Compound
estrone 3-sulfate
The conjugate base of estrone 3-sulfate; major species at pH 7.3.
Definition from ChEBI (CHEBI:60050), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C18H21O5S
- Mass
- 349.428 g/mol
- Charge
- -1
- InChIKey
- JKKFKPJIXZFSSB-CBZIJGRNSA-M
- SMILES
- [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(OS(=O)(=O)[O-])cc3CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
20 entities
20 entities reached.
0 reported hops20 assembled from the scaffold
- ABCA8ProteinUNIPROT:O94911transported byInferred only98 paths48 endpoints
- STSProteinUNIPROT:P08842substrate ofInferred only42 paths14 endpoints
- SLC47A1ProteinUNIPROT:Q96FL8transported byInferred only17 paths16 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only15 paths2 endpoints
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- SLCO4A1ProteinUNIPROT:Q96BD0transported byInferred only12 paths4 endpoints
- SLC10A6ProteinUNIPROT:Q3KNW5transported byInferred only11 paths11 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only9 paths9 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only9 paths2 endpoints
- SLCO2B1ProteinUNIPROT:O94956transported byInferred only8 paths2 endpoints
- SLCO3A1ProteinUNIPROT:Q9UIG8transported byInferred only6 paths3 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only5 paths5 endpoints
Show the remaining 8
- SLC10A1ProteinUNIPROT:Q14973transported byInferred only4 paths2 endpoints
- SLC22A11ProteinUNIPROT:Q9NSA0transported byInferred only4 paths2 endpoints
- SLCO1C1ProteinUNIPROT:Q9NYB5transported byInferred only4 paths2 endpoints
- SLC22A7ProteinUNIPROT:Q9Y694transported byInferred only4 paths2 endpoints
- SLC10A2ProteinUNIPROT:Q12908transported byInferred only2 paths2 endpoints
- SLC22A8ProteinUNIPROT:Q8TCC7transported byInferred only2 paths1 endpoint
- SLC46A3ProteinUNIPROT:Q7Z3Q1transported byInferred only1 path1 endpoint
- SLC47A2ProteinUNIPROT:Q86VL8transported byInferred only1 path1 endpoint
What the reference databases state
Statements
51 statements
51 statements · 2 reference databases · Subject: estrone 3-sulfate · Sources: Human-GEM, Rhea
- estrone is converted to estrone 3-sulfateCompoundRhea RHEA:15973Inferred only
- estrone is converted to estrone 3-sulfateCompoundHuman-GEM MAR02037Inferred only
- estrone 3-sulfate is a substrate of STSProteinHuman-GEM MAR07945Inferred only
- estrone 3-sulfate is a substrate of STSProteinHuman-GEM MAR02038Inferred only
- estrone 3-sulfate is a substrate of STSProteinRhea RHEA:31055Inferred only
- estrone 3-sulfate is transported by ABCA8ProteinRhea RHEA:65956Inferred only
- estrone 3-sulfate is transported by ABCA8ProteinHuman-GEM MAR09881Inferred only
- estrone 3-sulfate is transported by ABCC11ProteinHuman-GEM MAR09880Inferred only
- estrone 3-sulfate is transported by ABCC11ProteinRhea RHEA:61348Inferred only
- estrone 3-sulfate is transported by ABCG2ProteinRhea RHEA:61348Inferred only
- estrone 3-sulfate is transported by SLC10A1ProteinHuman-GEM MAR07946Inferred only
- estrone 3-sulfate is transported by SLC10A1ProteinRhea RHEA:71083Inferred only
Show the remaining 39
- estrone 3-sulfate is transported by SLC10A2ProteinHuman-GEM MAR07946Inferred only
- estrone 3-sulfate is transported by SLC10A6ProteinRhea RHEA:71083Inferred only
- estrone 3-sulfate is transported by SLC22A11ProteinHuman-GEM MAR09624Inferred only
- estrone 3-sulfate is transported by SLC22A11ProteinRhea RHEA:72151Inferred only
- estrone 3-sulfate is transported by SLC22A24ProteinRhea RHEA:72151Inferred only
- estrone 3-sulfate is transported by SLC22A7ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLC22A7ProteinHuman-GEM MAR09624Inferred only
- estrone 3-sulfate is transported by SLC22A8ProteinRhea RHEA:72399Inferred only
- estrone 3-sulfate is transported by SLC22A8ProteinRhea RHEA:72151Inferred only
- estrone 3-sulfate is transported by SLC22A9ProteinRhea RHEA:72051Inferred only
- estrone 3-sulfate is transported by SLC22A9ProteinRhea RHEA:72559Inferred only
- estrone 3-sulfate is transported by SLC22A9ProteinRhea RHEA:72555Inferred only
- estrone 3-sulfate is transported by SLC46A3ProteinRhea RHEA:75483Inferred only
- estrone 3-sulfate is transported by SLC47A1ProteinRhea RHEA:72139Inferred only
