Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05539Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05547Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05560Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05569Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05572Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05576Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05659Inferred only
- CHEBI:16857 is transported by SLC7A5ProteinHuman-GEM MAR05674Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05968Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05784Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05782Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05788Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05764Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05629Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05791Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05614Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05796Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05892Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05893Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05894Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05895Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05896Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05785Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05920Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05936Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05952Inferred only
- CHEBI:16857 is transported by SLC7A6ProteinHuman-GEM MAR05984Inferred only
- CHEBI:16857 is transported by SLC7A7ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC7A8ProteinHuman-GEM MAR05091Inferred only
- CHEBI:16857 is transported by SLC7A9ProteinHuman-GEM MAR05920Inferred only
- CHEBI:16857 is transported by SLC7A9ProteinHuman-GEM MAR05968Inferred only
- CHEBI:16857 is transported by SLC7A9ProteinHuman-GEM MAR05984Inferred only
- CHEBI:16857 is transported by SLC7A9ProteinHuman-GEM MAR05936Inferred only
- CHEBI:16857 is transported by SLC7A9ProteinHuman-GEM MAR05952Inferred only
Reactions
132 reactions
L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
CHEBI:16857acetaldehyde+glycine
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR04284CC BY 4.0Reference data
CHEBI:168572-oxobutanoate+proton+ammonium
Reaction pageLeft to rightBalancedEC 4.3.1.19cytosol
Human-GEM MAR04348CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR05066CC BY 4.0Reference data
Transported by SLC3A2 & SLC7A8 or SLC7A5 or SLC36A1 or SLC7A10 or SLC43A1 or SLC7A7 or SLC7A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05091CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05117CC BY 4.0Reference data
ATP+CHEBI:16857+MAM03079cAMP+MAM02419c+diphosphate(3-)
Catalysed by TARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.3cytosol
Human-GEM MAR05148CC BY 4.0Reference data
MAM01308c+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by ALB
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05258CC BY 4.0Reference data
MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971+9L-isoleucine+64L-leucine+60CHEBI:18019+7L-methionine+35L-phenylalanine+608phosphate(3-)+24CHEBI:17203+28L-seryl residue+29CHEBI:16857+2L-tryptophan+19CHEBI:17895+43L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05259CC BY 4.0Reference data
MAM01343c+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR05260CC BY 4.0Reference data
MAM01343l+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine
Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives
Reaction pageLeft to rightBalancedlysosome
Human-GEM MAR05261CC BY 4.0Reference data
Where it reaches
10 systems, 28 regions, 221 tissues, 393 transporter routes — routes, not measurements: transporters known to carry CHEBI:16857 are expressed there, and no source reports it arriving.
Loading the model…
Other names
12 names
Resolves to: CHEBI:16857
- Also called
- (2S,3R)-(-)-Threonine(2S,3R)-2-amino-3-hydroxybutanoic acid(2S)-threonine2-Amino-3-hydroxybutyric acidL-(-)-ThreonineL-2-Amino-3-hydroxybutyric acidL-alpha-amino-beta-hydroxybutyric acidL-ThreoninL-α-amino-β-hydroxybutyric acidThrTHREONINE
- Systematic name
- L-threonine