- estrone 3-sulfate is transported by SLC47A2ProteinRhea RHEA:72139Inferred only
- estrone 3-sulfate is transported by SLC51AProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLC51BProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO1A2ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO1A2ProteinHuman-GEM MAR06129Inferred only
- estrone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR06129Inferred only
- estrone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR06132Inferred only
- estrone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR06131Inferred only
- estrone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR06130Inferred only
- estrone 3-sulfate is transported by SLCO1B1ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO1B3ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO1B3ProteinHuman-GEM MAR06129Inferred only
- estrone 3-sulfate is transported by SLCO1B3ProteinRhea RHEA:73055Inferred only
- estrone 3-sulfate is transported by SLCO1C1ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO1C1ProteinHuman-GEM MAR06129Inferred only
- estrone 3-sulfate is transported by SLCO2B1ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO2B1ProteinHuman-GEM MAR06129Inferred only
- estrone 3-sulfate is transported by SLCO2B1ProteinHuman-GEM MAR06248Inferred only
- estrone 3-sulfate is transported by SLCO2B1ProteinRhea RHEA:73055Inferred only
- estrone 3-sulfate is transported by SLCO3A1ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO3A1ProteinHuman-GEM MAR06129Inferred only
- estrone 3-sulfate is transported by SLCO4A1ProteinRhea RHEA:71835Inferred only
- estrone 3-sulfate is transported by SLCO4A1ProteinRhea RHEA:72239Inferred only
- estrone 3-sulfate is transported by SLCO4A1ProteinHuman-GEM MAR06129Inferred only
- estrone 3-sulfate is transported by SLCO4C1ProteinRhea RHEA:71835Inferred only
Reactions
31 reactions
estrone+3'-phospho-5'-adenylyl sulfateestrone 3-sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1E1 or SULT1A1 or SULT1A3
Reaction pageLeft to rightBalancedEC 2.8.2.4cytosol
Human-GEM MAR02037CC BY 4.0Reference data
estrone 3-sulfate+waterestrone+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.1, 3.1.6.2cytosol
Human-GEM MAR02038CC BY 4.0Reference data
estrone 3-sulfate+hydrogencarbonateestrone 3-sulfate+hydrogencarbonate
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO2B1 or SLCO1C1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06129CC BY 4.0Reference data
estrone 3-sulfate+MAM01980c+hydrogencarbonateestrone 3-sulfate+MAM01980e+hydrogencarbonate
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminableextracellular space, cytosol
Human-GEM MAR06130CC BY 4.0Reference data
estrone 3-sulfate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathioneestrone 3-sulfate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06131CC BY 4.0Reference data
estrone 3-sulfate+hydrogencarbonate+MAM02901cestrone 3-sulfate+hydrogencarbonate+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06132CC BY 4.0Reference data
estrone 3-sulfateestrone 3-sulfate
Transported by SLCO2B1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06248CC BY 4.0Reference data
estrone 3-sulfateestrone 3-sulfate
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07944CC BY 4.0Reference data
estrone 3-sulfate+waterestrone+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2endoplasmic reticulum
Human-GEM MAR07945CC BY 4.0Reference data
estrone 3-sulfate+2sodium(1+)estrone 3-sulfate+2sodium(1+)
Transported by SLC10A1 or SLC10A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07946CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09317CC BY 4.0Reference data
2-oxoglutarate(2-)+estrone 3-sulfate2-oxoglutarate(2-)+estrone 3-sulfate
Transported by SLC22A7 or SLC22A11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09624CC BY 4.0Reference data
Where it reaches
10 systems, 23 regions, 83 tissues, 125 transporter routes — routes, not measurements: transporters known to carry estrone 3-sulfate are expressed there, and no source reports it arriving.
Loading the model…
Other names
2 names
Resolves to: estrone 3-sulfate
- Also called
- estrone 3-sulfate anion
- Systematic name
- 17-oxoestra-1,3,5(10)-trien-3-yl sulfate